ID   H8XAL3_CANO9            Unreviewed;       698 AA.
AC   H8XAL3;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   16-MAY-2012, sequence version 1.
DT   24-JAN-2024, entry version 44.
DE   SubName: Full=Cdc45 DNA replication initiation factor {ECO:0000313|EMBL:CCG24863.1};
GN   ORFNames=CORT_0G01780 {ECO:0000313|EMBL:CCG24863.1};
OS   Candida orthopsilosis (strain 90-125) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=1136231 {ECO:0000313|EMBL:CCG24863.1, ECO:0000313|Proteomes:UP000005018};
RN   [1] {ECO:0000313|EMBL:CCG24863.1, ECO:0000313|Proteomes:UP000005018}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=90-125 {ECO:0000313|Proteomes:UP000005018};
RX   PubMed=22563396; DOI=10.1371/journal.pone.0035750;
RA   Riccombeni A., Vidanes G., Proux-Wera E., Wolfe K.H., Butler G.;
RT   "Sequence and analysis of the genome of the pathogenic yeast Candida
RT   orthopsilosis.";
RL   PLoS ONE 7:e35750-e35750(2012).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the CDC45 family.
CC       {ECO:0000256|ARBA:ARBA00010727}.
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DR   EMBL; HE681725; CCG24863.1; -; Genomic_DNA.
DR   RefSeq; XP_003870989.1; XM_003870940.1.
DR   AlphaFoldDB; H8XAL3; -.
DR   GeneID; 14542112; -.
DR   KEGG; cot:CORT_0G01780; -.
DR   eggNOG; KOG2475; Eukaryota.
DR   HOGENOM; CLU_005871_3_0_1; -.
DR   OrthoDB; 1407079at2759; -.
DR   Proteomes; UP000005018; Chromosome 7.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   InterPro; IPR003874; CDC45.
DR   PANTHER; PTHR10507; CDC45-RELATED PROTEIN; 1.
DR   PANTHER; PTHR10507:SF0; CELL DIVISION CONTROL PROTEIN 45 HOMOLOG; 1.
DR   Pfam; PF02724; CDC45; 1.
PE   3: Inferred from homology;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   Initiation factor {ECO:0000313|EMBL:CCG24863.1};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Protein biosynthesis {ECO:0000313|EMBL:CCG24863.1}.
FT   REGION          171..223
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        173..203
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   698 AA;  80122 MW;  75162DC383E04B02 CRC64;
     MYITPNQYFA TYRDLKRTSL SHSTCKLVIF VSCLDVDSLC AAKMFSLLLK KELIQYQLLP
     VVGYKDLKSH YDRLDDDVTN VVLIGCGAML DVENFLDVNP EELLDNSAEQ PEDDQDLNDV
     KKNQFRRKIY IIDGHRPWNL DNLFGSEIVV CLDDGYVDGT LLEEKKAYEG LILEDEEEES
     GSDSESDFSD DEELDEETDV DMPSESELVI NSQDPEDTVT RKRKLQEKYS RQLRKQKKQK
     KSVNEDKLQS YYNQGSTIST ANTITVYALL TAIGETNLES LWIAIIGTSS LDSHYPEIYD
     KLQPLLKEEV MRLNPEHENT KKKADQTILR VERDYHLFLL RHWTLYDSFF YSSHVNSKLN
     LWTDEGKKRL HKLFAKMGVS LAVAQQKWLY MDTKVKRQLP IIFRRYLPIY GLEGIVREGF
     IKTYGYTGSL SAMECVEALS ALLELDEKFI QESAKLNEED NKTLDNEDDK IRKRMERKES
     SWLSNFWSSW DALNVTKSLK TSANQTSPFT KLKGSELLFR GLEYAKQLQQ ITFRTGMSLL
     ERKMIKNLKL YRLCVLNDGA VPDLEIFINP LMLSKLGTWL IENLAELDFI NGNHSLKPLV
     VASLDVSSDT YLVIGLAPRY PRGMSNSEKA KLLQEQTNDK ITAESMTTHL NTFSVAFQQL
     SNTSGAKVRV DSFDSSIIEI RKDDLAPFLE KLTLSGLI
//