ID   H8I6M6_METCZ            Unreviewed;       456 AA.
AC   H8I6M6;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   16-MAY-2012, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   RecName: Full=Nitrogenase iron-molybdenum cofactor biosynthesis protein NifE {ECO:0000256|ARBA:ARBA00013280};
GN   Name=nifE {ECO:0000313|EMBL:AFC98918.1};
GN   OrderedLocusNames=Mtc_0147 {ECO:0000313|EMBL:AFC98918.1};
OS   Methanocella conradii (strain DSM 24694 / JCM 17849 / CGMCC 1.5162 /
OS   HZ254).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanocellales; Methanocellaceae; Methanocella.
OX   NCBI_TaxID=1041930 {ECO:0000313|EMBL:AFC98918.1, ECO:0000313|Proteomes:UP000005233};
RN   [1] {ECO:0000313|EMBL:AFC98918.1, ECO:0000313|Proteomes:UP000005233}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 24694 / JCM 17849 / CGMCC 1.5162 / HZ254
RC   {ECO:0000313|Proteomes:UP000005233};
RX   PubMed=22493204; DOI=10.1128/JB.00207-12;
RA   Lu Z., Lu Y.;
RT   "Complete genome sequence of a thermophilic methanogen, Methanocella
RT   conradii HZ254, isolated from Chinese rice field soil.";
RL   J. Bacteriol. 194:2398-2399(2012).
CC   -!- FUNCTION: This protein may play a role in the biosynthesis of the
CC       prosthetic group of nitrogenase (FeMo cofactor).
CC       {ECO:0000256|ARBA:ARBA00003171}.
CC   -!- PATHWAY: Cofactor biosynthesis; Fe-Mo cofactor biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00005155}.
CC   -!- SIMILARITY: Belongs to the NifD/NifK/NifE/NifN family.
CC       {ECO:0000256|ARBA:ARBA00011002, ECO:0000256|RuleBase:RU004021}.
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DR   EMBL; CP003243; AFC98918.1; -; Genomic_DNA.
DR   AlphaFoldDB; H8I6M6; -.
DR   SMR; H8I6M6; -.
DR   STRING; 1041930.Mtc_0147; -.
DR   KEGG; mez:Mtc_0147; -.
DR   eggNOG; arCOG00598; Archaea.
DR   HOGENOM; CLU_025876_1_1_2; -.
DR   UniPathway; UPA00782; -.
DR   Proteomes; UP000005233; Chromosome.
DR   GO; GO:0016163; F:nitrogenase activity; IEA:InterPro.
DR   GO; GO:0009399; P:nitrogen fixation; IEA:UniProtKB-KW.
DR   GO; GO:0065003; P:protein-containing complex assembly; IEA:InterPro.
DR   Gene3D; 3.40.50.12380; Nitrogenase MoFe cofactor biosynthesis protein NifE, C-terminal; 1.
DR   Gene3D; 3.40.50.1980; Nitrogenase molybdenum iron protein domain; 1.
DR   InterPro; IPR000510; Nase/OxRdtase_comp1.
DR   InterPro; IPR000318; Nase_comp1_CS.
DR   InterPro; IPR005973; NifE.
DR   NCBIfam; TIGR01283; nifE; 1.
DR   PANTHER; PTHR42956; NITROGENASE IRON-MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN NIFE; 1.
DR   PANTHER; PTHR42956:SF1; NITROGENASE IRON-MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN NIFE; 1.
DR   Pfam; PF00148; Oxidored_nitro; 1.
DR   SUPFAM; SSF53807; Helical backbone' metal receptor; 1.
DR   PROSITE; PS00699; NITROGENASE_1_1; 1.
DR   PROSITE; PS00090; NITROGENASE_1_2; 1.
PE   3: Inferred from homology;
KW   Nitrogen fixation {ECO:0000256|ARBA:ARBA00023231,
KW   ECO:0000256|RuleBase:RU004021};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005233}.
FT   DOMAIN          47..441
FT                   /note="Nitrogenase/oxidoreductase component 1"
FT                   /evidence="ECO:0000259|Pfam:PF00148"
SQ   SEQUENCE   456 AA;  49880 MW;  67DC11080F3B63EA CRC64;
     MDAYCSQPVQ EALIDERQSS IVTKGKSKGH ISCTSDSIAG AVSQRACVYC GARVVLNPVT
     DAAHLVHGPI GCAAYTWDIR GSLSSGPEMY RNSFSTDLGE RDVIFGGERK LAACIDEIVA
     MHRPPAIFVY STCVIGVIGD DIGSVCREAS QRHGIDVIPV ESTGFRSGNK IIGYRAAADA
     LLKLIQPGEE AVKPTRKVNF LGEYNLGGEK WVVERYMRDI GVEVNVAFTG DSTVARLKQA
     PRACLNLVQC TGSMHYVARR MEEAFGIPYI DVNFFGADNT AESLRKIAEF YGEDAKNRAE
     ALIGREMARI GPSLRKYREK LAGKRAAIYV GGAFKASAII RQMKELGMEV VLTGTQTGKK
     EEYEKLDGML SDGAVIIDDA NPAEIEMFLR EKKVDVMVGG VKERFLAYKL GVGFVDHNHD
     RKECLAGFDG AVNFAREIYR TACSPVWKHV KKGVKP
//