ID H6D5A0_STRA4 Unreviewed; 518 AA.
AC H6D5A0; A0A0B5ER48;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=beta-N-acetylhexosaminidase {ECO:0000256|ARBA:ARBA00012663};
DE EC=3.2.1.52 {ECO:0000256|ARBA:ARBA00012663};
GN ORFNames=SLNWT_0246 {ECO:0000313|EMBL:AJE80622.1};
OS Streptomyces albus (strain ATCC 21838 / DSM 41398 / FERM P-419 / JCM 4703 /
OS NBRC 107858).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1081613 {ECO:0000313|EMBL:AEZ53976.1};
RN [1] {ECO:0000313|EMBL:AEZ53976.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=XM211 {ECO:0000313|EMBL:AEZ53976.1};
RX PubMed=22156425; DOI=10.1128/AEM.06701-11;
RA Jiang C., Wang H., Kang Q., Liu J., Bai L.;
RT "Cloning and Characterization of the Polyether Salinomycin Biosynthesis
RT Gene Cluster of Streptomyces albus XM211.";
RL Appl. Environ. Microbiol. 78:994-1003(2012).
RN [2] {ECO:0000313|EMBL:AJE80622.1, ECO:0000313|Proteomes:UP000031523}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 21838 / DSM 41398 / FERM P-419 / JCM 4703 / NBRC 107858
RC {ECO:0000313|Proteomes:UP000031523}, and DSM 41398
RC {ECO:0000313|EMBL:AJE80622.1};
RA Lu C.;
RT "Enhanced salinomycin production by adjusting the supply of polyketide
RT extender units in Streptomyce albus DSM 41398.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JN033543; AEZ53976.1; -; Genomic_DNA.
DR EMBL; CP010519; AJE80622.1; -; Genomic_DNA.
DR AlphaFoldDB; H6D5A0; -.
DR KEGG; sals:SLNWT_0246; -.
DR Proteomes; UP000031523; Chromosome.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd06563; GH20_chitobiase-like; 1.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR015882; HEX_bac_N.
DR PANTHER; PTHR22600; BETA-HEXOSAMINIDASE; 1.
DR PANTHER; PTHR22600:SF21; BETA-HEXOSAMINIDASE A; 1.
DR Pfam; PF00728; Glyco_hydro_20; 1.
DR Pfam; PF02838; Glyco_hydro_20b; 1.
DR PRINTS; PR00738; GLHYDRLASE20.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000031523}.
FT DOMAIN 8..136
FT /note="Beta-hexosaminidase bacterial type N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02838"
FT DOMAIN 140..483
FT /note="Glycoside hydrolase family 20 catalytic"
FT /evidence="ECO:0000259|Pfam:PF00728"
FT ACT_SITE 315
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR625705-1"
SQ SEQUENCE 518 AA; 56353 MW; C458B4D79BAEB7F2 CRC64;
MHLHRPELAL VPRPRFLSAH RTGAFRLDTG TGLRLGPGTE PAARLLRTLL APATGLPLPA
AADGAFVLVL DPALSGLGEE GYGLTVSPHR VLLRAARPAG LLRGVQTVRQ LLPPQALAAD
PQPGVEWALP CVEISDVPRH PWRGAMLDVA RHFQPVSYLR RYVDLLALHK LNVFHLHLTD
DQGWRMPVAA HPRLTEIGGH RAESMIGPSR STRYDGTPHG GAYTAAELRE LVAYAAARGV
TVVPEIEMPG HVRAALAAYP ELGNDPGSTL DVWTRWGVCE NTLGVSDHVL DFFRTVLDET
MEIFPSEHVH IGGDECPTTE WERSPAALDR VRREGLAGPG ALHPWFMQRM TDHLVRAGRR
PVAWAENGTT LPEECTVMSW REPAHAWAAA RRGQHVVFAD HRATYFDYAR EEGDPGLLAQ
SGLVVDLPAV HGLDLTPPGD GAAAADRVLG ASGQLWTELV ATPAHIEYLV YPRLCALADR
VWGGAGDYAD FTARLDGHRT RLDALEVPHA RPPFATAA
//
