ID H7C6A2_CORGT Unreviewed; 386 AA.
AC H7C6A2;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Cystathionine gamma-synthase {ECO:0000313|EMBL:AAD54070.1};
GN Name=metB {ECO:0000313|EMBL:AAD54070.1};
GN ORFNames=APT58_11870 {ECO:0000313|EMBL:AMA00884.1};
OS Corynebacterium glutamicum (Brevibacterium saccharolyticum).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=1718 {ECO:0000313|EMBL:AAD54070.1};
RN [1] {ECO:0000313|EMBL:AAD54070.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ASO19 {ECO:0000313|EMBL:AAD54070.1};
RX PubMed=10420990;
RA Hwang B.J., Kim Y., Kim H.B., Hwang H.J., Kim J.H., Lee H.S.;
RT "Analysis of Corynebacterium glutamicum methionine biosynthetic pathway:
RT isolation and analysis of metB encoding cystathionine gamma-synthase.";
RL Mol. Cells 9:300-308(1999).
RN [2] {ECO:0000313|EMBL:AAD54070.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ASO19 {ECO:0000313|EMBL:AAD54070.1};
RA Hwang B.-J., Lee H.-S.;
RL Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AMA00884.1, ECO:0000313|Proteomes:UP000069326}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=USDA-ARS-USMARC-56828 {ECO:0000313|EMBL:AMA00884.1,
RC ECO:0000313|Proteomes:UP000069326};
RA Harhay G.P., Harhay D.M., Smith T.P.L., Bono J.L., Heaton M.P.,
RA Clawson M.L., Chitko-Mckown C.G., Capik S.F., DeDonder K.D., Apley M.D.,
RA Lubbers B.V., White B.J., Larson R.L.;
RT "Annotation of Corynebacterium glutamicum USDA-ARS-USMARC-56828.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU362118};
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC {ECO:0000256|ARBA:ARBA00009077, ECO:0000256|RuleBase:RU362118}.
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DR EMBL; AF126953; AAD54070.1; -; Genomic_DNA.
DR EMBL; CP013991; AMA00884.1; -; Genomic_DNA.
DR PIR; T47234; T47234.
DR RefSeq; WP_011015127.1; NZ_JOLA01000016.1.
DR KEGG; cgj:AR0_11720; -.
DR KEGG; cgq:CGLAR1_11570; -.
DR PATRIC; fig|1718.43.peg.2395; -.
DR OMA; YKQDGVG; -.
DR BRENDA; 2.5.1.48; 960.
DR Proteomes; UP000069326; Chromosome.
DR GO; GO:0016846; F:carbon-sulfur lyase activity; IEA:UniProt.
DR GO; GO:0003962; F:cystathionine gamma-synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0102028; F:cystathionine gamma-synthase activity (acts on O-phosphohomoserine); IEA:UniProtKB-EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR CDD; cd00614; CGS_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR11808:SF92; CYSTATHIONINE GAMMA-SYNTHASE; 1.
DR PANTHER; PTHR11808; TRANS-SULFURATION ENZYME FAMILY MEMBER; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR PIRSF; PIRSF001434; CGS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW Methionine biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR001434-2}.
FT MOD_RES 204
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ SEQUENCE 386 AA; 41658 MW; 72EBB2B34275296A CRC64;
MSFDPNTQGF STASIHAGYE PDDYYGSINT PIYASTTFAQ NAPNELRKGY EYTRVGNPTI
VALEQTVAAL EGAKYGRAFS SGMAATDILF RIILKPGDHI VLGNDAYGGT YRLIDTVFTA
WGVEYTVVDT SVVEEVKAAI KDNTKLIWVE TPTNPALGIT DIEAVAKLTE GTNAKLVVDN
TFASPYLQQP LKLGAHAVLH STTKYIGGHS DVVGGLVVTN DQEMDEELLF MQGGIGPIPS
VFDAYLTARG LKTLAVRMDR HCDNAEKIAE FLDSRPEVST VLYPGLKNHP GHEVAAKQMK
RFGGMISVRF AGGEEAAKKF CTSTKLICLA ESLGGVESLL EHPATMTHQS AAGSQLEVPR
DLVRISIGIE DIEDLLADVE QALNNL
//
