ID H7BZI8_HUMAN Unreviewed; 173 AA.
AC H7BZI8;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=PAX-interacting protein 1 {ECO:0000256|ARBA:ARBA00023858};
DE AltName: Full=PAX transactivation activation domain-interacting protein {ECO:0000256|ARBA:ARBA00030146};
DE Flags: Fragment;
GN Name=PAXIP1 {ECO:0000313|Ensembl:ENSP00000389849.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000389849.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000389849.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [2] {ECO:0000313|Ensembl:ENSP00000389849.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC093726; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H7BZI8; -.
DR SMR; H7BZI8; -.
DR MassIVE; H7BZI8; -.
DR MaxQB; H7BZI8; -.
DR PeptideAtlas; H7BZI8; -.
DR ProteomicsDB; 43969; -.
DR Antibodypedia; 1874; 149 antibodies from 25 providers.
DR Ensembl; ENST00000419436.1; ENSP00000389849.1; ENSG00000157212.20.
DR UCSC; uc064jof.1; human.
DR HGNC; HGNC:8624; PAXIP1.
DR VEuPathDB; HostDB:ENSG00000157212; -.
DR GeneTree; ENSGT00940000155757; -.
DR HOGENOM; CLU_1551131_0_0_1; -.
DR ChiTaRS; PAXIP1; human.
DR Proteomes; UP000005640; Chromosome 7.
DR Bgee; ENSG00000157212; Expressed in secondary oocyte and 183 other cell types or tissues.
DR ExpressionAtlas; H7BZI8; baseline and differential.
DR GO; GO:0005694; C:chromosome; IEA:UniProt.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProt.
DR CDD; cd17714; BRCT_PAXIP1_rpt1; 1.
DR CDD; cd17710; BRCT_PAXIP1_rpt2; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR PANTHER; PTHR23196; PAX TRANSCRIPTION ACTIVATION DOMAIN INTERACTING PROTEIN; 1.
DR PANTHER; PTHR23196:SF37; PAX-INTERACTING PROTEIN 1; 1.
DR Pfam; PF12738; PTCB-BRCT; 1.
DR SMART; SM00292; BRCT; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR PROSITE; PS50172; BRCT; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:H7BZI8,
KW ECO:0007829|MaxQB:H7BZI8};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 55..141
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 145..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..167
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000389849.1"
FT NON_TER 173
FT /evidence="ECO:0000313|Ensembl:ENSP00000389849.1"
SQ SEQUENCE 173 AA; 19701 MW; 268965F0D5AE36F4 CRC64;
KVPEEMFREV KYYAVGDIDP QVIQLLKAGK AKEVSYNALA SHIISEDGDN PEVGEAREVF
DLPVVKVSSE DRSALWALVT FYGGDCQLTL NKKCTHLIVP EPKGEKYECA LKRASIKIVT
PDWVLDCVSE KTKKDEAFYH PRLIIYEEEE EEEEEEEEVE NEEQDSQNEG STD
//
