ID   H6L2C6_SAPGL            Unreviewed;       753 AA.
AC   H6L2C6;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 48.
DE   SubName: Full=Zn-dependent aminopeptidase {ECO:0000313|EMBL:AFC24764.1};
GN   OrderedLocusNames=SGRA_2033 {ECO:0000313|EMBL:AFC24764.1};
OS   Saprospira grandis (strain Lewin).
OC   Bacteria; Bacteroidota; Saprospiria; Saprospirales; Saprospiraceae;
OC   Saprospira.
OX   NCBI_TaxID=984262 {ECO:0000313|EMBL:AFC24764.1, ECO:0000313|Proteomes:UP000007519};
RN   [1] {ECO:0000313|EMBL:AFC24764.1, ECO:0000313|Proteomes:UP000007519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Lewin {ECO:0000313|EMBL:AFC24764.1,
RC   ECO:0000313|Proteomes:UP000007519};
RX   PubMed=22675601; DOI=10.4056/sigs.2445005;
RA   Saw J.H., Yuryev A., Kanbe M., Hou S., Young A.G., Aizawa S., Alam M.;
RT   "Complete genome sequencing and analysis of Saprospira grandis str. Lewin,
RT   a predatory marine bacterium.";
RL   Stand. Genomic Sci. 6:84-93(2012).
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DR   EMBL; CP002831; AFC24764.1; -; Genomic_DNA.
DR   RefSeq; WP_015692384.1; NC_016940.1.
DR   AlphaFoldDB; H6L2C6; -.
DR   STRING; 984262.SGRA_2033; -.
DR   KEGG; sgn:SGRA_2033; -.
DR   eggNOG; COG0308; Bacteria.
DR   HOGENOM; CLU_015077_0_0_10; -.
DR   OrthoDB; 9814383at2; -.
DR   Proteomes; UP000007519; Chromosome.
DR   GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd09604; M1_APN_like; 1.
DR   Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR   InterPro; IPR014782; Peptidase_M1_dom.
DR   InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR   PANTHER; PTHR11533:SF303; AMINOPEPTIDASE N; 1.
DR   PANTHER; PTHR11533; PROTEASE M1 ZINC METALLOPROTEASE; 1.
DR   Pfam; PF01433; Peptidase_M1; 1.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE   4: Predicted;
KW   Aminopeptidase {ECO:0000313|EMBL:AFC24764.1};
KW   Hydrolase {ECO:0000313|EMBL:AFC24764.1};
KW   Protease {ECO:0000313|EMBL:AFC24764.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007519};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..753
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003603816"
FT   DOMAIN          364..561
FT                   /note="Peptidase M1 membrane alanine aminopeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF01433"
SQ   SEQUENCE   753 AA;  88845 MW;  C6AAC0E1420702B0 CRC64;
     MLKRSLLAIL GLFLLAQYGW AQEERAHEKF KQLYEELPTP NQYHNAAGAP GHKYWQQRAD
     YNIQVRLDDE KQRIYGKERI AYYNNSPDEL SYLWLQLDQN VRAQGSDAQI TETQKLDPQM
     YSYQVMSLFD KFDGGFKIEK VSGKKGENLK YTINKTMMRI DLDRPLKPGE KFEFDVKWWY
     NINDGIKTRA RSGYEYFPED DNYMYNIAQF YPRMCAYNSV DGWQNKQFMG RGEFTLSFGN
     FNLEITVPKN FIVGATGVLQ NSKDVLSKTQ RERIEKARTA KDPVFIITEE EAKANESKKG
     EGSQTWRFYA SNVRDVAFVA SRKLIWDAQG VQFGDRNVLA ISYYPKECMG LWDKYSTRAV
     VHTLKTYSKY TFDYPYPVAI SSHANFTGME YPMICFNYGR PRPDGTYSER LKYGMIGVII
     HEIGHNYFPM IVNSDERQWT WMDEGLNTFL QYLTEVEWER DYPCRRGPAY KITDYMGGDK
     NGIVPIMTNS ESILQFGNNA YGKPATALNI LRETIMGREL FDHAFKEYAN RWKFKHPTPA
     DFFRTMEDAS GVDLDWFWRG WFYGTDHVDI ALDEITHYHL NTFNPEQEMS MQKIWDAEDP
     TYIGDIRNKE SVKQTVMERY PDLRDKYNDR DKYRVDEETQ RNSLFAYQNL SAEEKEVLAK
     DYNYYQVDFK NVGGLVMPII IELKYVDGSS EVRYIPAEIW RYNSNKVSKV FVTEKEIKEF
     ILDPYLETAD VERENNYFPR RRKPTRFEMF SPR
//