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Database: UniProt
Entry: H6R588_NOCCG
LinkDB: H6R588_NOCCG
Original site: H6R588_NOCCG 
ID   H6R588_NOCCG            Unreviewed;       721 AA.
AC   H6R588;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   25-OCT-2017, entry version 44.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:CCF60826.1};
GN   OrderedLocusNames=NOCYR_0001 {ECO:0000313|EMBL:CCF60826.1};
OS   Nocardia cyriacigeorgica (strain GUH-2).
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae; Nocardia.
OX   NCBI_TaxID=1127134 {ECO:0000313|EMBL:CCF60826.1, ECO:0000313|Proteomes:UP000008190};
RN   [1] {ECO:0000313|EMBL:CCF60826.1, ECO:0000313|Proteomes:UP000008190}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GUH-2 {ECO:0000313|EMBL:CCF60826.1,
RC   ECO:0000313|Proteomes:UP000008190};
RX   PubMed=22461543; DOI=10.1128/JB.00161-12;
RA   Zoropogui A., Pujic P., Normand P., Barbe V., Beaman B., Beaman L.,
RA   Boiron P., Colinon C., Deredjian A., Graindorge A., Mangenot S.,
RA   Nazaret S., Neto M., Petit S., Roche D., Vallenet D.,
RA   Rodriguez-Nava V., Richard Y., Cournoyer B., Blaha D.;
RT   "Genome Sequence of the Human- and Animal-Pathogenic Strain Nocardia
RT   cyriacigeorgica GUH-2.";
RL   J. Bacteriol. 194:2098-2099(2012).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; FO082843; CCF60826.1; -; Genomic_DNA.
DR   RefSeq; WP_014348303.1; NC_016887.1.
DR   STRING; 1127134.NOCYR_0001; -.
DR   EnsemblBacteria; CCF60826; CCF60826; NOCYR_0001.
DR   KEGG; ncy:NOCYR_0001; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   KO; K02313; -.
DR   OMA; RHARMTS; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000008190; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008190};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008190}.
FT   DOMAIN      415    543       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      627    695       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     423    430       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   721 AA;  79980 MW;  27C649002C247233 CRC64;
     MDDEQNVLAT VWPEVVAELT TGSPDGAIPS VSRAQQAWLK LVKPLTVAQG FALLSVPSSL
     AQEAIERDLR EPILRSLARR LGPQVEGLGV RIAAPTTPGA ERPSAPPRHA RMTSRPERPR
     EPVRRPEFPG VETAGRGEFS PPRYATGNEY APDYPSADYA GGRSYPPGQD YPQGADFERS
     DSYGRADGFA EGGGYGGGDG YDQRDNFEQR DGYGRPEFGR PADFGEAPER RPEPDYRPAP
     EYREAEFPAR GDYPATDAGE PEGRADNAAP PRREPAAAPR RDAVPPGQES LFTPEPAPRI
     PSVTPAREPG PAEEQAPAAA HEPSRDAGDP LREPLRDAVR ESGADGQRPE HDDEPVVNVR
     DSWPTYFAKS QESQAPQTSS ASLNAKYTFE TFVIGASNRF AHAAAVAIAE APARAYNPLF
     VWGASGLGKT HLLHAAGHYA QRLFPGMRVK YVSTEEFTND FINSLRDDRK VAFKRRYRET
     DILLVDDIQF IEGKEGIQEE FFHTFNTLHN ANKQIVVSSD RPPKQLATLE ERLRTRFEWG
     LITDVQPPEL ETRIAILRKK ARMDRLDVPH DVLELIASRV ERNIRELEGA LIRVTAFASL
     NGQPLDLPLA EVVLRDLMPD TAALEITAAT IMAVTAEYFN TTLEELTGPG KARPLAQARQ
     IAMYLCRELT DLSLPKIGQA FGRDHTTVMY AEKKVRKEMT ERRRVYDQVQ ELTARIKQRS
     R
//
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