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Database: UniProt
Entry: H8ESD6_CAEEL
LinkDB: H8ESD6_CAEEL
Original site: H8ESD6_CAEEL 
ID   H8ESD6_CAEEL            Unreviewed;      1146 AA.
AC   H8ESD6;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   16-MAY-2012, sequence version 1.
DT   31-JAN-2018, entry version 54.
DE   SubName: Full=SLOwpoke potassium channel family {ECO:0000313|EMBL:CCG28223.1};
GN   Name=slo-1 {ECO:0000313|EMBL:CCG28223.1,
GN   ECO:0000313|WormBase:Y51A2D.19m};
GN   ORFNames=CELE_Y51A2D.19 {ECO:0000313|EMBL:CCG28223.1}, Y51A2D.19
GN   {ECO:0000313|WormBase:Y51A2D.19m};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:CCG28223.1, ECO:0000313|Proteomes:UP000001940};
RN   [1] {ECO:0000313|EMBL:CCG28223.1, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CCG28223.1,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=https://doi.org/10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SIMILARITY: Belongs to the potassium channel family.
CC       {ECO:0000256|SAAS:SAAS00692852}.
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DR   EMBL; BX284605; CCG28223.1; -; Genomic_DNA.
DR   RefSeq; NP_001256801.1; NM_001269872.1.
DR   UniGene; Cel.7073; -.
DR   ProteinModelPortal; H8ESD6; -.
DR   SMR; H8ESD6; -.
DR   EnsemblMetazoa; Y51A2D.19m; Y51A2D.19m; WBGene00004830.
DR   GeneID; 180203; -.
DR   KEGG; cel:CELE_Y51A2D.19; -.
DR   CTD; 180203; -.
DR   WormBase; Y51A2D.19m; CE47416; WBGene00004830; slo-1.
DR   eggNOG; KOG1420; Eukaryota.
DR   eggNOG; ENOG410YUX1; LUCA.
DR   GeneTree; ENSGT00530000063026; -.
DR   KO; K04936; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00004830; -.
DR   ExpressionAtlas; H8ESD6; baseline and differential.
DR   GO; GO:0031430; C:M band; IDA:WormBase.
DR   GO; GO:0055120; C:striated muscle dense body; IDA:WormBase.
DR   GO; GO:0045202; C:synapse; IDA:WormBase.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR   GO; GO:0015269; F:calcium-activated potassium channel activity; IDA:WormBase.
DR   GO; GO:0060072; F:large conductance calcium-activated potassium channel activity; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IDA:WormBase.
DR   GO; GO:0048149; P:behavioral response to ethanol; IMP:WormBase.
DR   GO; GO:0040011; P:locomotion; IGI:WormBase.
DR   GO; GO:0050804; P:modulation of chemical synaptic transmission; IGI:WormBase.
DR   GO; GO:0043050; P:pharyngeal pumping; IMP:WormBase.
DR   GO; GO:0006813; P:potassium ion transport; IDA:WormBase.
DR   GO; GO:0046928; P:regulation of neurotransmitter secretion; IMP:WormBase.
DR   GO; GO:0042493; P:response to drug; IMP:WormBase.
DR   GO; GO:0045214; P:sarcomere organization; IGI:WormBase.
DR   InterPro; IPR024939; Ca-act_K_channel_Slo-1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003929; K_chnl_BK_asu.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR028325; VG_K_chnl.
DR   PANTHER; PTHR10027:SF33; PTHR10027:SF33; 1.
DR   Pfam; PF03493; BK_channel_a; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR00169; KCHANNEL.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001940};
KW   Ion channel {ECO:0000256|SAAS:SAAS00417203,
KW   ECO:0000313|EMBL:CCG28223.1};
KW   Ion transport {ECO:0000256|SAAS:SAAS00417186};
KW   Membrane {ECO:0000256|SAAS:SAAS00788393, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00417282};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00417246};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00417240};
KW   Proteomics identification {ECO:0000213|EPD:H8ESD6,
KW   ECO:0000213|PeptideAtlas:H8ESD6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00793138,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00789957,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00417268}.
FT   TRANSMEM     48     69       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    155    173       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    198    214       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    226    243       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    282    301       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    321    339       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    346    363       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      158    371       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   1146 AA;  130490 MW;  5FD43F988B35EB7D CRC64;
     MGEIYSPSQS KGFNQPYGYP MNCNLSRVFM EMTEEDRKCL EERKYWCFLL SSITTFCASM
     ILVVIWRVVT HLCCQRREKE FVEPIPAPEA VQINMNGSKH APSETDPFLK QQEEKHLGWM
     TEDSLAMQLY RSIRDRRAKD WAGELISGQS LTGRFLVLLV FILSIGSLII YFYDASFQNF
     QVETCIPWQD SPSQQIDLGF NIFFLVYFFI RFIAASDKVW FLLEMYSWID FFTIPPSFVA
     IYLQRNWLGF RFLRALRLMT VPDILQYLNI LKTSSSIRLT QLVTIFVAVC LTGAGLVHLL
     ENSGDFFKGF INPHRITYAD SVYFVLVTMS TVGYGDIYCT TLCGRLFMIF FILFGLAMFA
     SYVPEIADLI GNRQKYGGEY KGEHGKKHIV VCGHITYDSV SHFLQDFLHE DRDDVDVEVV
     FLHRVVPDLE LEGLFKRHFT KVEFFTGTVM DSLDLSRVKI GDADACLVLA NKYSTNPDAE
     DAANIMRVIS IKNYSSDIRV IVQLMQYHNK AYLLNIPSWD WKRGDDVICL AELKLGFIAQ
     SCLAPGFSTM MANLFAMRSF KTSQTTPDWL NLYLCGAGME MYTDTLSHSF VGMTFPEAVD
     LLFNRLGLLL LAIELKDEEN KECNIAINPG PHIVIQPQTQ GFFIAQSADE VKRAFFWCKQ
     CHDDIKDVSL IKKCKCKNLA LFRRNTKHST AARDYSDFDA LFYQNDARAT DVLQQFQPQA
     PAGPMGHLGQ QVQLRMINQQ RPSSGGRRNS MSIPPDGRGV DFSKDFEQQF QDMKYDSTGM
     FHWCPSRNLE DCVLERHQAA MTVLNGHVVV CLFADQDSPL IGLRNFIMPL RSSNFHYHEL
     KHVVIVGDLE YLRKEWKTLY NLPKISILNG SPLSRADLRA VNINLCDMCV IISARVPNTE
     DTTLADKEAI LASLNIKAMQ FDDTLGFFPM RHQTGDRSPL GSPISMQKKG AKFGTNVPMI
     TELVNDSNVQ FLDQDDDDDP DTELYLTQPF ACGTAFAISV LDSLMSTTYF NDSALTLIRT
     LVTGGATPEL ELILAEGAGL RGGYSTPETL SNRDRCRIAQ ISLQDNPYDG VVHNTTYGAM
     FTIALRRYGQ LCIGLYRLHD QDNPDSMKRY VITNPPAELR IKNTDYVYVL EQFDPGLEYE
     PGKRHF
//
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