ID H8MK59_CORCM Unreviewed; 2866 AA.
AC H8MK59;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Linear gramicidin synthase subunit C {ECO:0000313|EMBL:AFE09203.1};
GN Name=lgrC {ECO:0000313|EMBL:AFE09203.1};
GN OrderedLocusNames=COCOR_00891 {ECO:0000313|EMBL:AFE09203.1};
OS Corallococcus coralloides (strain ATCC 25202 / DSM 2259 / NBRC 100086 / M2)
OS (Myxococcus coralloides).
OC Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
OC Myxococcaceae; Corallococcus.
OX NCBI_TaxID=1144275 {ECO:0000313|EMBL:AFE09203.1, ECO:0000313|Proteomes:UP000007587};
RN [1] {ECO:0000313|EMBL:AFE09203.1, ECO:0000313|Proteomes:UP000007587}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25202 / DSM 2259 / NBRC 100086 / M2
RC {ECO:0000313|Proteomes:UP000007587};
RX PubMed=22582372; DOI=10.1128/JB.00397-12;
RA Huntley S., Zhang Y., Treuner-Lange A., Kneip S., Sensen C.W.,
RA Sogaard-Andersen L.;
RT "Complete Genome Sequence of the Fruiting Myxobacterium Corallococcus
RT coralloides DSM 2259.";
RL J. Bacteriol. 194:3012-3013(2012).
RN [2] {ECO:0000313|Proteomes:UP000007587}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25202 / DSM 2259 / NBRC 100086 / M2
RC {ECO:0000313|Proteomes:UP000007587};
RA Huntley S., Zhang Y., Treuner-Lange A., Sensen C.W., Sogaard-Andersen L.;
RT "Genome sequence of the fruiting myxobacterium Corallococcus coralloides
RT DSM 2259.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: In the C-terminal section; belongs to the NRP synthetase
CC family. {ECO:0000256|ARBA:ARBA00029443}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP003389; AFE09203.1; -; Genomic_DNA.
DR RefSeq; WP_014393742.1; NC_017030.1.
DR STRING; 1144275.COCOR_00891; -.
DR KEGG; ccx:COCOR_00891; -.
DR eggNOG; COG1020; Bacteria.
DR eggNOG; COG3321; Bacteria.
DR HOGENOM; CLU_226601_0_0_7; -.
DR InParanoid; H8MK59; -.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000007587; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd12117; A_NRPS_Srf_like; 1.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR020802; PKS_thioesterase.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR001031; Thioesterase.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF00550; PP-binding; 3.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 3.
DR SMART; SM00824; PKS_TE; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007587};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 508..583
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1544..1619
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1636..2065
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2527..2602
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2866 AA; 310928 MW; 8754ADF9FE57549C CRC64;
MNSISVHPRL DIATLFEAHA RNTPDAVALH FEGGVLRYDT LNRRANRLAR RLQALGVGPD
QPVGILADRT PETVVGLLGI LKAGGAYLPL DPSHPPERLA AMMEDSGMRV LVGRREAVQE
LRFQGHVVEP PTPDEQEAVN VKGGAGPDSL AYVLYTSGST GRPKGVCIPH RGVARLVLDA
GFMGFRREDR VLQAASYAFD ASTLEVWGAL LNGATLCLVS RETLLSPPLL AAKLQRDAIS
AAVLSTSLFH QLAAAIPDAF GGLRVLMVGG DVLDPKWVGR VMARGKPQRL LNSYGPTECT
TSATAYELLV PPEPGVAIPI GRPLARLQLH VLDDGGKPLS VGEVGELYLG GEGLARGYLN
RPVLTAERFL PDPFSGVLGA RMYRTGDRAR WLQDGNLEFL GRVDHQVKIR GARVELAEIE
SVLRTHPRVG DAVVRVHEVS PGDKRLVAYV SPSGVEDAEL RAYLGSKLPD FMLPHAVMAL
EHMPLNSSGK VDPSRLPAPR FGSGEGETPR TQLEQEIARV WSEVLGTQQA GTQDRFMESG
GDSLLAIRFI DRLEQAVSVR LPVRTLFDSP NIAELARWVE AARGMGRGLD VPPIVPVDRT
RPLPLSDSQR QLWLMEQLAP RSAVYNEPFT LYLPGDLQPD ALERAFRSLI SRHEVLRTTF
GSTQDGPFQR VHPDMPFHLR RVDLHAVPGS LRSAKALQVA TQEAREPFDL EHGPLLRATW
MRLSKAESRL ALVMHHLIVD GFTMAAFLQE LHRFYLAEAP SLPPLPLQYG DAAVWQQGAR
YQEAIAPHLD WWKQTLAGAP HLELPTQHLR PQVPSFRGAR HVVRIPGDLL ESVKALGRGE
GASLFMTMLS VFGALLHRYS GAEDLIVGGA FSGRNREESQ AISGHFVNLL PLRLRFSEGQ
TIRGLLAQVR RVCLDALEHQ DAPLVRIVEA VNPARIPGAN PLFQVSCTME PRIAVPASDW
RVEPHDVDTG TSKLDLSIEL DERPDGMSVR WEYALDVFEP WMIHQLGQHF VTLLREAAQD
PEQRVAALPL LSEAEQSQVL AWAHGPVKDV SHADCLHHPF EAQVERTPDA PALFFQGRSM
SYRTLDAGAN RLAHHLISQG VQPGDFVGVC VQRSFELIIT LLGTLKAGAA YVPLDPAYPR
ARLEFTARDA GLRLILAQET TLALMDGAGV PVVALEQVRG GPEGTPRVHV TGDDLAYVIY
TSGSTGQPKG VCIRHRSAVH LTETVAWDFG FAPGQRVAQC ARYGFDFSVA EIFPTLSSGA
TLYLMGQEDL AAGEELADFL ETHRIHTAMF TPSALASMPW RALPDLKTLA LGGEELPARL
VDTWAPGRRF IQVYGPTEAT VFTTAAECVA GEGPYSIGTP LSGYEVYLLD ATLTPVPTGV
RGALYIGGKG LAHGYLNRPE LDAERFIPHP FSAEPGARLY KSGDIASHRP DGGIDFHGRS
DRQLKLRGFR IELGEIEAAL RKHPDVRDAV VEPRMLAGER HLVGYVIPRD AAVTPEFKES
LGETLPPHMV PREWVLLEAF PMGPTGKLDR HALPLPSVKA PSAPASTERE KALERIWCRI
LGVERVGRQE GFFDAGGNSL LLTRVQSALA SELDIRVSMA TLFQFPTIEA LARHLDADST
VQPVTPEPAR SPVRSPDPIA IIGTAGRFPG APSVEALWTL LVEGREGLSR FSRETLLAAG
EDPQLLEDPS YVRASGLLED VESFDAAFFG YSPLDARLMD PQLRMFLECA WEALEAAGYD
PKRLPGKAGL FAGSGVPRYW LDQVMPRFRS LSVASEAYRS ILGNPWQFLA TATAYQLGLH
GPALTVQTAC STSLVAVHLA CQSLRAGESD VALAGGISLF ASGPSGYLHE AGGITSPDGH
CRPFDAKGQG TVPSSGVGIV VLKRLEDALR DGDCIHAVIR GSAINNDGDA KVGFTAPSVE
GQRDVITRAH ADAGVAARDI TYVEAHGTAT PLGDPLEVQA LRLAFGAREE SEPAVVLGAL
KSNVGHLDSA AGVAGLIKTT LALEHRFLPG TVHFERPHPE AGLEHSPFVV SREGRPWSLP
EGFPRLAGVS SFGIGGTNAH VVLEEARPEP AVAVSPAVEV LVLSARSGEA LSAASRRLAD
HLERHPGQSL ADVAYTLQEG RTAFGYRRAI ACETPEEAIA KLRRDGPVQP AASPLPEVCF
LFPGTGTQEA GMGAAWYRRA PAYREAFDAC AALFGPELER ELRAALLTDE RGAQAEEALR
APSLGMAAIF TTEYALSRLL GAWGLHPTSL LGHSLGEYAA ACLSGVLSLE QAVALVALRG
RLCDALPPSG MLAVPLSEGV LTQELPSGLS LAAVNGPGQC VVSGALEALE DFAARLREQG
VRTKRLPNAS GFHSALVEPA MQPLTDLARS MRPKSPAVPL LSNVTGTWLT ADDAHDRTYW
ARHLRHTVRF SQGLELLLED RERIFVEVGP GQTLSTLTLL NPRVGRERLV LPTGRRHPPE
SDEQVLLHAV GQLWSAGLPV DWSAVRGGGP RRRVVLPTYP FERKRYSLAE KTPRLPRPEV
TTAPRPLSRE EVRASMEALW KELLGVDTLT PDSHFFELGG TSLLVVQLNR ELKTRLSVSL
SLHAVLEHPT LGEWVRAVQD ELERTGRPLT TAAPLRVELQ KGRHGRAPLF LVQPIGGTVY
TYLPLAKQLG ADTPVHAFRA SGLEPGEVLY RDVPAMARAY VDELLAFQSQ GPFWLGGHSS
GGVIAYEMAA ELLKRGHSVA GVIQIDTVTV DDSRRLNIRS VGDVLQLIDA FQEISPRAAE
GLRTAMELDT RLRDVVLATN EAIAAYAPGR HAVPLVYLRA TERDAVLDSR AAAWWTALTT
ASFQIHDVQG NHFTIMEAPH VVDLARLIQE QLTSGREGER DDLDAG
//
