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Database: UniProt
Entry: H8MSX6_CORCM
LinkDB: H8MSX6_CORCM
Original site: H8MSX6_CORCM 
ID   H8MSX6_CORCM            Unreviewed;       837 AA.
AC   H8MSX6;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   16-MAY-2012, sequence version 1.
DT   24-JAN-2024, entry version 46.
DE   RecName: Full=homoserine dehydrogenase {ECO:0000256|ARBA:ARBA00013213};
DE            EC=1.1.1.3 {ECO:0000256|ARBA:ARBA00013213};
GN   Name=thrA1 {ECO:0000313|EMBL:AFE10483.1};
GN   OrderedLocusNames=COCOR_06423 {ECO:0000313|EMBL:AFE10483.1};
OS   Corallococcus coralloides (strain ATCC 25202 / DSM 2259 / NBRC 100086 / M2)
OS   (Myxococcus coralloides).
OC   Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
OC   Myxococcaceae; Corallococcus.
OX   NCBI_TaxID=1144275 {ECO:0000313|EMBL:AFE10483.1, ECO:0000313|Proteomes:UP000007587};
RN   [1] {ECO:0000313|EMBL:AFE10483.1, ECO:0000313|Proteomes:UP000007587}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25202 / DSM 2259 / NBRC 100086 / M2
RC   {ECO:0000313|Proteomes:UP000007587};
RX   PubMed=22582372; DOI=10.1128/JB.00397-12;
RA   Huntley S., Zhang Y., Treuner-Lange A., Kneip S., Sensen C.W.,
RA   Sogaard-Andersen L.;
RT   "Complete Genome Sequence of the Fruiting Myxobacterium Corallococcus
RT   coralloides DSM 2259.";
RL   J. Bacteriol. 194:3012-3013(2012).
RN   [2] {ECO:0000313|Proteomes:UP000007587}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25202 / DSM 2259 / NBRC 100086 / M2
RC   {ECO:0000313|Proteomes:UP000007587};
RA   Huntley S., Zhang Y., Treuner-Lange A., Sensen C.W., Sogaard-Andersen L.;
RT   "Genome sequence of the fruiting myxobacterium Corallococcus coralloides
RT   DSM 2259.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-aspartate = 4-phospho-L-aspartate + ADP;
CC         Xref=Rhea:RHEA:23776, ChEBI:CHEBI:29991, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:57535, ChEBI:CHEBI:456216; EC=2.7.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00000709};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde +
CC         NADH; Xref=Rhea:RHEA:15757, ChEBI:CHEBI:15378, ChEBI:CHEBI:57476,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:537519; EC=1.1.1.3;
CC         Evidence={ECO:0000256|ARBA:ARBA00001406};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo
CC       pathway; L-homoserine from L-aspartate: step 1/3.
CC       {ECO:0000256|ARBA:ARBA00004986}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo
CC       pathway; L-homoserine from L-aspartate: step 3/3.
CC       {ECO:0000256|ARBA:ARBA00005062}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine
CC       from L-aspartate: step 1/5. {ECO:0000256|ARBA:ARBA00005139}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine
CC       from L-aspartate: step 3/5. {ECO:0000256|ARBA:ARBA00005056}.
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DR   EMBL; CP003389; AFE10483.1; -; Genomic_DNA.
DR   RefSeq; WP_014399211.1; NC_017030.1.
DR   AlphaFoldDB; H8MSX6; -.
DR   STRING; 1144275.COCOR_06423; -.
DR   KEGG; ccx:COCOR_06423; -.
DR   eggNOG; COG0460; Bacteria.
DR   eggNOG; COG0527; Bacteria.
DR   HOGENOM; CLU_009116_7_1_7; -.
DR   InParanoid; H8MSX6; -.
DR   OMA; LCYRTPE; -.
DR   OrthoDB; 9799110at2; -.
DR   UniPathway; UPA00050; UER00063.
DR   UniPathway; UPA00051; UER00465.
DR   Proteomes; UP000007587; Chromosome.
DR   GO; GO:0004072; F:aspartate kinase activity; IEA:InterPro.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd04892; ACT_AK-like_2; 1.
DR   Gene3D; 3.40.1160.10; Acetylglutamate kinase-like; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.30.2130.10; VC0802-like; 1.
DR   InterPro; IPR036393; AceGlu_kinase-like_sf.
DR   InterPro; IPR045865; ACT-like_dom_sf.
DR   InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR011147; Bifunc_aspartokin/hSer_DH.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43070; -; 1.
DR   PANTHER; PTHR43070:SF3; HOMOSERINE DEHYDROGENASE; 1.
DR   Pfam; PF00696; AA_kinase; 1.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   SUPFAM; SSF55021; ACT-like; 1.
DR   SUPFAM; SSF53633; Carbamate kinase-like; 1.
DR   SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW   Kinase {ECO:0000313|EMBL:AFE10483.1};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007587};
KW   Transferase {ECO:0000313|EMBL:AFE10483.1}.
FT   DOMAIN          114..294
FT                   /note="Aspartate/glutamate/uridylate kinase"
FT                   /evidence="ECO:0000259|Pfam:PF00696"
FT   DOMAIN          483..619
FT                   /note="Aspartate/homoserine dehydrogenase NAD-binding"
FT                   /evidence="ECO:0000259|Pfam:PF03447"
FT   DOMAIN          627..828
FT                   /note="Homoserine dehydrogenase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00742"
SQ   SEQUENCE   837 AA;  89307 MW;  54C9B8B7A403E62B CRC64;
     MTAPVSITRY APFLLDTAQG LASVATHLSR RDAGSTRAAI VSSPPWLAAG LESALSTALK
     GNSTLARQEL DGLLARGLLM LEEAERRLGA PPGSTSVEAD GSRTLASLLE PARRALDGAS
     LVRERRPALE DVVRGTGERL TAALLAKLLG ARGVPSLEVD AADWTVTEGE PGQARVNREH
     TRARVATLRP SWEGRLTLHA GGRGTAVDGR STTLGVEGAD ETAAVLSVLL GTPLTLWTDV
     PGVMTADPLH VADARPVPHL SYTEALELVY LGLPTLHPRA LSTLRDADIP LRVRHLQQPD
     EPGTLIDVRG AGNGTVPTCV VSLEDLALLG LEGGTEEAAR PVGPRALQAL EAAGIDAWMA
     AQSSPGRSVA VVLRRAHAAR AEQVLRRELA PELERGALQP PQVRAPVTQV ALVAEAMGQG
     ANVAGRLFQP LGALGVNVRA IAQTASARSI SFIVDGAETA LTVRTVHAAF HFAHEEVSLL
     VLGHGVVGSQ LLEQLRMLQE TLAQGHGIQL NLVGLADSRR VLFSPEGIPL KQWRERIQSV
     PEGASPPVVR ALLEPLRRLP VPVLVDCTAA EGMQELYLEA FRSGIHVVAA NKKPLTQPLE
     VWERLRSTAH LNHRAYHYET TVGAGLPVIQ TLKDLVRTGD RVHGVEGSFS GTLGYLSQQL
     MDGVPLSKAV RTAREKGFTE PHPREDLAGT DAARKALILA REQGLDLSME DVEVEPFVPR
     EYLEEADVER FLTGLEKLDR TFTSRIEGLR AEGKVLRYLA RIDPAAKDGP VLRVGPVAVP
     KEHPATRLRG SEAFVAFSTE RYADYPLLVQ GAGAGGPVTA AGVLADILKI AQNLRGR
//
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