ID H7C831_XENLA Unreviewed; 298 AA.
AC H7C831;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 {ECO:0000256|ARBA:ARBA00015644};
DE EC=2.4.99.20 {ECO:0000256|ARBA:ARBA00012600};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
DE AltName: Full=2'-phospho-ADP-ribosyl cyclase {ECO:0000256|ARBA:ARBA00031840};
DE AltName: Full=2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase {ECO:0000256|ARBA:ARBA00030418};
DE AltName: Full=2'-phospho-cyclic-ADP-ribose transferase {ECO:0000256|ARBA:ARBA00029787};
DE AltName: Full=ADP-ribosyl cyclase 1 {ECO:0000256|ARBA:ARBA00031355};
DE AltName: Full=Cyclic ADP-ribose hydrolase 1 {ECO:0000256|ARBA:ARBA00030272};
GN Name=CD38 {ECO:0000313|EMBL:BAL72804.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:BAL72804.1};
RN [1] {ECO:0000313|EMBL:BAL72804.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Liver {ECO:0000313|EMBL:BAL72803.1};
RX PubMed=22422046; DOI=10.1007/s11010-012-1284-0;
RA Ikeda T., Takasawa S., Noguchi N., Nata K., Yamauchi A., Takahashi I.,
RA Yoshikawa T., Sugawara A., Yonekura H., Okamoto H.;
RT "Identification of a major enzyme for the synthesis and hydrolysis of
RT cyclic ADP-ribose in amphibian cells and evolutional conservation of the
RT enzyme from human to invertebrate.";
RL Mol. Cell. Biochem. 366:69-80(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000457};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the ADP-ribosyl cyclase family.
CC {ECO:0000256|ARBA:ARBA00005406}.
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DR EMBL; AB194899; BAL72803.1; -; mRNA.
DR EMBL; AB194900; BAL72804.1; -; Genomic_DNA.
DR RefSeq; NP_001244280.1; NM_001257351.1.
DR AlphaFoldDB; H7C831; -.
DR SMR; H7C831; -.
DR GeneID; 100873156; -.
DR CTD; 100873156; -.
DR BRENDA; 3.2.2.6; 6725.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0050135; F:NAD(P)+ nucleosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0061809; F:NAD+ nucleotidase, cyclic ADP-ribose generating; IEA:UniProtKB-EC.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR CDD; cd04759; Rib_hydrolase; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR003193; ADP-ribosyl_cyclase.
DR PANTHER; PTHR10912; ADP-RIBOSYL CYCLASE; 1.
DR PANTHER; PTHR10912:SF5; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE 1; 1.
DR Pfam; PF02267; Rib_hydrolayse; 1.
DR SUPFAM; SSF52309; N-(deoxy)ribosyltransferase-like; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 15..38
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 298 AA; 33099 MW; 98DA495AE40F28A1 CRC64;
MATRSNSRCS LRVGVIGIIV TICVIILIIS LIAAYTAIKR KEDTHIWKGQ GTTQNLQDIV
LGRCYNYVTM NPGIGKKNCD AIWQALTGAV YKKNPCNITQ EDYKPLADLA LQTIPCNKTL
LWSKTNSLVH RYTKASQDFL TLEDTFLGSM FDSLMWCGMS YSSEMNYDSC PAWNECDNNA
ISAFWKMASA TFAKASCGVV NVMLNGSADG GVARKESILR TVEVPSMNVN AVSEVRLWII
DDLEGPDKNS CDTESAVELK DYIEQHKLPF SCIDNYRPVQ LLQCIETPDL PACKLCKS
//
