ID H7GFK7_9DEIN Unreviewed; 457 AA.
AC H7GFK7;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=Coproporphyrinogen III oxidase {ECO:0000256|RuleBase:RU364052};
DE EC=1.3.3.15 {ECO:0000256|RuleBase:RU364052};
GN ORFNames=RLTM_04571 {ECO:0000313|EMBL:EIA39519.1};
OS Thermus parvatiensis.
OC Bacteria; Deinococcota; Deinococci; Thermales; Thermaceae; Thermus.
OX NCBI_TaxID=456163 {ECO:0000313|EMBL:EIA39519.1, ECO:0000313|Proteomes:UP000053186};
RN [1] {ECO:0000313|EMBL:EIA39519.1, ECO:0000313|Proteomes:UP000053186}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RL {ECO:0000313|EMBL:EIA39519.1,
RC ECO:0000313|Proteomes:UP000053186};
RX PubMed=22689228; DOI=10.1128/JB.00604-12;
RA Dwivedi V., Sangwan N., Nigam A., Garg N., Niharika N., Khurana P.,
RA Khurana J.P., Lal R.;
RT "Draft genome sequence of Thermus sp. strain RL, isolated from a hot water
RT spring located atop the Himalayan ranges at Manikaran, India.";
RL J. Bacteriol. 194:3534-3534(2012).
CC -!- FUNCTION: Involved in coproporphyrin-dependent heme b biosynthesis.
CC Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin
CC III. {ECO:0000256|RuleBase:RU364052}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=coproporphyrinogen III + 3 O2 = coproporphyrin III + 3 H2O2;
CC Xref=Rhea:RHEA:43436, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240,
CC ChEBI:CHEBI:57309, ChEBI:CHEBI:131725; EC=1.3.3.15;
CC Evidence={ECO:0000256|RuleBase:RU364052};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|RuleBase:RU364052};
CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoheme
CC biosynthesis. {ECO:0000256|RuleBase:RU364052}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU364052}.
CC -!- SIMILARITY: Belongs to the protoporphyrinogen/coproporphyrinogen
CC oxidase family. Coproporphyrinogen III oxidase subfamily.
CC {ECO:0000256|RuleBase:RU364052}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EIA39519.1}.
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DR EMBL; AIJQ01000004; EIA39519.1; -; Genomic_DNA.
DR RefSeq; WP_008631961.1; NZ_AIJQ01000004.1.
DR PATRIC; fig|456163.3.peg.900; -.
DR UniPathway; UPA00252; -.
DR Proteomes; UP000053186; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004729; F:oxygen-dependent protoporphyrinogen oxidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006783; P:heme biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 1.10.3110.10; protoporphyrinogen ix oxidase, domain 3; 1.
DR InterPro; IPR002937; Amino_oxidase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR004572; Protoporphyrinogen_oxidase.
DR NCBIfam; TIGR00562; proto_IX_ox; 1.
DR PANTHER; PTHR42923; PROTOPORPHYRINOGEN OXIDASE; 1.
DR PANTHER; PTHR42923:SF3; PROTOPORPHYRINOGEN OXIDASE; 1.
DR Pfam; PF01593; Amino_oxidase; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU364052};
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|RuleBase:RU364052};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW ECO:0000256|RuleBase:RU364052};
KW Heme biosynthesis {ECO:0000256|ARBA:ARBA00023133,
KW ECO:0000256|RuleBase:RU364052};
KW Oxidoreductase {ECO:0000256|RuleBase:RU364052}.
FT DOMAIN 14..444
FT /note="Amine oxidase"
FT /evidence="ECO:0000259|Pfam:PF01593"
SQ SEQUENCE 457 AA; 49266 MW; BE94461BA3678617 CRC64;
MAEVGVAVVG GGWAGLXAAL XLKEAGXDFL LLEASLRLGG KVRTARQEGF LVEGGPDASV
RYNKEVLELA QAFGLEPIGT LPEKPAAYIL YRGKRHPLPE GLLQVVPGDL KALARTPLLS
LPGKLRALYD LFLPRGAKED ETLREFVERR LGPEVYRALV APLAGGVYGG EPDDLSMRAA
FPQLWELEGR HRSLLLGAMR VRKGRGSREG GSLFFSFAEG LQALTRRMAE ALGERVLRGT
PVLGLEPARG RWRLHTPKGA LLAEAVVLAI PAPQAAGLLR PFLPEATALL KGIPHTPAAT
VSLAFPGALP VEGHGLLVAK GEGLRARGFT WTHRKWPGRA PEGFSLVRAY FSGEAARLSE
EALIRLALED LARLLPGLPR VHRAWAFRFP EGMPAYRVGH LDRVERLEMA LVKAPGLFLA
GNYLQGVGLP EVVRSGRRAA QRALAHLSLG EAHGASR
//