ID H6RC58_NOCCG Unreviewed; 277 AA.
AC H6RC58;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Transcriptional regulator TetR like {ECO:0000313|EMBL:CCF62594.1};
GN OrderedLocusNames=NOCYR_1808 {ECO:0000313|EMBL:CCF62594.1};
OS Nocardia cyriacigeorgica (strain GUH-2).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=1127134 {ECO:0000313|EMBL:CCF62594.1, ECO:0000313|Proteomes:UP000008190};
RN [1] {ECO:0000313|EMBL:CCF62594.1, ECO:0000313|Proteomes:UP000008190}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GUH-2 {ECO:0000313|EMBL:CCF62594.1,
RC ECO:0000313|Proteomes:UP000008190};
RX PubMed=22461543; DOI=10.1128/JB.00161-12;
RA Zoropogui A., Pujic P., Normand P., Barbe V., Beaman B., Beaman L.,
RA Boiron P., Colinon C., Deredjian A., Graindorge A., Mangenot S.,
RA Nazaret S., Neto M., Petit S., Roche D., Vallenet D., Rodriguez-Nava V.,
RA Richard Y., Cournoyer B., Blaha D.;
RT "Genome sequence of the human- and animal-pathogenic strain Nocardia
RT cyriacigeorgica GUH-2.";
RL J. Bacteriol. 194:2098-2099(2012).
CC -!- FUNCTION: TetR is the repressor of the tetracycline resistance element;
CC its N-terminal region forms a helix-turn-helix structure and binds DNA.
CC Binding of tetracycline to TetR reduces the repressor affinity for the
CC tetracycline resistance gene (tetA) promoter operator sites.
CC {ECO:0000256|ARBA:ARBA00002856}.
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DR EMBL; FO082843; CCF62594.1; -; Genomic_DNA.
DR RefSeq; WP_014350059.1; NC_016887.1.
DR AlphaFoldDB; H6RC58; -.
DR STRING; 1127134.NOCYR_1808; -.
DR KEGG; ncy:NOCYR_1808; -.
DR eggNOG; COG1309; Bacteria.
DR HOGENOM; CLU_069543_0_0_11; -.
DR OrthoDB; 4540879at2; -.
DR Proteomes; UP000008190; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 1.10.357.10; Tetracycline Repressor, domain 2; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR004111; Repressor_TetR_C.
DR InterPro; IPR003012; Tet_transcr_reg_TetR.
DR InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR PANTHER; PTHR30055; HTH-TYPE TRANSCRIPTIONAL REGULATOR RUTR; 1.
DR PANTHER; PTHR30055:SF151; HTH-TYPE TRANSCRIPTIONAL REPRESSOR RV1353C; 1.
DR Pfam; PF02909; TetR_C_1; 1.
DR Pfam; PF00440; TetR_N; 1.
DR PRINTS; PR00400; TETREPRESSOR.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF48498; Tetracyclin repressor-like, C-terminal domain; 1.
DR PROSITE; PS50977; HTH_TETR_2; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00335};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008190};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 59..119
FT /note="HTH tetR-type"
FT /evidence="ECO:0000259|PROSITE:PS50977"
FT DNA_BIND 82..101
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00335"
SQ SEQUENCE 277 AA; 30321 MW; FB5AFCC1C6E729AA CRC64;
MAALDACVTC GQPLAHPARG RRRRYCSRSC QARAYRARRD ALIPAHHTAP TRRRATGAPP
TAVTIARTAV ELADRLGLDG LSTRRLAGEL GVTTAALYRH YADRDALLAA MAELVLAEVP
PPPPELTGWR ARVAYEARQE WQLYQRHPWL LPVLARTRPP IGPALFDILE RTFSALDEPA
MTPHEILSIY LALSGLVQGI ALMWSAEYVE RALDPDAQPG EQVQAELAEL LDPAIRPVLG
KLFGTGPPEV DFDAVIDAGI DLLLDGVAAR YRRHPAS
//
