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Database: UniProt
Entry: H6C8F8_EXODN
LinkDB: H6C8F8_EXODN
Original site: H6C8F8_EXODN 
ID   H6C8F8_EXODN            Unreviewed;      2137 AA.
AC   H6C8F8;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-SEP-2017, entry version 33.
DE   SubName: Full=Calcium channel, voltage-dependent, N type, alpha 1B subunit {ECO:0000313|EMBL:EHY60385.1};
GN   ORFNames=HMPREF1120_08350 {ECO:0000313|EMBL:EHY60385.1};
OS   Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656)
OS   (Black yeast) (Wangiella dermatitidis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae;
OC   Exophiala.
OX   NCBI_TaxID=858893 {ECO:0000313|EMBL:EHY60385.1, ECO:0000313|Proteomes:UP000007304};
RN   [1] {ECO:0000313|Proteomes:UP000007304}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 34100 / CBS 525.76 / NIH/UT8656
RC   {ECO:0000313|Proteomes:UP000007304};
RX   PubMed=24496724; DOI=10.1534/g3.113.009241;
RA   Chen Z., Martinez D.A., Gujja S., Sykes S.M., Zeng Q., Szaniszlo P.J.,
RA   Wang Z., Cuomo C.A.;
RT   "Comparative genomic and transcriptomic analysis of Wangiella
RT   dermatitidis, a major cause of phaeohyphomycosis and a model black
RT   yeast human pathogen.";
RL   G3 (Bethesda) 0:0-0(2014).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; JH226136; EHY60385.1; -; Genomic_DNA.
DR   RefSeq; XP_009160846.1; XM_009162598.1.
DR   EnsemblFungi; EHY60385; EHY60385; HMPREF1120_08350.
DR   GeneID; 20312989; -.
DR   InParanoid; H6C8F8; -.
DR   OrthoDB; EOG092C00XX; -.
DR   Proteomes; UP000007304; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007304};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007304};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    364    381       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    401    420       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    509    528       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    534    559       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    566    588       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    705    731       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    775    792       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    804    826       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    890    915       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    968    992       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1199   1226       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1246   1267       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1279   1297       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1328   1356       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1413   1432       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1452   1474       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1536   1553       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1565   1583       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1595   1615       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1656   1677       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1753   1772       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1791   1826       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   2137 AA;  240352 MW;  B37C9A71A09B4528 CRC64;
     MSSRDRTPPK PTSPQLIPLQ DLSRPPDNPP SASEEPSTST RGIFGHGHRH SRTRSLLTGR
     RAPNYARLDG DSPTRTGLSR EGVGLSIRGG SGRDSPLEDA EGFAAATVGL ELPHPSTPPI
     ARMRRPTIIT TPADGEGNDH EAESMFSPPD NDTTPLTEGQ RAPSLKTSSS TSRDQPHDRK
     RRASVRWLDG ESPSLVRGRA NSRLGDDLPT LETNAAIHRK LSTGSSIGRK GSSAVDDSSE
     RSRSLSPSPS PIMARANSML REISQRVVNL SNDSDMVERS IRRKSSVRER RPSTSVSPMA
     DEELAPPPES PLEKVPSMEA LPVPVQPMYH PNPLLGKTWG IFGPENKLRK WLCEILVHPW
     TEPIILLLII TQTVLLAVNA ASRAVYLQTR KEAWGSTGFD YAIFALFIIY TLELIARTIV
     SGFISNPREF STINRSVGVR KAVLQKAHTL LAPQHDRQVP SMANEAPSQP SIVRTFTGLP
     EPGGPGHTKQ QQRIRLARRA FLRHSFNRLD FVAVVSYWIS FVMQIGGIED SSHVYVFNML
     SCLRILRLLG LTAGTSIILR SLKKAAPLLV HVAFLICFFW LIFGIIGVQS FKSSLRRTCV
     WVGDDGSGQN YTQNVAPDNI QFCGGYLNAQ TGEPMPWLKL DGRNGTGTPK GYLCPQNSIC
     VEGSQSPYNG TVSFDNIAQS LELVFVIISS NTFSDLLYYL TDSDYLAAAL FFAAGIVVLS
     LWLVNLLVAV ITSSFQIIRE ESKQSAFTAE KIDGPHLDED PLANRSQLKK MFDKTHWFWI
     LLIVYDLVVQ SLRSSRMSET RRSFIMNSET VVTLLLLIEI ILRFLCDWRH FFRGKRNCFD
     LFLAVVTTII QIPPIRNSGA AYDWLTAFQI ARIYRVVLAV RVTRELVMIV FGNIVGLLNL
     ILFVFLFAFL AAILASQLFR GDYPPVDPSG ETIPVTFFDI WNSFLGMYQV FSSENWTELM
     YNATQFNLIW NTAWLSAIFF ILWFIISNLI VLNMFIAVIQ ESFDVSEDEK RLQQVKAFLK
     QKEISGSASG NLTLAAVFKM GRESIRHRDA LEYGSATVEQ LLKEAVVKDF LDEQEGGLQK
     RPTSMHLPQH IAVKPGLISK YWGKITGLNS HKEPNPFYSN AHVTRANEEF DPRAAAKRVV
     MTTENRRRAQ RQYLQRHPKY NVSLFIFKPH NPIRRMCQYL VGPGRGSERV EGVSPYRPAW
     YAFSAFTYAA IVAMVILACI TTPLYQREYY LNNNLSITNW FVWTDLGFAI LFSVEAIIKA
     IADGLFFTPH AYFRSVWGFI DGVVLITLWI NVITTMFRDD GVSRAVGAFK ALRALRLLNI
     SDTARDTFYS VIIIGGYKVL AAAFVSMSLL IPFAILGVNL FNGKMQACND GDFGYSALSN
     CVGEYNSTPF NWPVLAPRQV ANPWFSFDDF GSALFILFQI VSQEGWVSVM WSGTSITGRG
     LQPQPFASQG NAVYFIIFNL LGAVFVLTLF ISVFMRNYTE QTGVAFLTAE QRSWLELRKL
     LKQISPSKRS IRERSASWQK WCYNLSIKKR GKWQRFITTV LVLHLILLTI DFYPEPSWWE
     TLREGIFLMF TIILIANIAI RIFGLGWQRF RRSAWDIYSI FAVSGIFITS LIALARVTNN
     SRGFDQLHKL FLVSVSFLLI PRNNQLDQLF KTAAASLPLI ANLLATWSVL FLVYAIAFTQ
     TFGLTRFGDN ESNNVNFRTV PKALILLFRT SIGEGWNQIM EDYAGITPPL CVREASFFDS
     DCGSSSWARA LFISWNIISM YIFVSLFVSM IFESFSYVYQ QSSGMSIVSR DEIRRFKQAW
     ADFDPNGTGY ISKEQFPRLL GELSGVFSMR IYDGDFTVQS IKEDCSVKPG DSVRPGARIV
     EGIDLDKLAE RVNQIPVAEI RRRRERMNVF YHEVMLTADP DRGIPFTACL FLLAHYNVIT
     DSRSLRLEEF LRRRARLQRV QETIRRNTVV GFFDTLHWSR KFKQAREMRR NSRLGGPPSL
     PVPEIFIDNP DDAIEEGSSS AAQPHDFTSS TPTYNTPKKQ AAPSLPPIDT SFQPRDSLRS
     AWSFVPDDSP RSSPVRSPRS PGFDPTDRSY SPGASPTATT PRPSLSHSRH GSTATTTTGG
     LGEHGIMESF DASAWGESIR RSFTTRRSRS ERSDRIQ
//
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