ID H7BYF1_HUMAN Unreviewed; 734 AA.
AC H7BYF1;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=ATPase family AAA domain containing 2B {ECO:0000313|Ensembl:ENSP00000370412.4};
DE Flags: Fragment;
GN Name=ATAD2B {ECO:0000313|Ensembl:ENSP00000370412.4};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000370412.4, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000370412.4, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2] {ECO:0007829|PubMed:19413330}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [3] {ECO:0007829|PubMed:21406692}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [4] {ECO:0007829|PubMed:23186163}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=23186163;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [5] {ECO:0007829|PubMed:24275569}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [6] {ECO:0000313|Ensembl:ENSP00000370412.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC009242; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC066692; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC079924; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF456640; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR MassIVE; H7BYF1; -.
DR MaxQB; H7BYF1; -.
DR PeptideAtlas; H7BYF1; -.
DR ProteomicsDB; 43597; -.
DR Antibodypedia; 27378; 27 antibodies from 13 providers.
DR Ensembl; ENST00000381024.4; ENSP00000370412.4; ENSG00000119778.15.
DR UCSC; uc061hav.1; human.
DR HGNC; HGNC:29230; ATAD2B.
DR VEuPathDB; HostDB:ENSG00000119778; -.
DR GeneTree; ENSGT00550000074694; -.
DR HOGENOM; CLU_001448_3_1_1; -.
DR ChiTaRS; ATAD2B; human.
DR Proteomes; UP000005640; Chromosome 2.
DR Bgee; ENSG00000119778; Expressed in buccal mucosa cell and 183 other cell types or tissues.
DR ExpressionAtlas; H7BYF1; baseline and differential.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR CDD; cd05528; Bromo_AAA; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR045199; ATAD2-like.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR23069; AAA DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR23069:SF5; ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 2B; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
PE 1: Evidence at protein level;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035};
KW Proteomics identification {ECO:0007829|EPD:H7BYF1,
KW ECO:0007829|MaxQB:H7BYF1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 239..314
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 465..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 583..606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..534
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000370412.4"
SQ SEQUENCE 734 AA; 83993 MW; 78AA4314FD3F3322 CRC64;
XEDENALSIF ETNCHSGSPK KQSSSAAIHK PYLHFTMSPY HQPTSYRPRL LLSGERGSGQ
TSHLAPALLH TLERFSVHRL DLPALYSVSA KTPEESCAQI FREARRTVPS IVYMPHIGDW
WEAVSETVRA TFLTLLQDIP SFSPIFLLST SETMYSELPE EVKCIFRIQY EEVLYIQRPI
EEDRRKFFQE LILNQASMAP PRRKHAALCA MEVLPLALPS PPRQLSESEK SRMEDQEENT
LRELRLFLRD VTKRLATDKR FNIFSKPVSD YLEVIKEPMD LSTVITKIDK HNYLTAKDFL
KDIDLICSNA LEYNPDKDPG DKIIRHRACT LKDTAHAIIA AELDPEFNKL CEEIKEARIK
RGLSVTSEQI NPHSTGARKT ETRVEEAFRH KQRNPMDVWH NSANKCAFRV RRKSRRRSQW
GKGIIKKRKV NNLKKDEEDT KFADYENHTE DRKLLENGEF EVSTDCHEEN GEETGDLSMT
NDESSCDIMD LDQGQRLNNG AGTKENFAST EEESSNESLL VNSSSSLNPE QTSRKETFLK
GNCLNGEAST DSFEGIPVLE CQNGKLEVVS FCDSGDKCSS EQKILLEDQS KEKPETSTEN
HGDDLEKLEA LECSNNEKLE PGSDVEVKDA ELDKEGASKV KKYRKLILEQ AKTTSLELVP
EEPSEPVPPL IVDRERLKKL LDLLVDKSNN LAVDQLERLY SLLSQCIYRH RKDYDKSQLV
EEMERTVHMF ETFL
//
