ID H6VPY2_LEPOC Unreviewed; 323 AA.
AC H6VPY2;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Brain super conserved receptor 2 {ECO:0000313|EMBL:AEZ50079.1};
DE Flags: Fragment;
GN Name=sreb2 {ECO:0000313|EMBL:AEZ50079.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|EMBL:AEZ50079.1};
RN [1] {ECO:0000313|EMBL:AEZ50079.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22445447; DOI=10.1016/j.ympev.2012.02.033;
RA Wright J.J., David S.R., Near T.J.;
RT "Gene trees, species trees, and morphology converge on a similar phylogeny
RT of living gars (Actinopterygii: Holostei: Lepisosteidae), an ancient clade
RT of ray-finned fishes.";
RL Mol. Phylogenet. Evol. 63:848-856(2012).
CC -!- FUNCTION: Orphan receptor. {ECO:0000256|ARBA:ARBA00035627}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; JN853497; AEZ50079.1; -; Genomic_DNA.
DR EMBL; JN853498; AEZ50080.1; -; Genomic_DNA.
DR AlphaFoldDB; H6VPY2; -.
DR HOGENOM; CLU_055518_0_0_1; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15218; 7tmA_SREB2_GPR85; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR19268; G PROTEIN-COUPLED RECEPTOR; 1.
DR PANTHER; PTHR19268:SF7; G-PROTEIN COUPLED RECEPTOR 85-RELATED; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:AEZ50079.1};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 76..99
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 111..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 265..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 15..317
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AEZ50079.1"
FT NON_TER 323
FT /evidence="ECO:0000313|EMBL:AEZ50079.1"
SQ SEQUENCE 323 AA; 36508 MW; C1D6D8FF21DC7022 CRC64;
KLTSLGFIIG VGVVGNLLIS ILLVKDKTLH RAPYYFLLDL CGSDILRSAI CFPFVFTSVK
NGSTWTYGTL TCKVIAFLGV LSCFHTAFML FCISVTRYLA IAHHRFYTKR LTFWTCLAVI
CMVWTLSVAM AFPPVLDVGT YSFIREEDQC TFQHRSFRAN DSLGFMLLLA LILLATQLVY
LKLIFFVHDR RKMKPVQFVP AVSQNWTFHG PGASGQAAAN WLAGFGRGPT PPTLLGIRQN
TNTAGRRRLL VLDEFKTEKR ISRMFYIMTF FFLTLWGPYL VACYWRVFAR GPVVPGGYLT
AAVWMSFAQA GVNPFICIFS NRE
//
