ID H7C0M5_HUMAN Unreviewed; 250 AA.
AC H7C0M5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Collagen type VI alpha 2 chain {ECO:0000313|Ensembl:ENSP00000395751.1};
DE Flags: Fragment;
GN Name=COL6A2 {ECO:0000313|Ensembl:ENSP00000395751.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000395751.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000395751.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10830953; DOI=10.1038/35012518;
RG Chromosome 21 mapping and sequencing consortium;
RA Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT "The DNA sequence of human chromosome 21.";
RL Nature 405:311-319(2000).
RN [2] {ECO:0007829|PubMed:24275569}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [3] {ECO:0000313|Ensembl:ENSP00000395751.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AP001101; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP001467; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP001471; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H7C0M5; -.
DR MassIVE; H7C0M5; -.
DR MaxQB; H7C0M5; -.
DR PeptideAtlas; H7C0M5; -.
DR ProteomicsDB; 44350; -.
DR Antibodypedia; 1646; 276 antibodies from 31 providers.
DR Ensembl; ENST00000413758.1; ENSP00000395751.1; ENSG00000142173.17.
DR UCSC; uc062ayd.1; human.
DR HGNC; HGNC:2212; COL6A2.
DR VEuPathDB; HostDB:ENSG00000142173; -.
DR GeneTree; ENSGT00940000155682; -.
DR HOGENOM; CLU_1113514_0_0_1; -.
DR ChiTaRS; COL6A2; human.
DR Proteomes; UP000005640; Chromosome 21.
DR Bgee; ENSG00000142173; Expressed in stromal cell of endometrium and 179 other cell types or tissues.
DR ExpressionAtlas; H7C0M5; baseline and differential.
DR Gene3D; 1.20.5.320; 6-Phosphogluconate Dehydrogenase, domain 3; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR24023; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24023:SF1108; ENDOSTATIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01391; Collagen; 2.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR00453; VWFADOMAIN.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 1: Evidence at protein level;
KW Collagen {ECO:0000256|ARBA:ARBA00023119};
KW Proteomics identification {ECO:0007829|EPD:H7C0M5,
KW ECO:0007829|MaxQB:H7C0M5};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 172..250
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 1..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..99
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..125
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000395751.1"
FT NON_TER 250
FT /evidence="ECO:0000313|Ensembl:ENSP00000395751.1"
SQ SEQUENCE 250 AA; 25501 MW; 8C05335231B7D8AB CRC64;
GNKGAKGDRG LPGPRGPQGA LGEPGKQGSR GDPGDAGPRG DSGQPGPKGD PGRPGFSYPG
PRGAPGEKGE PGPRGPEGGR GDFGLKGEPG RKGEKGEPAD PGPPGEPGPR GPRGVPGPEG
EPGPPGDPGL TECDVMTYVR ETCGCCGSEV SPVPPDDPAT PPDCEKRCGA LDVVFVIDSS
ESIGYTNFTL EKNFVINVVN RLGAIAKDPK SETGTRVGVV QYSHEGTFEA IQLDDERIDS
LSSFKEAVKN
//
