ID H7C5R5_HUMAN Unreviewed; 316 AA.
AC H7C5R5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Eukaryotic translation initiation factor 2A {ECO:0000256|ARBA:ARBA00013819};
DE Flags: Fragment;
GN Name=EIF2A {ECO:0000313|Ensembl:ENSP00000420611.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000420611.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000420611.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [2] {ECO:0007829|PubMed:21269460}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [3] {ECO:0000313|Ensembl:ENSP00000420611.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Functions in the early steps of protein synthesis of a small
CC number of specific mRNAs. Acts by directing the binding of methionyl-
CC tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it
CC binds methionyl-tRNAi to 40S subunits in a codon-dependent manner,
CC whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a
CC GTP-dependent manner. {ECO:0000256|ARBA:ARBA00003993}.
CC -!- SIMILARITY: Belongs to the WD repeat EIF2A family.
CC {ECO:0000256|ARBA:ARBA00009573}.
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DR EMBL; AC107426; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR MassIVE; H7C5R5; -.
DR MaxQB; H7C5R5; -.
DR PeptideAtlas; H7C5R5; -.
DR ProteomicsDB; 46109; -.
DR Antibodypedia; 33590; 377 antibodies from 35 providers.
DR Ensembl; ENST00000465535.1; ENSP00000420611.1; ENSG00000144895.12.
DR UCSC; uc062pam.1; human.
DR HGNC; HGNC:3254; EIF2A.
DR VEuPathDB; HostDB:ENSG00000144895; -.
DR GeneTree; ENSGT00730000111053; -.
DR HOGENOM; CLU_063472_0_0_1; -.
DR ChiTaRS; EIF2A; human.
DR Proteomes; UP000005640; Chromosome 3.
DR Bgee; ENSG00000144895; Expressed in secondary oocyte and 187 other cell types or tissues.
DR ExpressionAtlas; H7C5R5; baseline and differential.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR011387; TIF2A.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13227; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR PANTHER; PTHR13227:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR Pfam; PF08662; eIF2A; 1.
DR SUPFAM; SSF50960; TolB, C-terminal domain; 1.
PE 1: Evidence at protein level;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Proteomics identification {ECO:0007829|EPD:H7C5R5,
KW ECO:0007829|MaxQB:H7C5R5};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT DOMAIN 2..185
FT /note="Translation initiation factor beta propellor-like"
FT /evidence="ECO:0000259|Pfam:PF08662"
FT REGION 213..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000420611.1"
SQ SEQUENCE 316 AA; 35300 MW; 5FE3546D8949F9A8 CRC64;
XWNKKATAVL VIASTDVDKT GASYYGEQTL HYIATNGESA VVQLPKNGPI YDVVWNSSST
EFCAVYGFMP AKATIFNLKC DPVFDFGTGP RNAAYYSPHG HILVLAGFGN LRGQMEVWDV
KNYKLISKPV ASDSTYFAWC PDGEHILTAT CAPRLRVNNG YKIWHYTGSI LHKYDVPSNA
ELWQVSWQPF LDGIFPAKTI TYQAVPSEVP NEEPKVATAY RPPALRNKPI TNSKLHEEEP
PQNMKPQSGN DKPLSKTALK NQRKHEAKKA AKQKLKAIEQ LKEQAATGKQ LEKNQLEKIQ
KETALLQELE DLELGI
//
