ID H6UKR8_HUMAN Unreviewed; 350 AA.
AC H6UKR8;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=TOX2 variant 5 {ECO:0000313|EMBL:AFA25746.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AFA25746.1};
RN [1] {ECO:0000313|EMBL:AFA25746.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22496870; DOI=10.1371/journal.pone.0034850;
RA Tessema M., Yingling C.M., Grimes M.J., Thomas C.L., Liu Y., Leng S.,
RA Joste N., Belinsky S.A.;
RT "Differential Epigenetic Regulation of TOX Subfamily High Mobility Group
RT Box Genes in Lung and Breast Cancers.";
RL PLoS ONE 7:E34850-E34850(2012).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; JN655166; AFA25746.1; -; mRNA.
DR AlphaFoldDB; H6UKR8; -.
DR PeptideAtlas; H6UKR8; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd21995; HMG-box_TOX-like; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR PANTHER; PTHR45781; AGAP000281-PA; 1.
DR PANTHER; PTHR45781:SF5; TOX HIGH MOBILITY GROUP BOX FAMILY MEMBER 2; 1.
DR Pfam; PF00505; HMG_box; 1.
DR PRINTS; PR00886; HIGHMOBLTY12.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267}.
FT DOMAIN 204..272
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 204..272
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 141..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 276..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 350 AA; 37495 MW; 505A0A461D2BFF82 CRC64;
MSDGNPELLS TSQTYNGQSE NNEDYEIPPI TPPNLPEPSL LHLGDHEASY HSLCHGLTPN
GLLPAYSYQA MDLPAIMVSN MLAQDSHLLS GQLPTIQEMV HSEVAAYDSG RPGPLLGRPA
MLASHMSALS QSQLISQMGI RSSIAHSSPS PPGSKSATPS PSSSTQEEES EVHFKISGEK
RPSADPGKKA KNPKKKKKKD PNEPQKPVSA YALFFRDTQA AIKGQNPSAT FGDVSKIVAS
MWDSLGEEQK QAYKRKTEAA KKEYLKALAA YRASLVSKSS PDQGETKSTQ ANPPAKMLPP
KQPMYAMPGL ASFLTPSDLQ AFRSGASPAS LARTLGSKSL LPGLRLPAHL
//
