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Database: UniProt
Entry: H6C741_EXODN
LinkDB: H6C741_EXODN
Original site: H6C741_EXODN 
ID   H6C741_EXODN            Unreviewed;       995 AA.
AC   H6C741;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   24-JAN-2024, entry version 51.
DE   SubName: Full=Lysine-specific histone demethylase 1 {ECO:0000313|EMBL:EHY59537.1};
GN   ORFNames=HMPREF1120_07525 {ECO:0000313|EMBL:EHY59537.1};
OS   Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black
OS   yeast) (Wangiella dermatitidis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX   NCBI_TaxID=858893 {ECO:0000313|EMBL:EHY59537.1, ECO:0000313|Proteomes:UP000007304};
RN   [1] {ECO:0000313|EMBL:EHY59537.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NIH/UT8656 {ECO:0000313|EMBL:EHY59537.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Cuomo C., Wang Z., Hunicke-Smith S., Szanislo P.J., Earl A., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA   Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA   Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A.,
RA   Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Exophiala (Wangiella) dermatitidis NIH/UT8656.";
RL   Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; JH226135; EHY59537.1; -; Genomic_DNA.
DR   RefSeq; XP_009159998.1; XM_009161750.1.
DR   AlphaFoldDB; H6C741; -.
DR   STRING; 858893.H6C741; -.
DR   GeneID; 20312164; -.
DR   VEuPathDB; FungiDB:HMPREF1120_07525; -.
DR   eggNOG; KOG0029; Eukaryota.
DR   HOGENOM; CLU_004498_1_2_1; -.
DR   InParanoid; H6C741; -.
DR   OMA; WCAENPF; -.
DR   OrthoDB; 5402444at2759; -.
DR   Proteomes; UP000007304; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0010468; P:regulation of gene expression; IEA:UniProt.
DR   Gene3D; 3.90.660.10; -; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR   Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR002937; Amino_oxidase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR007526; SWIRM.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR10742; FLAVIN MONOAMINE OXIDASE; 1.
DR   PANTHER; PTHR10742:SF386; LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A; 1.
DR   Pfam; PF01593; Amino_oxidase; 1.
DR   Pfam; PF09011; HMG_box_2; 1.
DR   Pfam; PF04433; SWIRM; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   SUPFAM; SSF47095; HMG-box; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
DR   PROSITE; PS50934; SWIRM; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW   Methyltransferase {ECO:0000313|EMBL:EHY59537.1};
KW   Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007304};
KW   Transferase {ECO:0000313|EMBL:EHY59537.1}.
FT   DOMAIN          97..192
FT                   /note="SWIRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50934"
FT   DOMAIN          867..946
FT                   /note="HMG box"
FT                   /evidence="ECO:0000259|PROSITE:PS50118"
FT   DNA_BIND        867..946
FT                   /note="HMG box"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT   REGION          1..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          388..413
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..51
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   995 AA;  111266 MW;  3D2FC7678B92FC7D CRC64;
     MEEDDDEDYS SSSGPASILR NLQHESENRD SPNSSLTSVS TASSVTEQKV KVTVKQEVKP
     ETPEKAIPYM FLKAPATCRA KSSIPSRLSP SEYANQCVAA AEASRLNPYA LHEDEHKLLQ
     DKLCYSHVTV YLNIRNGILR LWTRNPSVSV TLEEAIGCAR DERWTRLACF AYEWLLRRGY
     INFGCVEPAA IPKATGRGRK KEPQRETIVV IGGGVAGLST ARQLTNLFHH YPDRAAPRII
     VLEGRDRIGG RIYSHPLTSM RTSKLAPGQR PTAEMGAHII VGFERGNPLD AIVRGQLALD
     YHLLRDLSTL YDIDGTPVNG ANDAMIERLY NDILDRTGHY RLKHTVKKTA QGDKDYIDAG
     RDPPDEESIT IKQYEEATAL GTIDQLLPKK KSRRRGAGHR AAKGDKSSEE VDTNMDTKMQ
     LPAAQAAKEF GFMLRKTTQM HETLELDDLA RQLNQSLGAV MDAGVDQYQQ FLDLKPYALR
     LLNWHFANLE YANAANVDKL SLRGWDQDIG NEFEGEHAQV VGGYQQVPRA LWRHPEPLDV
     RTRKVVKSIK YSAAGSQTKA TVTCEDGQSI EADRVVFTAP LGVLKNQSIQ FDPPLPQWKR
     DAIRRMGFGL LNKVVLVFER PFWDVHRDMF GLLRGPRNGP GLQQSDYKEG RGQFYLFWNC
     IETTGLPVLI ALMAGEAAHE AEKIPDEELV GQCLGQLRNV FGPTNVPMPI ESIVTRWGSD
     RFARGTYSFV AAEARPGDYD LIAAPIQNLF FAGEATIATH PATVHGAYLS GLRAAHEVFE
     SMVGPIAIPP TLVPPATASK GCSASAELTL MDTHMAVGGK RKGDELLPAG TFTRPVKEKD
     NSLQEAWDAA MWVRIYDDLG PPPVKPAKLT VNAFLLYSGE HWDEVKNRLG GERKKTGRKS
     KHSERDQVRI ELGKMWAALS EEEKKPYTDR IQQNREENER AMKEWAAKAA EWDRRTWEVK
     DVWIKEGNSF EEFCRRKRED DALMDAAAGA KRAKL
//
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