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Database: UniProt
Entry: H6C354_EXODN
LinkDB: H6C354_EXODN
Original site: H6C354_EXODN 
ID   H6C354_EXODN            Unreviewed;       859 AA.
AC   H6C354;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   07-JUN-2017, entry version 17.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=HMPREF1120_06087 {ECO:0000313|EMBL:EHY58069.1};
OS   Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656)
OS   (Black yeast) (Wangiella dermatitidis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae;
OC   Exophiala.
OX   NCBI_TaxID=858893 {ECO:0000313|EMBL:EHY58069.1, ECO:0000313|Proteomes:UP000007304};
RN   [1] {ECO:0000313|Proteomes:UP000007304}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 34100 / CBS 525.76 / NIH/UT8656
RC   {ECO:0000313|Proteomes:UP000007304};
RX   PubMed=24496724; DOI=10.1534/g3.113.009241;
RA   Chen Z., Martinez D.A., Gujja S., Sykes S.M., Zeng Q., Szaniszlo P.J.,
RA   Wang Z., Cuomo C.A.;
RT   "Comparative genomic and transcriptomic analysis of Wangiella
RT   dermatitidis, a major cause of phaeohyphomycosis and a model black
RT   yeast human pathogen.";
RL   G3 (Bethesda) 0:0-0(2014).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; JH226134; EHY58069.1; -; Genomic_DNA.
DR   RefSeq; XP_009158530.1; XM_009160282.1.
DR   EnsemblFungi; EHY58069; EHY58069; HMPREF1120_06087.
DR   GeneID; 20310726; -.
DR   InParanoid; H6C354; -.
DR   OrthoDB; EOG092C0YCY; -.
DR   Proteomes; UP000007304; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007304};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007304};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    426    451       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    463    488       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    548    566       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    578    603       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    642    662       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    761    780       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    792    815       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      101    128       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   859 AA;  97747 MW;  B93FE82D0A4803CB CRC64;
     MAHKDTLFRS ADMSLTQLYI SNEIGREVVS ALGELGVVQF RDLNADTNAF QRTFTKEIRR
     LDNVERQLRY FKSQMEKSNI EMRSHWDFAE DMLAAPQASE IDELADRAET LEHRISSLNE
     SYETLKKREV ELTEWRWVLK EAGGFFDRAH GQTDDIRASV DEDDAPLLRN TEAEEGRANG
     SVGQQQSFAV MNIGFVAGVI PRERLAAFER ILWRTLRGNL YMNQSEIPEP IVNPETNEEV
     RKNVFVIFAH GKEIIAKIRK ISESLGADLY NVDENSDVRR DQIHEVNTRL SDLASVLRNT
     KTTLDAELNA IARSLAAWLI VIKKEKAVYN ALNMCSYDQA RKTLIAEAWC PTNSLPQIRA
     TLQDVNDRAG LSVPTIVNQI KTNKTPPTYN KTNKFTEGFQ TIIDAYGTAK YQEVNPGLYT
     IVTFPFLFAV MFGDFGHGSL MTMAAAAMIY WEKPLQRSKQ DELFAMAFYG RYIMLMMGIF
     SMYTGLIYND VFSKGFTPFP SAWEFPEEGR PEVTAHLKGG YRYPFGIDWA WHGSENDLLF
     SNSLKMKLSI LMGWAHMTYA LCFSYINARH FKTPIDIWGN FVPGMVFFQS IFGYLSFCIV
     YKWSIDWQAI GRNPPSLLNM LIQMFLSPGN VEEGEQLYSG QAGVQVVLVL IAVINVPILL
     LLKPLYLRWQ HQKTAAQGYR GIGDTSRVAH ATDLDDDENN NSRRMNGRPS EEEEEEGAMI
     TENIGADEEH EEFEFSEVMI HQTIHTIEFC LNCVSHTASY LRLWALSLAH QQLSVVLWNM
     TLGNAFGMTG GLQVVMIIVT FAFWFVLTIA VLCVMEGTSA MLHSLRLHWV EAMSKHFVGE
     GVPFEPFSFK LLLEEDPVD
//
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