ID H6WFB0_HBV Unreviewed; 394 AA.
AC H6WFB0;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE Flags: Fragment;
GN Name=P {ECO:0000313|EMBL:AEZ65447.1};
OS Hepatitis B virus (HBV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX NCBI_TaxID=10407 {ECO:0000313|EMBL:AEZ65447.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:AEZ65447.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=25GAT {ECO:0000313|EMBL:AEZ65447.1};
RX PubMed=22142487; DOI=10.1016/j.meegid.2011.11.009;
RA Zehender G., Shkjezi R., Ebranati E., Gabanelli E., Abazaj Z., Tanzi E.,
RA Kraja D., Bino S., Ciccozzi M., Galli M.;
RT "Reconstruction of the epidemic history of hepatitis B virus genotype D in
RT Albania.";
RL Infect. Genet. Evol. 12:291-298(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000077};
CC -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC {ECO:0000256|ARBA:ARBA00007994}.
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DR EMBL; JQ244800; AEZ65447.1; -; Genomic_DNA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001462; DNApol_viral_C.
DR InterPro; IPR000201; DNApol_viral_N.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR Pfam; PF00336; DNA_pol_viral_C; 1.
DR Pfam; PF00242; DNA_pol_viral_N; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 117..360
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AEZ65447.1"
FT NON_TER 394
FT /evidence="ECO:0000313|EMBL:AEZ65447.1"
SQ SEQUENCE 394 AA; 44287 MW; FA88FCAC1DC37398 CRC64;
WSIRAGIHPT ARRPFGVEPS GSGHNTNLAS KSASIINQSS VRKAAYPAVS TFEKHSSSGH
AVEFHNFPPN SARSQGERPV FPCWWLQFRN SKPCSDYCLS HIVNLLEDWG PCAEHGEHHI
RIPRTPARVT GGVFLVDKNP HNTAESRLVV DFSQFSRGNH RVSWPKFAVP NLQSLTNLLS
SNLSWLSLDV SAAFYHLPLH PAAMPHLLVG STGLSRYVAR VSSNSRIFNH QRGTMQNLHD
YCSRNLYVSL LLLYQTFGRK LHLYSHPIIL GFRKIPMGVG LSPFLLAQFT SAICSVVRRA
FPHCLAFSYM DDVVLGAKSV QHLESLFTAV TNFLLSLGIH LNPNKTKRWG YSLHFMGYVI
GSYGSLPQDH IIQKIKECFR KLPINRPIDW KVCQ
//
