ID H8GPC2_METAL Unreviewed; 342 AA.
AC H8GPC2;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=Fido domain-containing protein {ECO:0000259|PROSITE:PS51459};
GN ORFNames=Metal_3194 {ECO:0000313|EMBL:EIC30868.1};
OS Methylomicrobium album BG8.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Methylococcales;
OC Methylococcaceae; Methylomicrobium.
OX NCBI_TaxID=686340 {ECO:0000313|EMBL:EIC30868.1, ECO:0000313|Proteomes:UP000005090};
RN [1] {ECO:0000313|EMBL:EIC30868.1, ECO:0000313|Proteomes:UP000005090}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BG8 {ECO:0000313|EMBL:EIC30868.1,
RC ECO:0000313|Proteomes:UP000005090};
RX PubMed=23580712;
RA Kits K.D., Kalyuzhnaya M.G., Klotz M.G., Jetten M.S., Op den Camp H.J.,
RA Vuilleumier S., Bringel F., Dispirito A.A., Murrell J.C., Bruce D.,
RA Cheng J.F., Copeland A., Goodwin L., Hauser L., Lajus A., Land M.L.,
RA Lapidus A., Lucas S., Medigue C., Pitluck S., Woyke T., Zeytun A.,
RA Stein L.Y.;
RT "Genome Sequence of the Obligate Gammaproteobacterial Methanotroph
RT Methylomicrobium album Strain BG8.";
RL Genome Announc. 1:E0017013-E0017013(2013).
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DR EMBL; CM001475; EIC30868.1; -; Genomic_DNA.
DR RefSeq; WP_005373779.1; NZ_CM001475.1.
DR AlphaFoldDB; H8GPC2; -.
DR STRING; 686340.Metal_3194; -.
DR eggNOG; COG1522; Bacteria.
DR eggNOG; COG3177; Bacteria.
DR HOGENOM; CLU_047250_0_0_6; -.
DR Proteomes; UP000005090; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3290.10; Fido-like domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR003812; Fido.
DR InterPro; IPR036597; Fido-like_dom_sf.
DR InterPro; IPR040198; Fido_containing.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR13504; FIDO DOMAIN-CONTAINING PROTEIN DDB_G0283145; 1.
DR PANTHER; PTHR13504:SF38; PROTEIN ADENYLYLTRANSFERASE AQ_AA38-RELATED; 1.
DR Pfam; PF02661; Fic; 1.
DR Pfam; PF13412; HTH_24; 1.
DR SUPFAM; SSF140931; Fic-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51459; FIDO; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR640198-2};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR640198-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000005090}.
FT DOMAIN 100..242
FT /note="Fido"
FT /evidence="ECO:0000259|PROSITE:PS51459"
FT ACT_SITE 179
FT /evidence="ECO:0000256|PIRSR:PIRSR640198-1"
FT BINDING 130..138
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR640198-2"
FT BINDING 183..190
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR640198-2"
FT BINDING 220..221
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR640198-2"
FT SITE 56
FT /note="Important for autoinhibition of adenylyltransferase
FT activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR640198-3"
SQ SEQUENCE 342 AA; 38630 MW; 2D2F68C705E91947 CRC64;
MPAYQPPFQL THRMTAQMSR ISELLGEWNA INRNTLVPQL RRGNRIRSLH ASLAIEQNTL
TLEQVTAVLD GRIVLGSPRE IQEVRNAFAA YEAMERWLPH RAEDVLAAHA LMMAALVDDA
GRWRRGSVGV MAGDKLVHMA PPARRVPDLM HDLLHWLETT DAHPLIASTA FHYEFEFIHP
FSDGNGRMGR LWQTLILSRW QPMLAYLPVE TVIKRRQQEY YDQLGMADAK ADCSGFIEFL
LDAIETGLRD AIQIENAEKT PVETPVETPV EKSAKTPQRI LALLRQQPEL TLADIAQAIG
RSPRAVERAA AKLQTEGKLC YHGPKKGGRW MVLDDDKAKG RR
//
