ID H7C008_HUMAN Unreviewed; 306 AA.
AC H7C008;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Transmembrane protein 214 {ECO:0000313|Ensembl:ENSP00000392442.1};
DE Flags: Fragment;
GN Name=TMEM214 {ECO:0000313|Ensembl:ENSP00000392442.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000392442.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000392442.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2] {ECO:0007829|PubMed:21269460}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [3] {ECO:0007829|PubMed:25944712}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
RN [4] {ECO:0000313|Ensembl:ENSP00000392442.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Critical mediator, in cooperation with CASP4, of endoplasmic
CC reticulum-stress induced apoptosis. Required or the activation of CASP4
CC following endoplasmic reticulum stress.
CC {ECO:0000256|ARBA:ARBA00024938}.
CC -!- SUBUNIT: Constitutively interacts with CASP4; required for the
CC localization of procaspase 4 to the ER.
CC {ECO:0000256|ARBA:ARBA00011720}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMEM214 family.
CC {ECO:0000256|ARBA:ARBA00007984}.
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DR EMBL; AC013472; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H7C008; -.
DR MassIVE; H7C008; -.
DR MaxQB; H7C008; -.
DR PeptideAtlas; H7C008; -.
DR ProteomicsDB; 44137; -.
DR Antibodypedia; 28071; 138 antibodies from 26 providers.
DR Ensembl; ENST00000444135.5; ENSP00000392442.1; ENSG00000119777.20.
DR UCSC; uc061hjh.1; human.
DR HGNC; HGNC:25983; TMEM214.
DR VEuPathDB; HostDB:ENSG00000119777; -.
DR GeneTree; ENSGT00390000002693; -.
DR HOGENOM; CLU_910710_0_0_1; -.
DR ChiTaRS; TMEM214; human.
DR Proteomes; UP000005640; Chromosome 2.
DR Bgee; ENSG00000119777; Expressed in adenohypophysis and 206 other cell types or tissues.
DR ExpressionAtlas; H7C008; baseline and differential.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR019308; TMEM214.
DR PANTHER; PTHR13448; TRANSMEMBRANE PROTEIN 214; 1.
DR PANTHER; PTHR13448:SF0; TRANSMEMBRANE PROTEIN 214; 1.
DR Pfam; PF10151; TMEM214; 1.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Proteomics identification {ECO:0007829|EPD:H7C008,
KW ECO:0007829|MaxQB:H7C008};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000392442.1"
FT NON_TER 306
FT /evidence="ECO:0000313|Ensembl:ENSP00000392442.1"
SQ SEQUENCE 306 AA; 34200 MW; 1E92005C18C3997B CRC64;
KRQHIQGGCA AWMALLTGRG SPLSTPRLCQ PHAPSSLSLC RAVQLLSSLT ECLTVDPLSA
SVWRQLYPKH LSQSSLLLEH LLSSWEQIPK KVQKSLQETI QSLKLTNQEL LRKGSSNNQD
VVTCDMACKG LLQQVQGPRL PWTRLLLLLL VFAVGFLCHD LRSHSSFQAS LTGRLLRSSG
FLPASQQACA KLYSYSLQGY SWLGETLPLW GSHLLTVVRP SLQLAWAHTN ATVSFLSAHC
ASHLAWFGDS LTSLSQRLQI QLPDSVNQLL RYLRELPLLF HQNVLLPLWH LLLEALAWAQ
EHCHEA
//
