ID H6C7E8_EXODN Unreviewed; 1131 AA.
AC H6C7E8;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=NuA3 HAT complex component NTO1 {ECO:0000313|EMBL:EHY59644.1};
GN ORFNames=HMPREF1120_07629 {ECO:0000313|EMBL:EHY59644.1};
OS Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black
OS yeast) (Wangiella dermatitidis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=858893 {ECO:0000313|EMBL:EHY59644.1, ECO:0000313|Proteomes:UP000007304};
RN [1] {ECO:0000313|EMBL:EHY59644.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NIH/UT8656 {ECO:0000313|EMBL:EHY59644.1};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Wang Z., Hunicke-Smith S., Szanislo P.J., Earl A., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Exophiala (Wangiella) dermatitidis NIH/UT8656.";
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JH226135; EHY59644.1; -; Genomic_DNA.
DR RefSeq; XP_009160105.1; XM_009161857.1.
DR AlphaFoldDB; H6C7E8; -.
DR STRING; 858893.H6C7E8; -.
DR GeneID; 20312268; -.
DR VEuPathDB; FungiDB:HMPREF1120_07629; -.
DR eggNOG; KOG0955; Eukaryota.
DR HOGENOM; CLU_002663_0_0_1; -.
DR InParanoid; H6C7E8; -.
DR OMA; NTSKWSH; -.
DR OrthoDB; 163389at2759; -.
DR Proteomes; UP000007304; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15670; ePHD_BRPF; 1.
DR CDD; cd15492; PHD_BRPF_JADE_like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR019542; Enhancer_polycomb-like_N.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13793:SF164; BROMODOMAIN-CONTAINING PROTEIN, 140KD, ISOFORM A; 1.
DR PANTHER; PTHR13793; PHD FINGER PROTEINS; 1.
DR Pfam; PF10513; EPL1; 1.
DR Pfam; PF13831; PHD_2; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007304};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 405..455
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 459..577
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT REGION 1..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 193..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 371..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 988..1028
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1093..1131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..26
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..106
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1003..1028
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1115..1131
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1131 AA; 125789 MW; A2A1B81083F6976D CRC64;
MGPLRTAQAR TRSRRDTTKS AGVFDQLDDD DLADFQDLEP PSKRIRTSRK AQAPSKWIPG
GPGGGGRHID NGSTRSATRT PRANDEYVLP QTRPRSSRER RRTMTATPRY SARSRNRGST
RPRYSTAAAA SAAVAHGDGY KPREERGWEE FHPDLDLGAD FAVIPSEEVD GLLKKPTIDG
ISQDGGMVGE GVHTTSGSAT PPKRRPGRPH RTQNSMVSAL LTPEAPRLVP VPGPNPRERL
TLPKPSYRVL DPFVSYEQKG IAQVDFVDKS MANVGYQESE IFLRPARTYI RQTEGSAEED
LDLSPDLVTT GENSAIGSTG VGRVEYDMDE QDVKWLEAFN KGRSKDGAQT IKPAIFEITM
TKIEKEWHAL EKRIPKPNPK APQTQRPRSS SAAAVNGEPA GEEPDSKCAI CDDGDCENAN
AIVFCDGCDL AVHQECYGVP YIPEGQWLCR KCQLVGNSRP SCIFCPNEGG AFKQTNNSKW
AHLFCATWIP EVSIGNPSLM EPITDVEKVP PGRWKLVCYI CKQEMGACIQ CSDGRCYEAF
HLTCARQAGL YLRMKTGGGQ NSLMDKSQLR AYCHKHTPAD WKHEHNTDRA YEEATKYFKE
HFRGQIWADS RASALAINDT HDAPNSEKGQ LKVTLTNKKG QKQKTIWRLP SGAPVIPEVI
LKSIEDSLVR FTVQKKKEFV SEICKYWTLK REARRGAALL KRLQLQMDTF SSFEVTRRDY
KAQGAAGRAR LDRRIEFAEI LAEDMSRIVQ LCELVKQREA LKLQEALLLK DIVDTVYLPI
PHLLEPIVDK ALKLDRGLFR NELVELRAKV MRKEHTSVAS FAHDVVKVIT SHFGNDASSL
PELIALVSGR AEDMSSEDRD RRTLARRIVK AIEPLIEDAT RKEAELNGRP YAQQIRELDQ
ALLSRHDSLM DSTELPVFDP VEQKHETGMA SPEDGDDVEM VDVPDTVEQV QEDGIETEIA
VKDIMEKADF SKQDGIRVKA AEVFAETPPA STNGFKPDNH MDGDATTGQT GSFEPPTPPI
SLQDHSHVSP PQGGIPWYAA PFDPDGTTIF EERWTGPEVL REMSEELSEM DEEELQGLGA
GDEVDVEDAV APALESDTLS TDAAAAKKAS RRGSKRGRAS EWGTRSFRLR R
//
