ID H6C7W8_EXODN Unreviewed; 639 AA.
AC H6C7W8;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EHY60195.1};
GN ORFNames=HMPREF1120_08165 {ECO:0000313|EMBL:EHY60195.1};
OS Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black
OS yeast) (Wangiella dermatitidis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=858893 {ECO:0000313|EMBL:EHY60195.1, ECO:0000313|Proteomes:UP000007304};
RN [1] {ECO:0000313|EMBL:EHY60195.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NIH/UT8656 {ECO:0000313|EMBL:EHY60195.1};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Wang Z., Hunicke-Smith S., Szanislo P.J., Earl A., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Exophiala (Wangiella) dermatitidis NIH/UT8656.";
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the regulatory network controlling carbon source
CC utilization through ubiquitination and deubiquitination involving creA,
CC creB, creC, creD and acrB. Required to prevent the proteolysis of the
CC CreB deubiquitinating enzyme in the absence of carbon catabolite
CC repression. CreB deubiquitinating enzyme stabilized in a complex with
CC the CreC leads to the expression of genes such as those in the proline
CC and quinate pathways. {ECO:0000256|ARBA:ARBA00037241}.
CC -!- SUBUNIT: Interacts with creB. {ECO:0000256|ARBA:ARBA00038682}.
CC -!- SIMILARITY: Belongs to the WD repeat creC family.
CC {ECO:0000256|ARBA:ARBA00038107}.
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DR EMBL; JH226136; EHY60195.1; -; Genomic_DNA.
DR RefSeq; XP_009160656.1; XM_009162408.1.
DR AlphaFoldDB; H6C7W8; -.
DR STRING; 858893.H6C7W8; -.
DR GeneID; 20312804; -.
DR VEuPathDB; FungiDB:HMPREF1120_08165; -.
DR eggNOG; KOG2394; Eukaryota.
DR HOGENOM; CLU_016971_1_1_1; -.
DR InParanoid; H6C7W8; -.
DR OMA; LHRPKAA; -.
DR OrthoDB; 1513505at2759; -.
DR Proteomes; UP000007304; Unassembled WGS sequence.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR14107:SF16; AT02583P; 1.
DR PANTHER; PTHR14107; WD REPEAT PROTEIN; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007304};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT REPEAT 429..470
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 51..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 118..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..149
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 639 AA; 70915 MW; 8F72ED10F9062D89 CRC64;
MFAIPPPPRY PTNSGLIAAT LETQNTLTHR EGPEYTFQAG EGTYVLRDDL QLATPPPHPS
EAPVLNPNPL ATGVVPPTSG VKLSLVSLNP KQVDHDLYKP PTATSSLLRW KSLGLNNNRE
SKEAKESREA REREREREQH QEKESRFSME TTSDTSNPAA SANGSNKSST VRAFGEGNAA
LSPVISRGDG LKRRKPKNNI IKSNSSFVSR VIPHEALPKK LAERDQGGTF AFANINRAFQ
WLDLSSSSKQ DPLTKILFTK AHMLCHDVNP LTKHSTHMDV VMGSSASDII WYEPMSQKYA
RINKNGIINN SAVAKIKWIP GSENHFLAAH MDGKLVVYDK EKEDAPFVSE EMVDEGIGIE
DDDEDSALVI SKSVNSSNQR ANPVALWKIS NQAITDFAFS PDSKHLAVVG DDGCLRIIDY
LQERMTDLYS SYYGAFTCVC WSPDGKYVLT GGQDDLVTIW SLEERQIIAR CPGHDSWVTA
VAFDPWRCDG QSYRFGSVGE DCKLLLWDFS VGMLHRPKGL TARTRGSIST QSVSLLRQRT
ESNSVINRIR SDSNRTGSFV QQDIVDESEF INHPVEPRAR TAQLPPVMSK KIDEHPLSGL
AFEQDCIITS CLEGHVRTWD RPREGANSSQ IDLAGNQRP
//