ID H6QY55_NOCCG Unreviewed; 284 AA.
AC H6QY55;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=2,5-diketo-D-gluconate reductase A {ECO:0000313|EMBL:CCF61503.1};
GN Name=dkgA {ECO:0000313|EMBL:CCF61503.1};
GN OrderedLocusNames=NOCYR_0689 {ECO:0000313|EMBL:CCF61503.1};
OS Nocardia cyriacigeorgica (strain GUH-2).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=1127134 {ECO:0000313|EMBL:CCF61503.1, ECO:0000313|Proteomes:UP000008190};
RN [1] {ECO:0000313|EMBL:CCF61503.1, ECO:0000313|Proteomes:UP000008190}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GUH-2 {ECO:0000313|EMBL:CCF61503.1,
RC ECO:0000313|Proteomes:UP000008190};
RX PubMed=22461543; DOI=10.1128/JB.00161-12;
RA Zoropogui A., Pujic P., Normand P., Barbe V., Beaman B., Beaman L.,
RA Boiron P., Colinon C., Deredjian A., Graindorge A., Mangenot S.,
RA Nazaret S., Neto M., Petit S., Roche D., Vallenet D., Rodriguez-Nava V.,
RA Richard Y., Cournoyer B., Blaha D.;
RT "Genome sequence of the human- and animal-pathogenic strain Nocardia
RT cyriacigeorgica GUH-2.";
RL J. Bacteriol. 194:2098-2099(2012).
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DR EMBL; FO082843; CCF61503.1; -; Genomic_DNA.
DR AlphaFoldDB; H6QY55; -.
DR STRING; 1127134.NOCYR_0689; -.
DR KEGG; ncy:NOCYR_0689; -.
DR eggNOG; COG0656; Bacteria.
DR HOGENOM; CLU_023205_0_1_11; -.
DR Proteomes; UP000008190; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE 4: Predicted;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Reference proteome {ECO:0000313|Proteomes:UP000008190}.
FT DOMAIN 30..267
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 57
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 115
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 82
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 284 AA; 31165 MW; FE1E7C0721BC45EC CRC64;
MTFRSETCAI PSIVLNDGNV IPQLGFGVFQ VPADDVFPVV TAALEAGYRS IDTAAIYGNE
EGTGRAIRQS GIPRDEIYVT TKLWNSEQGY DSTLRAFDAS MQRLGLDYLD LYLIHWPAPS
ADRFVDTFKA FKALKADGRV RSIGVSNFRI PDLERVIGET GEIPAVNQIE LHPRLTQREL
REYHAEHAIA TEAWSPLGQG TLLDHKVITE IAGELDRTPA QVIIRWHLQL GNIVIPKSVT
PSRIVSNFDV FGFELSGEQM AAISALDDGG RVGPDPSTFA AGLD
//
