ID H6C8V4_EXODN Unreviewed; 971 AA.
AC H6C8V4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE SubName: Full=Ca2+/calmodulin-dependent protein kinase {ECO:0000313|EMBL:EHY60531.1};
GN ORFNames=HMPREF1120_08487 {ECO:0000313|EMBL:EHY60531.1};
OS Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black
OS yeast) (Wangiella dermatitidis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=858893 {ECO:0000313|EMBL:EHY60531.1, ECO:0000313|Proteomes:UP000007304};
RN [1] {ECO:0000313|EMBL:EHY60531.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NIH/UT8656 {ECO:0000313|EMBL:EHY60531.1};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Wang Z., Hunicke-Smith S., Szanislo P.J., Earl A., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Exophiala (Wangiella) dermatitidis NIH/UT8656.";
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR3/UTP12 family.
CC {ECO:0000256|ARBA:ARBA00038229}.
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DR EMBL; JH226136; EHY60531.1; -; Genomic_DNA.
DR RefSeq; XP_009160992.1; XM_009162744.1.
DR AlphaFoldDB; H6C8V4; -.
DR STRING; 858893.H6C8V4; -.
DR GeneID; 20313126; -.
DR VEuPathDB; FungiDB:HMPREF1120_08487; -.
DR eggNOG; KOG0306; Eukaryota.
DR HOGENOM; CLU_005318_0_1_1; -.
DR InParanoid; H6C8V4; -.
DR OMA; MQCLRTV; -.
DR OrthoDB; 168440at2759; -.
DR Proteomes; UP000007304; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProt.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 5.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR007148; SSU_processome_Utp12.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19853; WD REPEAT CONTAINING PROTEIN 3 WDR3; 1.
DR PANTHER; PTHR19853:SF0; WD REPEAT-CONTAINING PROTEIN 3; 1.
DR Pfam; PF04003; Utp12; 1.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 11.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 7.
DR PROSITE; PS50294; WD_REPEATS_REGION; 4.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:EHY60531.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007304};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000313|EMBL:EHY60531.1};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 84..110
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 111..144
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 189..215
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 426..466
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 507..541
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 606..647
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 695..727
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 835..933
FT /note="Small-subunit processome Utp12"
FT /evidence="ECO:0000259|Pfam:PF04003"
FT REGION 322..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..350
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 971 AA; 107602 MW; 75372E9C6AA70E1C CRC64;
MVKSYLKFQH SKTFGQICTA SANVVWDSAA GHEGSTSRGG AGRAYVGANE EVLAWDLKTS
EKVGSWNVED NNALVTVICR SDVDPDVFAV GYEDGKIRIW DSRTATVIIT FNGHKTAVTQ
LKFDRSGVRL ASGSRDTDII LWDLVAEVGL YRLRGHKDQI TSLNFLTADD DDNLLQDGHD
EEQDGNKDSD KFLLSTSKDA LIKVWDLSTQ HCIETHVTQT NGECWALGLT KDGNGCITAG
NDGELKVWSI NQSAMVAKLG ASDQAQLSVL QECGVLYRQG RDRPLAIHFH PKRDLIAVHG
SDKSVELLRI RSESEVRKAL IRKRKRRKGK GDKEVDGEAG ADVADDDHDS NDISAATATD
IFVPYVIVRT GGKVRSIAWA GEKAGKSIHI LVATANNQLE LFDVTTTDKK KSTEAAEYSR
TLSVDMPGHR TDVRCVALSS DDRMLATASH GSLKIWNART QSCLRTLECG YALCMSFLPG
DKIVVVGTRE GTLEVFDIAA STLLDTIHAH ERDIWSLQVS PDGKSLVTGS ADKTAKFWQF
KVVQEEVLGT TRKNAKLTLV HSRTLKVADD ILSVRFSPDE RLLAVSTLDN TVKVFFVDTL
KLFLTLYGHK LPVLSMDISY DSKLIVTSSA DKNVRVWGLD FGDCHKAFFA HQDSILSVLF
VPNNNEGNGH HFFSASKDRI IKYYDADKFE QIQKLDGHHG EIWAMAIAHS GDFLVSASHD
KSIRLWQQTD EQIFLEEERE KELEELYENT LLTSLDNDDT QANGDADGVE ATAAGKQTAQ
TLMAGEKIAE ALEVGLEDLH LMQQYEEAKR TNPKVAMPQR DAVFLANNNV SASVYVLGVF
QRVPSASLQD ALLVLSFSQL PALFTFLALW ASEGRNIPLT CRILFFMLKV HQKQIVSTRT
MRVMLEDLGQ KLRHTLEQQK HDLGFNLAGL RVLGRKVREL GESDYVDDLL LEDSRPSNSN
RGVKRGFVNV A
//
