ID   H6RD10_NOCCG            Unreviewed;       586 AA.
AC   H6RD10;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 55.
DE   SubName: Full=Putative peptidoglycan synthetase ftsI (Peptidoglycan glycosyltransferase 3) (Penicillin-binding protein 3) (PBP-3) {ECO:0000313|EMBL:CCF62654.1};
GN   OrderedLocusNames=NOCYR_1868 {ECO:0000313|EMBL:CCF62654.1};
OS   Nocardia cyriacigeorgica (strain GUH-2).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC   Nocardia.
OX   NCBI_TaxID=1127134 {ECO:0000313|EMBL:CCF62654.1, ECO:0000313|Proteomes:UP000008190};
RN   [1] {ECO:0000313|EMBL:CCF62654.1, ECO:0000313|Proteomes:UP000008190}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GUH-2 {ECO:0000313|EMBL:CCF62654.1,
RC   ECO:0000313|Proteomes:UP000008190};
RX   PubMed=22461543; DOI=10.1128/JB.00161-12;
RA   Zoropogui A., Pujic P., Normand P., Barbe V., Beaman B., Beaman L.,
RA   Boiron P., Colinon C., Deredjian A., Graindorge A., Mangenot S.,
RA   Nazaret S., Neto M., Petit S., Roche D., Vallenet D., Rodriguez-Nava V.,
RA   Richard Y., Cournoyer B., Blaha D.;
RT   "Genome sequence of the human- and animal-pathogenic strain Nocardia
RT   cyriacigeorgica GUH-2.";
RL   J. Bacteriol. 194:2098-2099(2012).
CC   -!- SIMILARITY: Belongs to the transpeptidase family.
CC       {ECO:0000256|ARBA:ARBA00007171}.
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DR   EMBL; FO082843; CCF62654.1; -; Genomic_DNA.
DR   AlphaFoldDB; H6RD10; -.
DR   STRING; 1127134.NOCYR_1868; -.
DR   KEGG; ncy:NOCYR_1868; -.
DR   eggNOG; COG0768; Bacteria.
DR   HOGENOM; CLU_009289_6_5_11; -.
DR   Proteomes; UP000008190; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.450.330; -; 1.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008190};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000313|EMBL:CCF62654.1};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..586
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5039463212"
FT   DOMAIN          38..201
FT                   /note="Penicillin-binding protein dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          246..562
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
SQ   SEQUENCE   586 AA;  62504 MW;  6D0A5EE93AE1D9C4 CRC64;
     MLGALAVVAI QLLWVQSISA PGLSAQAASQ RTAHWVDEAM RGPITDRNGK ALAFTVTAKE
     LHFQPVKVRK DLAEAKAKDD SAPDPEQRLR DIAATIHEKL GDKGPSEKKL LELLNSDEPF
     VYLARNVDPR IAAEIVVEFK EVGADSQNPR EYPGDSLAAN IIGAVGWDGH GQIGLESSMD
     SLLAGTDGSH TYDRGADGAV IPGSWRDRVP AVNGYGIELT LDSDLQYYVQ QQVQQAKDLS
     GAQSASAVVL DAKTGQVLAM ANDNTFNPSL GPEHWKPETL DNPSVTHAFE PGSVNKIVTA
     AAAIEYGLTT PDEVHQVPGQ IHMAGVTVGD AWEHGVAPYT TTGIFGKSSN VGTLMLAQRV
     GEDRFADMLQ RFGLGQRTGV GLPGESPGRV PARDQWSGGT FANLPIGQGL SMTTLQMTSM
     YQAIANDGLR IPPRIVRAEI APDKTRTERP TPEGVRVVSP QTAQTLRTMF QAVVQRDPMG
     VQMGTGVPAA IEGYQIAGKT GTAQKVDPAC GCYSTSSYWI TFAGIAPADD PRYVIGMMLD
     APVRSADGSG GQSAAPLFHN IASWALQRDR IPPSTEPARR FVLQAS
//