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Database: UniProt
Entry: H7EPG4_9SPIO
LinkDB: H7EPG4_9SPIO
Original site: H7EPG4_9SPIO 
ID   H7EPG4_9SPIO            Unreviewed;       580 AA.
AC   H7EPG4;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   16-MAY-2012, sequence version 1.
DT   05-JUL-2017, entry version 36.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=TresaDRAFT_0459 {ECO:0000313|EMBL:EIC00365.1};
OS   Treponema saccharophilum DSM 2985.
OC   Bacteria; Spirochaetes; Spirochaetales; Spirochaetaceae; Treponema.
OX   NCBI_TaxID=907348 {ECO:0000313|EMBL:EIC00365.1, ECO:0000313|Proteomes:UP000003571};
RN   [1] {ECO:0000313|EMBL:EIC00365.1, ECO:0000313|Proteomes:UP000003571}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 2985 {ECO:0000313|EMBL:EIC00365.1,
RC   ECO:0000313|Proteomes:UP000003571};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Peters L., Kyrpides N.,
RA   Mavromatis K., Ivanova N., Markowitz V., Cheng J.-F., Hugenholtz P.,
RA   Woyke T., Wu D., Gronow S., Wellnitz S., Brambilla E., Klenk H.-P.,
RA   Eisen J.A.;
RT   "The draft genome of Treponema saccharophilum DSM 2985.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EIC00365.1}.
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DR   EMBL; AGRW01000055; EIC00365.1; -; Genomic_DNA.
DR   EnsemblBacteria; EIC00365; EIC00365; TresaDRAFT_0459.
DR   PATRIC; fig|907348.3.peg.2864; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000003571; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000003571};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003571}.
FT   DOMAIN      270    402       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      485    555       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     278    285       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   580 AA;  66287 MW;  35DF2FCADF1EF3FB CRC64;
     MLSGAGGFFL GRDGRERSKL FGFWGRIGGM SEQIYKDFFE EALNQIREEY AANGREDYFK
     VWFNLGYVED TLDTITVSIP SEAMWKLMKK NGSAEEIQNK IDELAGQKIT LIPAAKRAVK
     SEEMPQSQQP AQAQKSPQNE EEPKLSNQER FNNVNDWLTQ EIERRKKIED GDAGKAAAEE
     EAEPTQAGDD YQSYIAQELQ KQNLPQKTSG YDEEYQKFLS QEVQKLNTKT SLTNHPMLRD
     DYTFDNFIPG ANSQYAYHAS QRAAENPGRE YNPMLIYGGV GLGKTHLMQA IGNYIFAHNN
     DARICYISAE SFTNEFTYSL QTKTVDKFKK KYRSLDVLLL DDIQFFEGKE ATQEELFHTF
     NEIYDRKGQL VFTCDRPITE IQGITDRLRT RFSRGLNIDL QPPEYETRRA ILEQKMNSQG
     SGKKIPSDVI DYIAQNIQSN VRDLESCMMK MLGYCDLVGQ ELTIDIAREL LKDKIDESAP
     AGAVTVEAIQ QAVAKYYGIK QADIVGKKKN KQYVLPRQIA IYITRDMLRE YSLKDIGYEF
     GGRDHTTILS AIEKITTQMK INPTTEAVVK QLEKDAHDFV
//
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