ID H6C3P1_EXODN Unreviewed; 413 AA.
AC H6C3P1;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase {ECO:0000313|EMBL:EHY58256.1};
GN ORFNames=HMPREF1120_06268 {ECO:0000313|EMBL:EHY58256.1};
OS Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black
OS yeast) (Wangiella dermatitidis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=858893 {ECO:0000313|EMBL:EHY58256.1, ECO:0000313|Proteomes:UP000007304};
RN [1] {ECO:0000313|EMBL:EHY58256.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NIH/UT8656 {ECO:0000313|EMBL:EHY58256.1};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Wang Z., Hunicke-Smith S., Szanislo P.J., Earl A., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Exophiala (Wangiella) dermatitidis NIH/UT8656.";
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; JH226134; EHY58256.1; -; Genomic_DNA.
DR RefSeq; XP_009158717.1; XM_009160469.1.
DR AlphaFoldDB; H6C3P1; -.
DR STRING; 858893.H6C3P1; -.
DR GeneID; 20310907; -.
DR VEuPathDB; FungiDB:HMPREF1120_06268; -.
DR eggNOG; ENOG502SKSR; Eukaryota.
DR HOGENOM; CLU_058877_0_0_1; -.
DR InParanoid; H6C3P1; -.
DR OMA; YNRTRFW; -.
DR OrthoDB; 5488137at2759; -.
DR Proteomes; UP000007304; Unassembled WGS sequence.
DR GO; GO:0003871; F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0009086; P:methionine biosynthetic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd03311; CIMS_C_terminal_like; 1.
DR Gene3D; 3.20.20.210; -; 1.
DR InterPro; IPR002629; Met_Synth_C/arc.
DR InterPro; IPR038071; UROD/MetE-like_sf.
DR PANTHER; PTHR43844; METHIONINE SYNTHASE; 1.
DR PANTHER; PTHR43844:SF2; SYNTHASE, VITAMIN-B12 INDEPENDENT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12060)-RELATED; 1.
DR Pfam; PF01717; Meth_synt_2; 1.
DR SUPFAM; SSF51726; UROD/MetE-like; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:EHY58256.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007304};
KW Transferase {ECO:0000313|EMBL:EHY58256.1}.
FT DOMAIN 191..385
FT /note="Cobalamin-independent methionine synthase MetE C-
FT terminal/archaeal"
FT /evidence="ECO:0000259|Pfam:PF01717"
SQ SEQUENCE 413 AA; 46767 MW; C02B1F6D61D52BA6 CRC64;
MATTTSTTTV QPPFRAEQMG SLLRPQKLLD VRSAIRDNPN LTPEEAGLPA VEKEAVAQIV
KTQRDLGFKG VTSGEYNRTR FWGLFWDELE GTVRLQDADA SMFRLYHPDV VSLIEQDRKV
MPGDSVIAGS KIRHPGPEKV KSNLHELKLV QEATPREEWG NIKLTMITPA WFHMRYKQGR
AYTPEAYSND ADYFKDVAKA YQDELKILYD AGLRNVQFDD PGLAYFCSND FRNGWAQDKD
NIGTVDDLLD AYIQLYNDSI SQCPPDMHTG VHLCRGNFIG GRHFAEGAYD IIAKKLFENL
NVNTFYLEYD TERAGGFEPL KYLPKNKNVI VGCISTKVRD LEDKEEMKKR IYKAADFVAE
GSNQTREEAL KRIGISPQCG FSTHESGYPL SDQDQSAKLA LVREIADEIW GEP
//
