ID H6Q5B9_WIGGL Unreviewed; 321 AA.
AC H6Q5B9;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 13-SEP-2023, entry version 54.
DE RecName: Full=Signal peptidase I {ECO:0000256|ARBA:ARBA00019232, ECO:0000256|RuleBase:RU362042};
DE EC=3.4.21.89 {ECO:0000256|ARBA:ARBA00013208, ECO:0000256|RuleBase:RU362042};
GN Name=lepB {ECO:0000313|EMBL:AFA41404.1};
GN ORFNames=WIGMOR_0590 {ECO:0000313|EMBL:AFA41404.1};
OS Wigglesworthia glossinidia endosymbiont of Glossina morsitans morsitans
OS (Yale colony).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Erwiniaceae; Wigglesworthia.
OX NCBI_TaxID=1142511 {ECO:0000313|EMBL:AFA41404.1, ECO:0000313|Proteomes:UP000009061};
RN [1] {ECO:0000313|EMBL:AFA41404.1, ECO:0000313|Proteomes:UP000009061}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WGM {ECO:0000313|EMBL:AFA41404.1};
RX PubMed=22334516;
RA Rio R.V., Symula R.E., Wang J., Lohs C., Wu Y.N., Snyder A.K.,
RA Bjornson R.D., Oshima K., Biehl B.S., Perna N.T., Hattori M., Aksoy S.;
RT "Insight into the transmission biology and species-specific functional
RT capabilities of tsetse (Diptera: glossinidae) obligate symbiont
RT wigglesworthia.";
RL MBio 3:E00240-11(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Cleavage of hydrophobic, N-terminal signal or leader sequences
CC from secreted and periplasmic proteins.; EC=3.4.21.89;
CC Evidence={ECO:0000256|ARBA:ARBA00000677,
CC ECO:0000256|RuleBase:RU362042};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362042}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362042}.
CC -!- SIMILARITY: Belongs to the peptidase S26 family.
CC {ECO:0000256|ARBA:ARBA00009370, ECO:0000256|RuleBase:RU362042}.
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DR EMBL; CP003315; AFA41404.1; -; Genomic_DNA.
DR RefSeq; WP_014354343.1; NC_016893.1.
DR AlphaFoldDB; H6Q5B9; -.
DR STRING; 1142511.WIGMOR_0590; -.
DR MEROPS; S26.001; -.
DR KEGG; wgl:WIGMOR_0590; -.
DR eggNOG; COG0681; Bacteria.
DR HOGENOM; CLU_028723_1_1_6; -.
DR OrthoDB; 9815782at2; -.
DR Proteomes; UP000009061; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006465; P:signal peptide processing; IEA:InterPro.
DR CDD; cd06530; S26_SPase_I; 1.
DR Gene3D; 2.170.230.10; -; 1.
DR Gene3D; 2.10.109.10; Umud Fragment, subunit A; 1.
DR InterPro; IPR036286; LexA/Signal_pep-like_sf.
DR InterPro; IPR000223; Pept_S26A_signal_pept_1.
DR InterPro; IPR019758; Pept_S26A_signal_pept_1_CS.
DR InterPro; IPR019757; Pept_S26A_signal_pept_1_Lys-AS.
DR InterPro; IPR019533; Peptidase_S26.
DR InterPro; IPR019766; Sign_pep_all-beta_subdom.
DR NCBIfam; TIGR02227; sigpep_I_bact; 2.
DR PANTHER; PTHR43390:SF1; CHLOROPLAST PROCESSING PEPTIDASE; 1.
DR PANTHER; PTHR43390; SIGNAL PEPTIDASE I; 1.
DR Pfam; PF10502; Peptidase_S26; 1.
DR PRINTS; PR00727; LEADERPTASE.
DR SUPFAM; SSF51306; LexA/Signal peptidase; 1.
DR PROSITE; PS00760; SPASE_I_2; 1.
DR PROSITE; PS00761; SPASE_I_3; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|RuleBase:RU362042};
KW Membrane {ECO:0000256|RuleBase:RU362042};
KW Protease {ECO:0000256|RuleBase:RU362042};
KW Transmembrane {ECO:0000256|RuleBase:RU362042};
KW Transmembrane helix {ECO:0000256|RuleBase:RU362042}.
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362042"
FT TRANSMEM 52..76
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362042"
FT DOMAIN 56..299
FT /note="Peptidase S26"
FT /evidence="ECO:0000259|Pfam:PF10502"
FT ACT_SITE 86
FT /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
FT ACT_SITE 141
FT /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
SQ SEQUENCE 321 AA; 37208 MW; 8B869EB4C28168FA CRC64;
MINLFSLLLI SITLITGILW VFIKFLKNKI YKIQLNSDAK YNKLIQFTKN KYFTWIHSIA
SMFPGLLLVI IVRFFLFEPF QIPSGSMMPN LLIGDFILVN KFIYGIKEPI TQNTMISVNS
PCRGDVIVFK YPLNNKLDYI KRVVGIPGDK ISYNPINKEI TIQPQVISKH TISSSRSLST
TYSYSVPSIF VQTLLFQKKN QINNEFIELD FNKPVSMGIR MLLKKEKIEN HSHDILTLPI
YQDQLNNYYA QSNQSLGNWV VPNGNYFVMG DNRDNSSDSR YWGFVPEKNV VGKAFLIWMS
LEKKENQWPT GIRIHRIGKI Q
//
