ID H6UZX9_PARLI Unreviewed; 613 AA.
AC H6UZX9;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 08-NOV-2023, entry version 41.
DE SubName: Full=Frizzled 9-10 {ECO:0000313|EMBL:AFA43479.1};
OS Paracentrotus lividus (Common sea urchin).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC Euechinoidea; Echinacea; Camarodonta; Echinidea; Echinidae; Paracentrotus.
OX NCBI_TaxID=7656 {ECO:0000313|EMBL:AFA43479.1};
RN [1] {ECO:0000313|EMBL:AFA43479.1}
RP NUCLEOTIDE SEQUENCE.
RA Croce J.C.;
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AFA43479.1}
RP NUCLEOTIDE SEQUENCE.
RA Guy L., Mcclay D.R., Gache C.;
RT "Frizzled 1/2/7 signaling directs beta-catenin nuclearization and initiates
RT endoderm specification in macromeres during sea urchin embryogenesis.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000256|ARBA:ARBA00008077}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
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DR EMBL; JN712908; AFA43479.1; -; mRNA.
DR AlphaFoldDB; H6UZX9; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15909; 7tmF_FZD4_9_10-like; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF99; FRIZZLED-4; 1.
DR Pfam; PF01534; Frizzled; 1.
DR Pfam; PF01392; Fz; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM00063; FRI; 1.
DR SMART; SM01330; Frizzled; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..613
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003607598"
FT TRANSMEM 236..258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 325..348
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..379
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 404..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 450..473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 513..532
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 32..150
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 234..539
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 158..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 559..600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..579
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 37..98
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 45..91
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 82..120
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 113..137
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 613 AA; 68353 MW; 51686213E86B2DBD CRC64;
MATWSSILVG ILVLCGWCYD GSYGLGVHSR NTQGGYCERI TIEFCQGIGY NNTKMPNLFG
HVTQSEAAPS IHEFHPLVVV GCAEHLRLFL CSMYAPMCSE HVDVRIPPCQ SMCEDVRRKC
EPVMARFSFS WPESMNCGKL PRGKDLCMVA PDTADVDGDT IPTYEPNVNY GGPGDNSASR
PESGGDGQRP SNTTSSAPPT CLNPQKFVFV SQTNSCAPRC DVDVYFQRSD KDFTEMWMGV
WAILCFVCTS ITVLTFLIDR GRFKYPERPI IFLSMCYNIY SITYVVRLIV GPQAVACEKT
SSGVPYLIME GLDTTGCTIV FLIQYYFFMA SSIWWVILTL TWFLAAGMKW GYEAIAAYSS
YYHVVAWALP ALKTIIALAK HRLDADELTG MCYIGNHDPD VLTYYVLVPL FIYFAIGTLF
ILAGFFYLFR IRKVMKNGGT NIDKLERLMV RIGIFSVLYT VPATAVIACY FYQRSNMEYW
RIVAEHAPCR PLPPEEGGGC APMDYSIPSV PVLSVKLFML LVVGITSGMW IWSSKTVQSW
QNWLGRCGLF SPAQKSSFQQ QQLKQQQQQQ PNGGTPNKGN RPPTPRGKYP TINGNNRSTG
IGYSSVNAGS AIV
//
