ID H8MFK6_CORCM Unreviewed; 1552 AA.
AC H8MFK6;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Polyketide synthase type I {ECO:0000313|EMBL:AFE09969.1};
GN Name=ppsE5 {ECO:0000313|EMBL:AFE09969.1};
GN OrderedLocusNames=COCOR_05736 {ECO:0000313|EMBL:AFE09969.1};
OS Corallococcus coralloides (strain ATCC 25202 / DSM 2259 / NBRC 100086 / M2)
OS (Myxococcus coralloides).
OC Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
OC Myxococcaceae; Corallococcus.
OX NCBI_TaxID=1144275 {ECO:0000313|EMBL:AFE09969.1, ECO:0000313|Proteomes:UP000007587};
RN [1] {ECO:0000313|EMBL:AFE09969.1, ECO:0000313|Proteomes:UP000007587}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25202 / DSM 2259 / NBRC 100086 / M2
RC {ECO:0000313|Proteomes:UP000007587};
RX PubMed=22582372; DOI=10.1128/JB.00397-12;
RA Huntley S., Zhang Y., Treuner-Lange A., Kneip S., Sensen C.W.,
RA Sogaard-Andersen L.;
RT "Complete Genome Sequence of the Fruiting Myxobacterium Corallococcus
RT coralloides DSM 2259.";
RL J. Bacteriol. 194:3012-3013(2012).
RN [2] {ECO:0000313|Proteomes:UP000007587}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25202 / DSM 2259 / NBRC 100086 / M2
RC {ECO:0000313|Proteomes:UP000007587};
RA Huntley S., Zhang Y., Treuner-Lange A., Sensen C.W., Sogaard-Andersen L.;
RT "Genome sequence of the fruiting myxobacterium Corallococcus coralloides
RT DSM 2259.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP003389; AFE09969.1; -; Genomic_DNA.
DR RefSeq; WP_014398524.1; NC_017030.1.
DR STRING; 1144275.COCOR_05736; -.
DR KEGG; ccx:COCOR_05736; -.
DR eggNOG; COG1028; Bacteria.
DR eggNOG; COG3321; Bacteria.
DR HOGENOM; CLU_000022_35_4_7; -.
DR InParanoid; H8MFK6; -.
DR OrthoDB; 7617297at2; -.
DR Proteomes; UP000007587; Chromosome.
DR GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008152; P:metabolic process; IEA:UniProt.
DR CDD; cd08953; KR_2_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007587};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 8..435
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1440..1515
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1410..1436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1513..1552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1525..1552
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1552 AA; 165820 MW; ADD2EEEC925C807E CRC64;
MSTDTPEVDG IAVIGLGGRL PGAKTISEFW KNLTGGVESI TFFTDEELIA EGADPAMVRA
PNYVKARGTL GDTDQFDAAF FGMNPREAAL MDPQHRVFLE CAWEAMESAG YSPERQPGRV
GVFGGMSMNT YLLSNLYSHL AHVASVESLQ ASIGNDKDSL TTEVAYRMDL KGPAVTVQSS
SSTSLTCIHY ACQSLLSFEC DMALAGGVSI HFPEKAGYLY HEGGTTAPDG HCHTFDAEAA
GFVAGHGAAV VALKRLSDAL KDGDTVYAVV RGSAVNNDGS QKVSYMAPAV AGQAEVIALA
QAVAGVDPDS IGYVEAHGTA TKVGDPIEVA ALTQAFRQGT DKKNFCALGS VKSNIGHLDS
AAGAVGFIKA ALTLHHKVIP PSLNFKTPNP ACDFPNSPFY VNTELRDFPR GETPRRAGVT
SLGMGGTNAH AILEEAPELP ATDKARLPAQ VVLLSARTEN SLEVATDRLA AHLRENPDVD
LADVAYTLQL GRKRFGKRRA VVARTTAELA SALAERTPGR VFSGSAENSG RPVMFMFSGQ
GSQYVDMGRE LYETEVLFRA QVDTCAEKLK PHLGLDLRTV LYPAAESREL ASERLKQTGL
TQPALFVIEY ALAKLWESWG VTPHAMVGHS IGEYVAACLA GVFTLDDALA LVAARGRLMQ
SLPAGSMLAV SLPEEHVTPM LPEGLSVAAV NSPATCVVAG PTPLIDAFVE TLKLQGLASS
RLHTSHAFHS AMMDPILDAF REAVRKVARK APTKPYLSNV TGTWVTAEQA TSPDYWAKHL
RGAVRFADGV AELLKESDAI LLEVGPGNTL VTLARQHPDK GAKHALINSL RHPKEQVADL
DHVLATLGRL WLEGVEADWD AFRGGEKRRR IALPTSPFER QRHWVDPRKD TAADGERAEW
ASADQKQPVA RWFYLPSWQR ALPSPQGTWS EKKATWWLLL PDDSNEGLGA RLALKLGEAG
QDVVRITPAA VTAKHDEHHW SLALGGEATV LEALTAQGRA PDHVLHLGTL GLGDAHGEAD
FESALGKGFL GLLSLAQALG RQPGTRPVSL VAVTNRMQAL GDEAPNPELA TVLGPVRVIP
QEYGHLSAKA VDVRLPASGS WQETALVEAL LSEAATPSKL ETVIAYRGGA RWVQHFEHVP
ADAPRTAQLP LRDGGVYLLI GGFGTLGFSH AKSLAKRAKA KLVLAGRTAL PERSQWDAHL
SAHGEDDAVS RRIRQVRELE ALGAEVHTVS VDAGNKVQVK EAVDAALTHF GALHGVVFAA
GDVGQALFRA IPDTRPEDVR DTFHGRVRGL YALEEAVRGR SLDFCVLSSS LAAVLGGLGL
ASYSAATSFM DAFATKQAQT SPVPWMSVGW DAWQYESRAG GAQSPFGALA ITASEGEDAF
EQLFQLGAVS HVAVSTSNLR ARARKWAQPA AAQEKAEAKQ EAGSSLGTTP RPALQNAYVP
PRDELEEKIA RLWQTTLGID QVGVHDNFFE LGGNSLVGVK LIARVREQFG VALPAVTLYE
GPTVGALAKL LKAASGSEDT EAAPEETEAL SRGERRRARR ANRRGDSASD EE
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