ID H8I4S0_METCZ Unreviewed; 461 AA.
AC H8I4S0;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Zn-dependent protease {ECO:0000313|EMBL:AFD00665.1};
GN OrderedLocusNames=Mtc_1925 {ECO:0000313|EMBL:AFD00665.1};
OS Methanocella conradii (strain DSM 24694 / JCM 17849 / CGMCC 1.5162 /
OS HZ254).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanocellales; Methanocellaceae; Methanocella.
OX NCBI_TaxID=1041930 {ECO:0000313|EMBL:AFD00665.1, ECO:0000313|Proteomes:UP000005233};
RN [1] {ECO:0000313|EMBL:AFD00665.1, ECO:0000313|Proteomes:UP000005233}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 24694 / JCM 17849 / CGMCC 1.5162 / HZ254
RC {ECO:0000313|Proteomes:UP000005233};
RX PubMed=22493204; DOI=10.1128/JB.00207-12;
RA Lu Z., Lu Y.;
RT "Complete genome sequence of a thermophilic methanogen, Methanocella
RT conradii HZ254, isolated from Chinese rice field soil.";
RL J. Bacteriol. 194:2398-2399(2012).
CC -!- SIMILARITY: Belongs to the peptidase U62 family.
CC {ECO:0000256|ARBA:ARBA00005836}.
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DR EMBL; CP003243; AFD00665.1; -; Genomic_DNA.
DR AlphaFoldDB; H8I4S0; -.
DR STRING; 1041930.Mtc_1925; -.
DR KEGG; mez:Mtc_1925; -.
DR eggNOG; arCOG00321; Archaea.
DR HOGENOM; CLU_026425_1_2_2; -.
DR Proteomes; UP000005233; Chromosome.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.2290.10; PmbA/TldD superfamily; 1.
DR InterPro; IPR045569; Metalloprtase-TldD/E_C.
DR InterPro; IPR045570; Metalloprtase-TldD/E_cen_dom.
DR InterPro; IPR002510; Metalloprtase-TldD/E_N.
DR InterPro; IPR025502; TldD.
DR InterPro; IPR035068; TldD/PmbA_N.
DR InterPro; IPR036059; TldD/PmbA_sf.
DR PANTHER; PTHR30624:SF0; METALLOPROTEASE SLR0863; 1.
DR PANTHER; PTHR30624; UNCHARACTERIZED PROTEIN TLDD AND PMBA; 1.
DR Pfam; PF01523; PmbA_TldD_1st; 1.
DR Pfam; PF19290; PmbA_TldD_2nd; 1.
DR Pfam; PF19289; PmbA_TldD_3rd; 1.
DR PIRSF; PIRSF004919; TldD; 1.
DR SUPFAM; SSF111283; Putative modulator of DNA gyrase, PmbA/TldD; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:AFD00665.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005233}.
FT DOMAIN 21..84
FT /note="Metalloprotease TldD/E N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01523"
FT DOMAIN 114..221
FT /note="Metalloprotease TldD/E central"
FT /evidence="ECO:0000259|Pfam:PF19290"
FT DOMAIN 228..460
FT /note="Metalloprotease TldD/E C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19289"
SQ SEQUENCE 461 AA; 49884 MW; 5D6E34A0AAE9C9BB CRC64;
MVIILILALE KALDSRADYF DIRLLEVTTT NLEMKNNEVT RAVAGRESGA CVRVLYRGAW
GFASTPDVRE PALKEAADKA ARMAKGVSEK VKEKSSLAPV RPSEGTADIP MKKSFLDMGI
ESKLGLLRST YDAVKDYDFI ASMTAAYKDD YTIEEFMSSE GSHIVTKTPR VFWSLELVGR
KDGDIQSVRR RIGNSMGFEA FDGDRHVAVA RDCAASLVAL LAGKSPPSGI MPVIVDHGLC
GVFAHEAVGH ASEGDLVATG NSCFEGLLGE QIGSELVTIK DDATIPGLFG SYIYDDEGVK
TRPKTLIEDG RLNGFILNRE TAARLGMEPN GGARAESYHH RPIVRMSNTY IDRGDATFKE
MIEDIKLGVY AKDSRGGQVN TSQGFFQFNA QEAYLIENGE ITKPLRDVSL SGKTLDILKL
IDMVGNDLVL GHPGICGKGQ SVPVGDGGPH VRISKCVVGG R
//
