ID H7C298_HUMAN Unreviewed; 818 AA.
AC H7C298;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Doublecortin domain containing 1 {ECO:0000313|Ensembl:ENSP00000404672.2};
DE Flags: Fragment;
GN Name=DCDC1 {ECO:0000313|Ensembl:ENSP00000404672.2};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000404672.2, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000404672.2, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000404672.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AL133296; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL133349; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL133376; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL135932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL137160; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL137804; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL162614; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF455358; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EPD; H7C298; -.
DR MassIVE; H7C298; -.
DR PeptideAtlas; H7C298; -.
DR ProteomicsDB; 44915; -.
DR Ensembl; ENST00000444572.6; ENSP00000404672.2; ENSG00000170959.15.
DR UCSC; uc001mss.2; human.
DR HGNC; HGNC:20625; DCDC1.
DR VEuPathDB; HostDB:ENSG00000170959; -.
DR GeneTree; ENSGT00940000163628; -.
DR HOGENOM; CLU_011373_0_0_1; -.
DR PhylomeDB; H7C298; -.
DR ChiTaRS; DCDC1; human.
DR Proteomes; UP000005640; Chromosome 11.
DR Bgee; ENSG00000170959; Expressed in oviduct epithelium and 108 other cell types or tissues.
DR ExpressionAtlas; H7C298; baseline and differential.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:1902412; P:regulation of mitotic cytokinesis; IEA:InterPro.
DR CDD; cd17158; DCX3_DCDC5; 1.
DR CDD; cd17159; DCX4_DCDC5; 1.
DR CDD; cd00161; RICIN; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR Gene3D; 3.10.20.230; Doublecortin domain; 1.
DR InterPro; IPR043188; DCDC1.
DR InterPro; IPR003533; Doublecortin_dom.
DR InterPro; IPR036572; Doublecortin_dom_sf.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR PANTHER; PTHR46302; DOUBLECORTIN DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR46302:SF3; DOUBLECORTIN DOMAIN-CONTAINING PROTEIN 1; 1.
DR SMART; SM00537; DCX; 2.
DR SUPFAM; SSF89837; Doublecortin (DC); 3.
DR SUPFAM; SSF50370; Ricin B-like lectins; 1.
DR PROSITE; PS50309; DC; 1.
DR PROSITE; PS50231; RICIN_B_LECTIN; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:H7C298};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 1..40
FT /note="Doublecortin"
FT /evidence="ECO:0000259|PROSITE:PS50309"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000404672.2"
SQ SEQUENCE 818 AA; 92286 MW; E2DF7C206C936549 CRC64;
XCTEILNLPS AARRLYNEKG KEIFALKDLQ RDELVYVSCG ELWINPDLSI AQQKKQIFLR
NLESDIAKIQ IFCSTHKIEA LVLEVQSDIV SGSKLAVHKP VAIFGEEKQV TEPEEKQMQE
DPLTTENASS EILDSHVRAH LRMKACHTLP RYAWQETSHD FDEDDSLPKK TEKGLFENVE
PQKKHSCSPK HSKLHKHCHQ QFEYRDGQII SHAAPQLVLG VQGPNLRSGM EVVLVEKKSD
GSHQRWIHQE DSRTFHLVSN PDLVLAVSMT KTRNEVCGYP VIVQKYKPYN NGAANQKWHY
MKNIKALVAF HSTALDKEIT SANYAGVCTS SVIKEENIDQ PGYCYLSPDG KRKTMLCLAC
GQSMRTEKGL KQLLPGVPFL CISGTKTQKP FLQGPFKVIS VAEVDLSCDK AEKTLSYYQA
RLLSLRMKTC TQAASHSGMA ATHQKAVKII AYKNGDGYRN GKLIVAGTFP MLLTECTEQL
GLARAASKVY TKDGTPIFTL RDLVLWALDE SFLQRDSEKQ KQDAAPVGKE QIIVEKNPRM
KVKNRLFAKS VTSDSLDGID KSLLTLILRN PIAIWVSCGE PFLPPNALQK AEKLEKQNWL
KKDRILADLD TMRHKMRQLK GRRVAACQPA TMVPTKSPVQ PVVVEGGWTE QTQQEIKLME
LIRHTEAHLS EIQEMESKIN FPIATKRIAV KPSNLYKQPN TKRVWIYLNG GRPEDGTYAW
GKTISELLQD CSSRLKMTHP ARALYTPSGE PIQSWDDIER DMVICVSMGH GFKTPKELKQ
LMEIRANYAR IRRQQGPQAT DIVVSPSTKL LSLAHLHN
//
