ID   H8I8V0_METCZ            Unreviewed;       294 AA.
AC   H8I8V0;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   16-MAY-2012, sequence version 1.
DT   27-MAR-2024, entry version 40.
DE   SubName: Full=Methionine synthase (B12-independent) {ECO:0000313|EMBL:AFD00421.1};
DE            EC=2.1.1.14 {ECO:0000313|EMBL:AFD00421.1};
GN   Name=metE {ECO:0000313|EMBL:AFD00421.1};
GN   OrderedLocusNames=Mtc_1673 {ECO:0000313|EMBL:AFD00421.1};
OS   Methanocella conradii (strain DSM 24694 / JCM 17849 / CGMCC 1.5162 /
OS   HZ254).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanocellales; Methanocellaceae; Methanocella.
OX   NCBI_TaxID=1041930 {ECO:0000313|EMBL:AFD00421.1, ECO:0000313|Proteomes:UP000005233};
RN   [1] {ECO:0000313|EMBL:AFD00421.1, ECO:0000313|Proteomes:UP000005233}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 24694 / JCM 17849 / CGMCC 1.5162 / HZ254
RC   {ECO:0000313|Proteomes:UP000005233};
RX   PubMed=22493204; DOI=10.1128/JB.00207-12;
RA   Lu Z., Lu Y.;
RT   "Complete genome sequence of a thermophilic methanogen, Methanocella
RT   conradii HZ254, isolated from Chinese rice field soil.";
RL   J. Bacteriol. 194:2398-2399(2012).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
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DR   EMBL; CP003243; AFD00421.1; -; Genomic_DNA.
DR   RefSeq; WP_014406252.1; NC_017034.1.
DR   AlphaFoldDB; H8I8V0; -.
DR   STRING; 1041930.Mtc_1673; -.
DR   GeneID; 11971813; -.
DR   KEGG; mez:Mtc_1673; -.
DR   eggNOG; arCOG01876; Archaea.
DR   HOGENOM; CLU_040013_3_2_2; -.
DR   OrthoDB; 17656at2157; -.
DR   Proteomes; UP000005233; Chromosome.
DR   GO; GO:0003871; F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd03311; CIMS_C_terminal_like; 1.
DR   Gene3D; 3.20.20.210; -; 1.
DR   InterPro; IPR002629; Met_Synth_C/arc.
DR   InterPro; IPR038071; UROD/MetE-like_sf.
DR   PANTHER; PTHR30519; 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR30519:SF0; 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE; 1.
DR   Pfam; PF01717; Meth_synt_2; 1.
DR   SUPFAM; SSF51726; UROD/MetE-like; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Methyltransferase {ECO:0000313|EMBL:AFD00421.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005233};
KW   Transferase {ECO:0000313|EMBL:AFD00421.1};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          7..291
FT                   /note="Cobalamin-independent methionine synthase MetE C-
FT                   terminal/archaeal"
FT                   /evidence="ECO:0000259|Pfam:PF01717"
SQ   SEQUENCE   294 AA;  32378 MW;  AD9161340564C708 CRC64;
     MMVTTVVGSY PTGVNVQNEE DVRKAIEIAI ADQERAGISI ISDGQVRADM VGIFALNMPG
     YRKEGNRYKI VDRIEIPDKP ATVSDYLYAK KLARQAKVKG IITGPTTMAK SSIVEKGSPY
     KSNSDPELIY DIAYAQAAEA RALTQAGAEI IQIDEPFFSV DADLEVGIRA VNIISKGIDV
     PAMHVCGDIR PIFKKLLEAN VTILDHEFSS SKNLEAMDRD LIEAYGKIIG YGCVDTATDN
     VETAEQIERT IRMGIEKIGK KNMWIDPDCG LRMRTREAAY QKLANMVEAA RRIG
//