ID H6L3W7_SAPGL Unreviewed; 332 AA.
AC H6L3W7;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Cobalamin synthesis protein CobW {ECO:0000313|EMBL:AFC23849.1};
GN OrderedLocusNames=SGRA_1114 {ECO:0000313|EMBL:AFC23849.1};
OS Saprospira grandis (strain Lewin).
OC Bacteria; Bacteroidota; Saprospiria; Saprospirales; Saprospiraceae;
OC Saprospira.
OX NCBI_TaxID=984262 {ECO:0000313|EMBL:AFC23849.1, ECO:0000313|Proteomes:UP000007519};
RN [1] {ECO:0000313|EMBL:AFC23849.1, ECO:0000313|Proteomes:UP000007519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Lewin {ECO:0000313|EMBL:AFC23849.1,
RC ECO:0000313|Proteomes:UP000007519};
RX PubMed=22675601; DOI=10.4056/sigs.2445005;
RA Saw J.H., Yuryev A., Kanbe M., Hou S., Young A.G., Aizawa S., Alam M.;
RT "Complete genome sequencing and analysis of Saprospira grandis str. Lewin,
RT a predatory marine bacterium.";
RL Stand. Genomic Sci. 6:84-93(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. ZNG1
CC subfamily. {ECO:0000256|ARBA:ARBA00034320}.
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DR EMBL; CP002831; AFC23849.1; -; Genomic_DNA.
DR RefSeq; WP_015691497.1; NC_016940.1.
DR AlphaFoldDB; H6L3W7; -.
DR STRING; 984262.SGRA_1114; -.
DR KEGG; sgn:SGRA_1114; -.
DR eggNOG; COG0523; Bacteria.
DR HOGENOM; CLU_017452_0_1_10; -.
DR OrthoDB; 9808822at2; -.
DR Proteomes; UP000007519; Chromosome.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd03112; CobW-like; 1.
DR Gene3D; 3.30.1220.10; CobW-like, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR036627; CobW-likC_sf.
DR InterPro; IPR011629; CobW-like_C.
DR InterPro; IPR003495; CobW/HypB/UreG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13748:SF62; COBW DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR13748; COBW-RELATED; 1.
DR Pfam; PF02492; cobW; 1.
DR Pfam; PF07683; CobW_C; 1.
DR SMART; SM00833; CobW_C; 1.
DR SUPFAM; SSF90002; Hypothetical protein YjiA, C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000007519}.
FT DOMAIN 232..326
FT /note="CobW C-terminal"
FT /evidence="ECO:0000259|SMART:SM00833"
SQ SEQUENCE 332 AA; 37636 MW; 4E93A4CB2F6205AC CRC64;
MDKRIPVTII TGFLGSGKTT LLNELIQRYP EKKLAIIENE FGELGIDQDL VVRGEDQIFE
LSNGCICCSL NDELVDTLAK LLNGNYDFDH LLIETTGIAE PDAIAAAFVA DASVQAYFQL
DAVICLADAQ YTLDSLAERE EAKRQLAFAD LILLNKKSSV SEEQLEQTKA GLKKLNPLAE
IIEADYGKTE RNLLDLQAYA FATVEEKLKA QHQPKTCSHG SHHHHHHEQG ELVTHSFIFD
QPFDLLKLRH WLQVLLMLQG EGIYRVKGVL WVQWQDKKMV LQSVRKSFAL QLGEDWPEDK
PRQSRIVFIG KNLRKDILEK SLKQLLALET SF
//
