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Database: UniProt
Entry: H8WGV2_CAEBR
LinkDB: H8WGV2_CAEBR
Original site: H8WGV2_CAEBR 
ID   H8WGV2_CAEBR            Unreviewed;      2921 AA.
AC   H8WGV2;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   16-MAY-2012, sequence version 1.
DT   07-JUN-2017, entry version 33.
DE   SubName: Full=Protein CBR-ITR-1, isoform a {ECO:0000313|EMBL:CCG58646.1};
GN   Name=itr-1 {ECO:0000313|WormBase:CBG05938a};
GN   Synonyms=Cbr-itr-1 {ECO:0000313|EMBL:CCG58646.1};
GN   ORFNames=CBG05938 {ECO:0000313|WormBase:CBG05938a}, CBG_05938
GN   {ECO:0000313|EMBL:CCG58646.1};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6238 {ECO:0000313|EMBL:CCG58646.1, ECO:0000313|Proteomes:UP000008549};
RN   [1] {ECO:0000313|EMBL:CCG58646.1, ECO:0000313|Proteomes:UP000008549}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16 {ECO:0000313|EMBL:CCG58646.1,
RC   ECO:0000313|Proteomes:UP000008549};
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A.,
RA   D'Eustachio P., Fitch D.H., Fulton L.A., Fulton R.E.,
RA   Griffiths-Jones S., Harris T.W., Hillier L.W., Kamath R.,
RA   Kuwabara P.E., Mardis E.R., Marra M.A., Miner T.L., Minx P.,
RA   Mullikin J.C., Plumb R.W., Rogers J., Schein J.E., Sohrmann M.,
RA   Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K., Durbin R.,
RA   Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for
RT   comparative genomics.";
RL   PLoS Biol. 1:166-192(2003).
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DR   EMBL; HE600909; CCG58646.1; -; Genomic_DNA.
DR   STRING; 6238.CBG05938a; -.
DR   EnsemblMetazoa; CBG05938a; CBG05938a; WBGene00028294.
DR   WormBase; CBG05938a; CBP45597; WBGene00028294; Cbr-itr-1.
DR   eggNOG; KOG3533; Eukaryota.
DR   eggNOG; ENOG410XR97; LUCA.
DR   InParanoid; H8WGV2; -.
DR   OMA; DPDDHYQ; -.
DR   Proteomes; UP000008549; Chromosome IV.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt-bd.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008549};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2508   2527       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2533   2550       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2599   2625       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2646   2668       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2763   2785       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      199    253       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      326    386       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      393    459       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      503    564       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN     1872   1932       MIR. {ECO:0000259|PROSITE:PS50919}.
SQ   SEQUENCE   2921 AA;  333728 MW;  418CA50D404D483F CRC64;
     MNSSFGRVRK KVSIISIPEF VPDSHDNENV ATSGGIVGDK TSSSAGGGGT RIEFDFDDFE
     EQIMRKSSMN LPSRKLTIAS SIDHGNNGNL HIGDIISLYT ESSTNQEQRG FLSTLGLVDD
     RCIVELKDGR PESPPKKFRD CLFKVCPVNR YAAQKHLWTE QKRFQTGDSM FDDDLMNKLR
     VAAEKEREEN EAEFQKTLGN IIQYGSMVQL LHVKSNKYIT VQKNSPAKRE RNAMKVYLDR
     AGNEGSWFII EPAYKHYAIG DNVSAGNKIS LIPNAVSTTQ TGHVKSQLHL SGLNLLDHQT
     AAEVNCLNEP TEWQVFMFLL FDENQQNSVK SGDVVRLFHA DQQTFLTLDT IPKTNPPKDV
     VFLRMTNRPS AADATSSRAL WEVQVVQSNA YRGGTAKWNK TYRFKHLASD MYLTVEESQM
     KAKPAMNGRP PLLSTLSQKS KILERTQSPL ASMYSDGPNG GNDTSDASDG PTVSFLSPKK
     SDFPEDDIKL LFELDPSTFM KSNKEVPRRS YVRLLHHKTA SWVHATNANE KQNLHFSNKN
     EKGWVKVICE THRVDKETFA LLPVNPDEVR DLDFANDACK ALRNFINLIK IGSVISKESL
     NSTTQLLIDC ILFVTNSSDH LADPLKITDF SPSRDRQKLL REQEVLHQVF LLLKAPFQPR
     QGSTELGPLL GSPADLSDSR NEIFKTMFQL CYCLLKYSQV SYRKNQEFLA EKFGEIQEQI
     GFDLMAEDTM TAVLHNNPKL LEKYVKAPHV ERFVDLVRNN RQGKFLDYLA DLCVCRGEAN
     KKIQELICTS VLSDKHRDIF MDTKVINGEV EIGWDPNFRK LVDIAEGAKS NHDDVEHLDY
     YRHQLDLLSQ MCQEQQYLAI DPPVERGLMN ISQQLPAELV LQCMSDTRLP YDLRGSFTRL
     MLHLHVVRGS PMSAIRHARL WRSIPESVNV STYESVSVEA YSDGSRMRIG ASIAHKVLAT
     VETYLMGLRD QPTDERHSVN SSKLTYEIVN LAKSLAQFNF YSFNELLQLT KNLLAIINEG
     PVPEQVPSHQ AMVNVIRNMS KSMLRGGNNK ENSKDLAKTP SMSTDDAGRS KEGRALIVKT
     KLIVAEILQF VMDVRRDYRI TMALSWFKNE FPCDEDGSLM HSASINEKMA SELYDAIYHS
     SGHELHLDGK DGQLLLAILL QMTMSDYPPL TSIALKVLFR HFTQYQELLE DLKQVQLLVS
     NDDVENYRQI DRDLFILKNL TEKSELWVHG DRNHSVETKE VEDKEKTTEY DLHMHQLNTP
     RAFESRDSMD AVIAVINEHY SNFKNESLQL LNRLLINDDR NDEAVALQEL SDKAPLIAYP
     LIRQMLVRLK RMCYRDGKPD TMNQQLLKNM RVYEVVLEFI SVPHDKKHDH EMMKLITLSH
     EFLRDFCKAN KENQSRLYKF ISYEKDAKEG MLRVETVEEV GTLVAIFRNN RELASNVPEE
     LIAHIVGLIE HNSRNPIFLE LLQALVCVYD KEIESGQEKV ANEICAASDE VRQLYVDNAS
     FEELEAMMKQ EKESRGRETE SRKPLKYHIE LVRLLAMCTR GKNGNTELKC ASQIPMDHIV
     RVVTSKHCLV EVKTVYLQLL LHCYIDTDAE MKDAYKTEYV DNILNNLLED IRSLRIDRLT
     DAETVALEHY ICHTVTEVLI KFFEAPYSAL QQAKVDVHHH KKTFSEVLLE LTSLERGKLK
     STRSSRNWYR VAECIKRLTK WAEEHISLPA TLVGPQMSAT ATVRQKWQNA ATSAKLIGLN
     KPVITLVVER LNRQNTLNPG HRLYGTSNSM TEHTSANVVT CYHMMIGEFK FYLHPLHAAE
     GSVLVEVLHT PELLFPEGSA LRDQCARGGV VAKLIQHCKT LMQNKQDNLC SRVLQTLCKM
     CDCTKQQLTQ QGRRFYNSSF EKGQQLRHLL LQRYFGHHNH HHPPLDRQQS KIGEVVEAVK
     EKKEETWSQE RDLYAIQCKL NDAGASDLVI DIIIMEPSRE IFLKAIHLAR ALLHEGNDKV
     QHSFYMRMKQ KDIHEPFFKV ILTRIQTAQN RLKSDMMSCS DSKPKPSLSA TVSRRSSTVL
     TPLIDAGDTG FNGTLFEVPQ QVRHPSISEM SQLSNDLTHS IPDLTPYQDE DKSADALPPE
     VALVEPILRV LQLLCENHNS LLQNFLRKQS DRTNHNLVSE TLSFLDTVCG STKGSLGVFG
     EIGEHNFSLI TQTLATLTEF CQGPCHENQN TMAMQENGLN IIISLVLNEI KPLADDHMEL
     ALEIKSQASK LLLAIMESRH DGENANRVLR NMANMSGGPK QLVHAIKQAY EMTRSNHHML
     KSVSRDLLRR AEDDSKSKSG PQITVNTITL PEINVDASGI VSIHTEKSIS SSLDDKFHED
     DSPSVDPREV GHNIYILAHQ LAIHDGELEI WLDGSDEKKD DLTREALNYY KERTAQIEIV
     RRDRTLERVV FPINEICSFL TKETKDYVYN NTERDNQGSK VTEFFDQWET MYHEMIWQRK
     LQDRKWLSWC AVRLPLWTRL SFQFAFIVNA LVALYYPFPE STSSSISFGN LYSWLAVISA
     FLLAHFLRHE KAYLSKTALL ILSSLCFLLV NSIGVNLTLY FFGMLQLVNK VIHVLAFVSN
     KGLEDRPLSE ILGCRNLHYL LVYLTVCIAG FVIHPMIYCA LLFDIIATEE TLQNVIASVT
     RNYQSIVWTG LLALILLYIF SILGFLFFRH DFYLEVDPVE PDSPASISGA LPTDTCPKEG
     CPGLERTKDN DDDDKKVKSC ETLWMCILQT MYLGLRNGGG IGDVLRNPAP WEDMFVWRVA
     YDMTFFVVLI VIVLNLIFGV IIDTFGDLRA EKNEKEQILK NNCFICGLDR SRFDNRSVTF
     ESHREMEHNI WHYLYYIVML QIKDETEFTG PESYVAQCVK ERNLDWFPRM QALSLQDSEL
     DTDQSEMKQM KDQMMQMMAM MRENQSQWDE VRAFMEQLQS R
//
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