ID H6C6L4_EXODN Unreviewed; 737 AA.
AC H6C6L4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE RecName: Full=Peptidase A1 domain-containing protein {ECO:0000259|PROSITE:PS51767};
GN ORFNames=HMPREF1120_07351 {ECO:0000313|EMBL:EHY59360.1};
OS Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black
OS yeast) (Wangiella dermatitidis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=858893 {ECO:0000313|EMBL:EHY59360.1, ECO:0000313|Proteomes:UP000007304};
RN [1] {ECO:0000313|EMBL:EHY59360.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NIH/UT8656 {ECO:0000313|EMBL:EHY59360.1};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Wang Z., Hunicke-Smith S., Szanislo P.J., Earl A., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Exophiala (Wangiella) dermatitidis NIH/UT8656.";
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447}.
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DR EMBL; JH226135; EHY59360.1; -; Genomic_DNA.
DR RefSeq; XP_009159821.1; XM_009161573.1.
DR AlphaFoldDB; H6C6L4; -.
DR STRING; 858893.H6C6L4; -.
DR GeneID; 20311990; -.
DR VEuPathDB; FungiDB:HMPREF1120_07351; -.
DR eggNOG; KOG1339; Eukaryota.
DR HOGENOM; CLU_009988_1_0_1; -.
DR InParanoid; H6C6L4; -.
DR OMA; WIPSYSY; -.
DR OrthoDB; 1831139at2759; -.
DR Proteomes; UP000007304; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd05471; pepsin_like; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR034164; Pepsin-like_dom.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF51; NAPSIN-A; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007304};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 458..480
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 57..411
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT REGION 539..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 552..569
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 570..590
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 605..636
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..660
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 673..687
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 715..737
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 737 AA; 78938 MW; 84D3E2CAB3F3F5A1 CRC64;
MRLLDGVYPS LVLRLFNCHL LIAITHVLRP CFAAYASSEP FVATTSTDFF GYDGSWSAVT
IRVGTPEQWL YVLPSTLSQE TWVIGPAGCD GTTTCESKRG GLFFANESST FQPIGFYDLN
FDSQLGNAGY GNYGLDTLCL DDTTSVSDQI IAVVNSTEQW IGSLGLGVQE TRFNGTSNYL
PLLSSLAQDR ILIPSHSYGY TAGASYRLKS VPASLIFGGV DTNRFTPNSF TFSLSSDYAP
VVAITSIDVY SGGIDIPDAW DSNPQTLLNS SQAALFTIDS STPFLWLPET VCDAFESALN
LTYDDDLQLY VFPNDSTSSP EALAALNLTF SFTLAELPNS PEGITFKLPY DAFNLQLSYP
FPNLDANFTS PATNYFPLRR AANSSQYTIG RAFLQETYLT VDYERNNFSV SQAVFTSDAV
SHVNLSAIVA PDNSKWPVPE SGGESGGQYG GLSTGAKAGI GVGVAGGVLT IAVLLWLFCF
RRKNAKEAVS TEKPKRRGIL ARLNRSLGSK TSVSELLGDK RHPTEVPADS SVTRFELSGD
TPAEMPAAPV SPSFFASTQT GSRGSRNSTR QPAELEHRDS TTKGDDLAVS ERSRSPAPPY
SPAAANNHPF SNGISPYSAS NSHGLGTHSS GEQGISPVGA GSGGHSMGSS NSNNRSLPSP
VSPDDMHRTR GPSLRDSQTS PSRTDSLLVP RLNGRPPSRS PSTGSRFREE GLGGSGEEQT
TTPPRTGQQG ARFSWEQ
//