ID H7FXC6_9LACO Unreviewed; 760 AA.
AC H7FXC6;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=DNA translocase FtsK {ECO:0000256|ARBA:ARBA00020887};
GN ORFNames=SMXD51_03903 {ECO:0000313|EMBL:EIA33113.1};
OS Ligilactobacillus salivarius SMXD51.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Ligilactobacillus.
OX NCBI_TaxID=1108963 {ECO:0000313|EMBL:EIA33113.1, ECO:0000313|Proteomes:UP000003657};
RN [1] {ECO:0000313|EMBL:EIA33113.1, ECO:0000313|Proteomes:UP000003657}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SMXD51 {ECO:0000313|EMBL:EIA33113.1,
RC ECO:0000313|Proteomes:UP000003657};
RX PubMed=22582370; DOI=10.1128/JB.00344-12;
RA Kergourlay G., Messaoudi S., Dousset X., Prevost H.;
RT "Genome Sequence of Lactobacillus salivarius SMXD51, a Potential Probiotic
RT Strain Isolated from Chicken Cecum, Showing Anti-Campylobacter Activity.";
RL J. Bacteriol. 194:3008-3009(2012).
CC -!- SUBUNIT: Homohexamer. Forms a ring that surrounds DNA.
CC {ECO:0000256|ARBA:ARBA00025923}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FtsK/SpoIIIE/SftA family.
CC {ECO:0000256|ARBA:ARBA00006474}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EIA33113.1}.
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DR EMBL; AICL01000003; EIA33113.1; -; Genomic_DNA.
DR RefSeq; WP_003709828.1; NZ_AICL01000003.1.
DR AlphaFoldDB; H7FXC6; -.
DR PATRIC; fig|1108963.3.peg.1478; -.
DR HOGENOM; CLU_001981_12_4_9; -.
DR Proteomes; UP000003657; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR CDD; cd01127; TrwB_TraG_TraD_VirD4; 1.
DR Gene3D; 3.30.980.40; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041027; FtsK_alpha.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR018541; Ftsk_gamma.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22683:SF42; DNA TRANSLOCASE SFTA; 1.
DR PANTHER; PTHR22683; SPORULATION PROTEIN RELATED; 1.
DR Pfam; PF17854; FtsK_alpha; 1.
DR Pfam; PF09397; FtsK_gamma; 1.
DR Pfam; PF01580; FtsK_SpoIIIE; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00843; Ftsk_gamma; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50901; FTSK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Chromosome partition {ECO:0000256|ARBA:ARBA00022829};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00289}.
FT DOMAIN 426..618
FT /note="FtsK"
FT /evidence="ECO:0000259|PROSITE:PS50901"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 129..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..171
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..214
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 443..450
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
SQ SEQUENCE 760 AA; 85849 MW; 204F612ED6934120 CRC64;
MEHYDGPAFF RRQGRSSNID ENSAKKSSNV SSTSSFKKAS HKFEGRNIRR QRAFVRTSTT
LDSYRTRSFR PTYVPPSSIR FTNKNDKEKY SKLVAKLRLK FNNLWLFTDD FQESKDIVDD
NIFEENNLQQ IEDKNELPED ELETPADSKL TEEINDDNAD DNIKVNKEQE ISEPTDDEEN
QGNEETEDIN SNEIEVSEDS MEQNDIDTIS SEESDDNSMD TVIPYETARN YHHEEVEETV
ELKQQDNAPK KKALDRSLDE IMRQEKNDMQ SHLSLFNQSQ KGDNKENLMY KFPEMSLLPD
PVINDEDEMD EWVLQEVDIL NETLEAFHVK AEVTNWTIGP TVTQFEVTLN RGVKVNKITN
LTDDLKLALA AKDIRIEAPI PGKRSVGIEI PNKKSRPVML SEVLNSKVFK EATSPLTVAL
GVDLFGQPQV TNIAKMPHGL IAGATGSGKS VFINSMLVSL LYKATPAELK LLLIDPKAVE
MAPYHDIPHL LAPVVSDPQA ATASLKWAVN EMEERFERLA AAGAKNIESY NEKAEENGDY
GLKMPYIVIV IDELADLMMV ASSEVQDYII RITQKARAAG IHMIIATQRP SVDVITGVIK
SNIPTRIAFM VSSQVDSRTI LDSSGAERLL GRGDMLYLGN GESQARRIQG TYVEDEIEKI
TDFIREQGTP TYAFNPDKLK VIETQTENED DLMPEILEYI VNEDGISISK LQRVFSIGYN
RAAKIIDDLE SKQYISSAKG SKPRDVYLTP EKLEKMKGTN
//
