ID   H6CA62_EXODN            Unreviewed;       599 AA.
AC   H6CA62;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 42.
DE   SubName: Full=Aromatic-L-amino-acid decarboxylase {ECO:0000313|EMBL:EHY60026.1};
GN   ORFNames=HMPREF1120_08001 {ECO:0000313|EMBL:EHY60026.1};
OS   Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black
OS   yeast) (Wangiella dermatitidis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX   NCBI_TaxID=858893 {ECO:0000313|EMBL:EHY60026.1, ECO:0000313|Proteomes:UP000007304};
RN   [1] {ECO:0000313|EMBL:EHY60026.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NIH/UT8656 {ECO:0000313|EMBL:EHY60026.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Cuomo C., Wang Z., Hunicke-Smith S., Szanislo P.J., Earl A., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA   Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA   Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A.,
RA   Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Exophiala (Wangiella) dermatitidis NIH/UT8656.";
RL   Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
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DR   EMBL; JH226136; EHY60026.1; -; Genomic_DNA.
DR   RefSeq; XP_009160487.1; XM_009162239.1.
DR   AlphaFoldDB; H6CA62; -.
DR   STRING; 858893.H6CA62; -.
DR   GeneID; 20312640; -.
DR   VEuPathDB; FungiDB:HMPREF1120_08001; -.
DR   eggNOG; KOG2404; Eukaryota.
DR   HOGENOM; CLU_011398_4_5_1; -.
DR   InParanoid; H6CA62; -.
DR   OMA; QGVENRI; -.
DR   OrthoDB; 1605658at2759; -.
DR   Proteomes; UP000007304; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   Gene3D; 3.90.700.10; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
DR   InterPro; IPR003953; FAD-binding_2.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR010960; Flavocytochrome_c.
DR   InterPro; IPR027477; Succ_DH/fumarate_Rdtase_cat_sf.
DR   NCBIfam; TIGR01813; flavo_cyto_c; 1.
DR   PANTHER; PTHR43400; FUMARATE REDUCTASE; 1.
DR   PANTHER; PTHR43400:SF1; FUMARATE REDUCTASE; 1.
DR   Pfam; PF00890; FAD_binding_2; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   SUPFAM; SSF56425; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
PE   4: Predicted;
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007304};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          77..570
FT                   /note="FAD-dependent oxidoreductase 2 FAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF00890"
FT   REGION          256..278
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          398..425
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   599 AA;  63671 MW;  4D79DDA7B3301342 CRC64;
     MRLPPGHQQQ RATVRRQQHQ YQQHFLSILT LCSVIVVLLI SMTSIPRRIL SKMATATASI
     STTTTSASGL APGSSRVIVV GSGLAGLSAA SELASRNVPV CILERQAKPG GNSIKASSGI
     NGTPTRFQQA AKVDQDSAAV FYDDTTRSVS EKVLTSDPSM TERRKSLIST LTNSSAAAIE
     WLVDDKKIDL SRVAQLGGHT YPRTHRGAGT TPPGASIVLT LLKQLKENPL VSLETGTTVT
     KVIKNSTTSQ VVGVEVRRDG NNSSTSTTTG TETTTTGSSA QVETEILQGP VIFASGGFAG
     DSKGVLAQYR PDLAGYPSTN EALPGSQSLL TDVGAALLDM DLVQLHPTGF IDPHDPLKIT
     KFLAAEMLRG EGGILLRRGK RFVDELQTRK VVTEAITAED PTSSTSETST ISTASTSTTA
     TGDNDSSTAI KQWDISLVLD QGAYEAAKAH VDFYLWKGLM RKTTIADLDP EHTDVALESI
     RQYAGVVKTH GHDDLGRSSY GNWTLFDPGP SSTVYIGKVT PVVHYTMGGV VFDSEARVLD
     GTKTPIEGLW AAGEITGGVH GANRLGGSSL LECVVFGRIA GRNAAEYYYQ RKQEQSSGD
//