ID H6RAM7_NOCCG Unreviewed; 650 AA.
AC H6RAM7;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Putative acyl-CoA dehydrogenase {ECO:0000313|EMBL:CCF66238.1};
GN OrderedLocusNames=NOCYR_5491 {ECO:0000313|EMBL:CCF66238.1};
OS Nocardia cyriacigeorgica (strain GUH-2).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=1127134 {ECO:0000313|EMBL:CCF66238.1, ECO:0000313|Proteomes:UP000008190};
RN [1] {ECO:0000313|EMBL:CCF66238.1, ECO:0000313|Proteomes:UP000008190}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GUH-2 {ECO:0000313|EMBL:CCF66238.1,
RC ECO:0000313|Proteomes:UP000008190};
RX PubMed=22461543; DOI=10.1128/JB.00161-12;
RA Zoropogui A., Pujic P., Normand P., Barbe V., Beaman B., Beaman L.,
RA Boiron P., Colinon C., Deredjian A., Graindorge A., Mangenot S.,
RA Nazaret S., Neto M., Petit S., Roche D., Vallenet D., Rodriguez-Nava V.,
RA Richard Y., Cournoyer B., Blaha D.;
RT "Genome sequence of the human- and animal-pathogenic strain Nocardia
RT cyriacigeorgica GUH-2.";
RL J. Bacteriol. 194:2098-2099(2012).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|RuleBase:RU362125};
CC -!- SIMILARITY: Belongs to the acyl-CoA dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009347, ECO:0000256|RuleBase:RU362125}.
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DR EMBL; FO082843; CCF66238.1; -; Genomic_DNA.
DR RefSeq; WP_014353682.1; NC_016887.1.
DR AlphaFoldDB; H6RAM7; -.
DR STRING; 1127134.NOCYR_5491; -.
DR KEGG; ncy:NOCYR_5491; -.
DR eggNOG; COG1960; Bacteria.
DR HOGENOM; CLU_018204_11_1_11; -.
DR OrthoDB; 8876745at2; -.
DR Proteomes; UP000008190; Chromosome.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
DR Gene3D; 1.10.540.10; Acyl-CoA dehydrogenase/oxidase, N-terminal domain; 1.
DR Gene3D; 2.40.110.10; Butyryl-CoA Dehydrogenase, subunit A, domain 2; 1.
DR Gene3D; 1.20.140.10; Butyryl-CoA Dehydrogenase, subunit A, domain 3; 2.
DR InterPro; IPR006091; Acyl-CoA_Oxase/DH_mid-dom.
DR InterPro; IPR046373; Acyl-CoA_Oxase/DH_mid-dom_sf.
DR InterPro; IPR036250; AcylCo_DH-like_C.
DR InterPro; IPR009075; AcylCo_DH/oxidase_C.
DR InterPro; IPR013786; AcylCoA_DH/ox_N.
DR InterPro; IPR037069; AcylCoA_DH/ox_N_sf.
DR InterPro; IPR009100; AcylCoA_DH/oxidase_NM_dom_sf.
DR PANTHER; PTHR43884; ACYL-COA DEHYDROGENASE; 1.
DR PANTHER; PTHR43884:SF12; COMPLEX I ASSEMBLY FACTOR ACAD9, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF00441; Acyl-CoA_dh_1; 1.
DR Pfam; PF02770; Acyl-CoA_dh_M; 1.
DR Pfam; PF02771; Acyl-CoA_dh_N; 1.
DR SUPFAM; SSF47203; Acyl-CoA dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF56645; Acyl-CoA dehydrogenase NM domain-like; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|RuleBase:RU362125};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW ECO:0000256|RuleBase:RU362125};
KW Oxidoreductase {ECO:0000256|RuleBase:RU362125};
KW Reference proteome {ECO:0000313|Proteomes:UP000008190}.
FT DOMAIN 66..165
FT /note="Acyl-CoA dehydrogenase/oxidase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02771"
FT DOMAIN 169..267
FT /note="Acyl-CoA oxidase/dehydrogenase middle"
FT /evidence="ECO:0000259|Pfam:PF02770"
FT DOMAIN 279..438
FT /note="Acyl-CoA dehydrogenase/oxidase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00441"
SQ SEQUENCE 650 AA; 70662 MW; C2F11A7482CEAB8A CRC64;
MATTAKVDAT EEQARALVEE SRETGWAKPS FAKEMFLGRF RLDLIHPYPR PTAEDADRTD
EFLARLRPVC ASMDGTVIEE QSRIPDDYVR SLADLGCFGL KIPPDYGGQG LSQYGYNRAL
MLVGSAHPSL GVLLSAHQSI GVPEPLKLAG TEEQKREFLP RCAAGAVSAF LLTEPDVGSD
PARMASTATP TEDGEAYELN GVKLWTTNGV VAELLVVMAR VPKSEGHRGG ISAFVVEADS
PGLTVERRNS FMGLHGIENG VTRMHNVRVP ARNLIGREGD GLKIALTTLN AGRLAIPALC
TAASKWSLKI AREWSTQRVQ WGRPVGEHAA VGAKLSFIAA TTFALEAVLD LSATMADEGR
NDIRIEAALA KLWSSEMSCR IADELVQIRG GRGYETAASL AARGERAVPA EQLVRDLRIN
RIFEGSSEIM RLLIAREMAD AHMAAAGALV DRNAGLEDKA KAAIGAGGFY AKWFPQLAVG
AGTVPASYPE FGPLAKHLRF VERNARKQAR SLMYAMARWQ AGLEYRQNFL GRIVDIGAEL
FAMSAACVRA QDLRTSGAVE ARSATELADT FCQQARLRVK ALFDALWDNT DDEDRALTRG
ILDGNHEWLE DGVLDQSEGT GPWIAEWQFG PSTETNLLRP FLPSTRRVGT
//
