ID H8I4R1_METCZ Unreviewed; 302 AA.
AC H8I4R1;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=Formylmethanofuran--tetrahydromethanopterin formyltransferase {ECO:0000256|HAMAP-Rule:MF_00579};
DE Short=Ftr {ECO:0000256|HAMAP-Rule:MF_00579};
DE EC=2.3.1.101 {ECO:0000256|HAMAP-Rule:MF_00579};
DE AltName: Full=H4MPT formyltransferase {ECO:0000256|HAMAP-Rule:MF_00579};
GN Name=ftr {ECO:0000256|HAMAP-Rule:MF_00579,
GN ECO:0000313|EMBL:AFD00656.1};
GN OrderedLocusNames=Mtc_1916 {ECO:0000313|EMBL:AFD00656.1};
OS Methanocella conradii (strain DSM 24694 / JCM 17849 / CGMCC 1.5162 /
OS HZ254).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanocellales; Methanocellaceae; Methanocella.
OX NCBI_TaxID=1041930 {ECO:0000313|EMBL:AFD00656.1, ECO:0000313|Proteomes:UP000005233};
RN [1] {ECO:0000313|EMBL:AFD00656.1, ECO:0000313|Proteomes:UP000005233}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 24694 / JCM 17849 / CGMCC 1.5162 / HZ254
RC {ECO:0000313|Proteomes:UP000005233};
RX PubMed=22493204; DOI=10.1128/JB.00207-12;
RA Lu Z., Lu Y.;
RT "Complete genome sequence of a thermophilic methanogen, Methanocella
RT conradii HZ254, isolated from Chinese rice field soil.";
RL J. Bacteriol. 194:2398-2399(2012).
CC -!- FUNCTION: Catalyzes the reversible transfer of a formyl group from
CC formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to
CC produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and
CC methanofuran (MFR). {ECO:0000256|HAMAP-Rule:MF_00579}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran
CC = methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin;
CC Xref=Rhea:RHEA:18061, ChEBI:CHEBI:15378, ChEBI:CHEBI:57727,
CC ChEBI:CHEBI:58018, ChEBI:CHEBI:58103, ChEBI:CHEBI:58151;
CC EC=2.3.1.101; Evidence={ECO:0000256|HAMAP-Rule:MF_00579};
CC -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); 5,10-
CC methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 2/3.
CC {ECO:0000256|HAMAP-Rule:MF_00579}.
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|HAMAP-Rule:MF_00579}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00579}.
CC -!- SIMILARITY: Belongs to the FTR family. {ECO:0000256|ARBA:ARBA00006770,
CC ECO:0000256|HAMAP-Rule:MF_00579}.
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DR EMBL; CP003243; AFD00656.1; -; Genomic_DNA.
DR AlphaFoldDB; H8I4R1; -.
DR STRING; 1041930.Mtc_1916; -.
DR KEGG; mez:Mtc_1916; -.
DR eggNOG; arCOG02695; Archaea.
DR HOGENOM; CLU_081314_0_0_2; -.
DR OMA; VIMCPAE; -.
DR OrthoDB; 81373at2157; -.
DR UniPathway; UPA00640; UER00693.
DR Proteomes; UP000005233; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030270; F:formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.70.520; -; 2.
DR HAMAP; MF_00579; FTR; 1.
DR InterPro; IPR014053; ForMFR_H4MPT_ForTrfase.
DR InterPro; IPR002770; ForMFR_H4MPT_ForTrfase_C.
DR InterPro; IPR023447; ForMFR_H4MPT_ForTrfase_fd-like.
DR InterPro; IPR022667; ForMFR_H4MPT_ForTrfase_N.
DR NCBIfam; TIGR03119; one_C_fhcD; 1.
DR Pfam; PF01913; FTR; 1.
DR Pfam; PF02741; FTR_C; 1.
DR PIRSF; PIRSF006414; Ftr_formyl_trnsf; 1.
DR SUPFAM; SSF55112; Formylmethanofuran:tetrahydromethanopterin formyltransferase; 2.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|HAMAP-Rule:MF_00579,
KW ECO:0000313|EMBL:AFD00656.1}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00579};
KW Methanogenesis {ECO:0000256|HAMAP-Rule:MF_00579};
KW One-carbon metabolism {ECO:0000256|HAMAP-Rule:MF_00579};
KW Reference proteome {ECO:0000313|Proteomes:UP000005233};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW Rule:MF_00579}.
FT DOMAIN 1..149
FT /note="Formylmethanofuran: tetrahydromethanopterin
FT formyltransferase Ftr N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01913"
FT DOMAIN 152..300
FT /note="Formylmethanofuran: tetrahydromethanopterin
FT formyltransferase Ftr C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02741"
SQ SEQUENCE 302 AA; 32482 MW; 61E356B97079926F CRC64;
MKYNNVEIDD TYAEAFPAQV SRVLITAVTE YYAKVAAIEA TGFGTSVIGC PAEAGIDCFV
PADKTPDGRP GYVIMICHPN KDKLKEQLIE RIGECVLTAP TTAVFNWLPF ERLPDKTQEK
RIDVKLHFFG DKFEYQTKVG DRNVWAIPIM GGEFICEEEY GYKKGVAGGN FFVMGETQGS
ALMGAQAAVD AIAQIEGCIT PFPGGIVSSG SKVGSKYKFM KASTNEKMAP TLKSKVPDTQ
LPPNVNAAYE IVIDGLDEAT VGKAMAAGIK AACHVPGVVK ISAGNYGGKL GPYKFELAKL
LQ
//