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Database: UniProt
Entry: H8GQ38_METAL
LinkDB: H8GQ38_METAL
Original site: H8GQ38_METAL 
ID   H8GQ38_METAL            Unreviewed;       275 AA.
AC   H8GQ38;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   16-MAY-2012, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   RecName: Full=Large ribosomal subunit protein uL2 {ECO:0000256|HAMAP-Rule:MF_01320};
GN   Name=rplB {ECO:0000256|HAMAP-Rule:MF_01320};
GN   ORFNames=Metal_3310 {ECO:0000313|EMBL:EIC30978.1};
OS   Methylomicrobium album BG8.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Methylococcales;
OC   Methylococcaceae; Methylomicrobium.
OX   NCBI_TaxID=686340 {ECO:0000313|EMBL:EIC30978.1, ECO:0000313|Proteomes:UP000005090};
RN   [1] {ECO:0000313|EMBL:EIC30978.1, ECO:0000313|Proteomes:UP000005090}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BG8 {ECO:0000313|EMBL:EIC30978.1,
RC   ECO:0000313|Proteomes:UP000005090};
RX   PubMed=23580712;
RA   Kits K.D., Kalyuzhnaya M.G., Klotz M.G., Jetten M.S., Op den Camp H.J.,
RA   Vuilleumier S., Bringel F., Dispirito A.A., Murrell J.C., Bruce D.,
RA   Cheng J.F., Copeland A., Goodwin L., Hauser L., Lajus A., Land M.L.,
RA   Lapidus A., Lucas S., Medigue C., Pitluck S., Woyke T., Zeytun A.,
RA   Stein L.Y.;
RT   "Genome Sequence of the Obligate Gammaproteobacterial Methanotroph
RT   Methylomicrobium album Strain BG8.";
RL   Genome Announc. 1:E0017013-E0017013(2013).
CC   -!- FUNCTION: One of the primary rRNA binding proteins. Required for
CC       association of the 30S and 50S subunits to form the 70S ribosome, for
CC       tRNA binding and peptide bond formation. It has been suggested to have
CC       peptidyltransferase activity; this is somewhat controversial. Makes
CC       several contacts with the 16S rRNA in the 70S ribosome.
CC       {ECO:0000256|HAMAP-Rule:MF_01320}.
CC   -!- SUBUNIT: Part of the 50S ribosomal subunit. Forms a bridge to the 30S
CC       subunit in the 70S ribosome. {ECO:0000256|HAMAP-Rule:MF_01320}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL2 family.
CC       {ECO:0000256|ARBA:ARBA00005636, ECO:0000256|HAMAP-Rule:MF_01320}.
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DR   EMBL; CM001475; EIC30978.1; -; Genomic_DNA.
DR   RefSeq; WP_005373959.1; NZ_CM001475.1.
DR   AlphaFoldDB; H8GQ38; -.
DR   STRING; 686340.Metal_3310; -.
DR   eggNOG; COG0090; Bacteria.
DR   HOGENOM; CLU_036235_2_1_6; -.
DR   Proteomes; UP000005090; Chromosome.
DR   GO; GO:0015934; C:large ribosomal subunit; IEA:InterPro.
DR   GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0016740; F:transferase activity; IEA:InterPro.
DR   GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.30.30.30; -; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   Gene3D; 4.10.950.10; Ribosomal protein L2, domain 3; 1.
DR   HAMAP; MF_01320_B; Ribosomal_L2_B; 1.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR014722; Rib_uL2_dom2.
DR   InterPro; IPR002171; Ribosomal_uL2.
DR   InterPro; IPR005880; Ribosomal_uL2_bac/org-type.
DR   InterPro; IPR022669; Ribosomal_uL2_C.
DR   InterPro; IPR022671; Ribosomal_uL2_CS.
DR   InterPro; IPR014726; Ribosomal_uL2_dom3.
DR   InterPro; IPR022666; Ribosomal_uL2_RNA-bd_dom.
DR   InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR   NCBIfam; TIGR01171; rplB_bact; 1.
DR   PANTHER; PTHR13691:SF5; 39S RIBOSOMAL PROTEIN L2, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR13691; RIBOSOMAL PROTEIN L2; 1.
DR   Pfam; PF00181; Ribosomal_L2; 1.
DR   Pfam; PF03947; Ribosomal_L2_C; 1.
DR   PIRSF; PIRSF002158; Ribosomal_L2; 1.
DR   SMART; SM01383; Ribosomal_L2; 1.
DR   SMART; SM01382; Ribosomal_L2_C; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   SUPFAM; SSF50104; Translation proteins SH3-like domain; 1.
DR   PROSITE; PS00467; RIBOSOMAL_L2; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005090};
KW   Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274, ECO:0000256|HAMAP-
KW   Rule:MF_01320};
KW   Ribosomal protein {ECO:0000256|ARBA:ARBA00022980, ECO:0000256|HAMAP-
KW   Rule:MF_01320}; RNA-binding {ECO:0000256|HAMAP-Rule:MF_01320};
KW   rRNA-binding {ECO:0000256|HAMAP-Rule:MF_01320}.
FT   DOMAIN          124..252
FT                   /note="Large ribosomal subunit protein uL2 C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01382"
FT   REGION          28..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          223..258
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   275 AA;  30099 MW;  26E92598A5E8E2CB CRC64;
     MAIVKSKPTS PGSRFVVRIK SDDLHKGKPY APLLDKNSKT GGRNNQGRIT TRHVGGGHKQ
     HYRIIDFKRN KTDIPAVVER LEYDPNRTAN IALVLFKDGE RRYIIAPKGL SVGQEVLSSE
     TVPVKPGNCM PLRNIPLGTT VHCVELKPGK GAQLARSAGT SAQLVAREGA HATLRLRSGE
     MRKVLADCRA VIGEVSNSEH NLASLGKAGA TRWRGVRPTV RGVVMNPVDH PHGGGEGRTS
     GGRHPVSPWG MPTKGYKTRK NKRTDNMIVR RRKQK
//
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