ID H6LB15_SAPGL Unreviewed; 385 AA.
AC H6LB15;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=3-hydroxybutyryl-CoA dehydrogenase {ECO:0000313|EMBL:AFC26980.1};
DE EC=1.1.1.157 {ECO:0000313|EMBL:AFC26980.1};
GN Name=paaH {ECO:0000313|EMBL:AFC26980.1};
GN ORFNames=SGRA_p0040 {ECO:0000313|EMBL:AFC26980.1};
OS Saprospira grandis (strain Lewin).
OG Plasmid SGRA01 {ECO:0000313|Proteomes:UP000007519}.
OC Bacteria; Bacteroidota; Saprospiria; Saprospirales; Saprospiraceae;
OC Saprospira.
OX NCBI_TaxID=984262 {ECO:0000313|EMBL:AFC26980.1, ECO:0000313|Proteomes:UP000007519};
RN [1] {ECO:0000313|EMBL:AFC26980.1, ECO:0000313|Proteomes:UP000007519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Lewin {ECO:0000313|EMBL:AFC26980.1,
RC ECO:0000313|Proteomes:UP000007519};
RC PLASMID=Plasmid SGRA01 {ECO:0000313|Proteomes:UP000007519};
RX PubMed=22675601; DOI=10.4056/sigs.2445005;
RA Saw J.H., Yuryev A., Kanbe M., Hou S., Young A.G., Aizawa S., Alam M.;
RT "Complete genome sequencing and analysis of Saprospira grandis str. Lewin,
RT a predatory marine bacterium.";
RL Stand. Genomic Sci. 6:84-93(2012).
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DR EMBL; CP002832; AFC26980.1; -; Genomic_DNA.
DR RefSeq; WP_015695534.1; NC_016936.1.
DR AlphaFoldDB; H6LB15; -.
DR KEGG; sgn:SGRA_p0040; -.
DR eggNOG; COG1250; Bacteria.
DR HOGENOM; CLU_009834_2_0_10; -.
DR OrthoDB; 9771883at2; -.
DR Proteomes; UP000007519; Plasmid SGRA01.
DR GO; GO:0008691; F:3-hydroxybutyryl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006180; 3-OHacyl-CoA_DH_CS.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00067; 3HCDH; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:AFC26980.1};
KW Plasmid {ECO:0000313|EMBL:AFC26980.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007519}.
FT DOMAIN 2..181
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 183..280
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 299..380
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 385 AA; 42366 MW; 68C06F8D82C35295 CRC64;
MKVAVIGAGA MGSGIAQIAA TQGHSVYLYD KFPQALEKAL GKLKKILNRL VEKGRLGQEE
AEAIYGRIEP ISELEKLADS GLVIEAIVEN LEIKKAVFQE LESLVAKDCI LASNTSSLSI
ASIAAACQQS ERVLGIHFFN PAPLMKLVEI IPAVQTADAV TQKAKAIIDG WGKLTVLAKD
TPGFIVNRVA RPFYGEALRI LEEGIADVAT IDWAMKELGG FRMGPFTLMD YIGNDINYTV
TETVFKAFYY DPRYKPAFTQ KRLAEAGFLG RKTGRGYYDY AEGATAPAPQ KEEILGQQIL
HRIVVMLINE AADALFWQVA SAKDIDLAMT KGVNYPKGLL AWANELGAAH CVEQLDALYD
TYREDRYRCS PLLRRMAQEN TSFDV
//
