ID H8XBE7_CANO9 Unreviewed; 652 AA.
AC H8XBE7;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE SubName: Full=Sac7 GTPase activating protein (GAP) for RHO1 {ECO:0000313|EMBL:CCG25135.1};
GN ORFNames=CORT_0H00170 {ECO:0000313|EMBL:CCG25135.1};
OS Candida orthopsilosis (strain 90-125) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=1136231 {ECO:0000313|EMBL:CCG25135.1, ECO:0000313|Proteomes:UP000005018};
RN [1] {ECO:0000313|EMBL:CCG25135.1, ECO:0000313|Proteomes:UP000005018}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=90-125 {ECO:0000313|Proteomes:UP000005018};
RX PubMed=22563396; DOI=10.1371/journal.pone.0035750;
RA Riccombeni A., Vidanes G., Proux-Wera E., Wolfe K.H., Butler G.;
RT "Sequence and analysis of the genome of the pathogenic yeast Candida
RT orthopsilosis.";
RL PLoS ONE 7:e35750-e35750(2012).
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DR EMBL; HE681726; CCG25135.1; -; Genomic_DNA.
DR RefSeq; XP_003871260.1; XM_003871211.1.
DR AlphaFoldDB; H8XBE7; -.
DR GeneID; 14542354; -.
DR KEGG; cot:CORT_0H00170; -.
DR eggNOG; KOG2710; Eukaryota.
DR HOGENOM; CLU_016108_1_0_1; -.
DR OrthoDB; 25175at2759; -.
DR Proteomes; UP000005018; Chromosome 8.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15228; SPERMATHECAL PHYSIOLOGY VARIANT; 1.
DR PANTHER; PTHR15228:SF25; SPERMATHECAL PHYSIOLOGY VARIANT; 1.
DR Pfam; PF00620; RhoGAP; 2.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
FT DOMAIN 159..484
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 33..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 311..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 496..557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 611..652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..537
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 636..652
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 652 AA; 72548 MW; 0B70D184A143000D CRC64;
MSHSQSPNNR GSIFGWAKSL KRSNLLSNES VNEISDNDSI SKSPTKASYT SPHQQHSPLN
IPNANAHNTQ SSDSQNSFYQ QQSSHHNHGG NFFGTSPTGS SHHSDFLRPL LNHKSRSTNN
VSRVRSNSLN QSESSIRQHR DSFMQTNALV DENSKYFGVP LQQALDESSA KISILTGDQS
DGLQYGQIPI VVAKCGVYLK KNGLTVEGIF RVGGSSKRIK DLQVIFNTPP SFGKQLNWDG
YTVHDAASIL RRYLNALPEP LIPLNMYDDF REPLRNRRRI ISYMQYKAEN PSKSLKQASV
EDVSSTSQML TEANVEKFND NGVSDFRRRN DSNVSSHPTS SIQPPTEQSR HVEQQSQSQF
SSSSPQQPQQ LQQRQPTEEE IELKNKKKSK NYKKLTRDVH AAIDEYKHLV NDLPLASKQL
LFYVLDLLAM VRNHSKENLM SSRNLAAIFQ PSILSHPNHD LDPDEYALSQ LVVEFLIHYA
YKLLPTHTSK SVSINTNEDV VPTEPPQALQ SAVTSTSTTP LESATSLSKN DLSSKEPIVS
AQPAPPPFNR RHSKSLSSAG NHEDLVVGYQ HNVTGSIPFE SDVDYISDEN DIGSDVEESY
FNQSRLANAG SPMRINFDNE RPNAEPEVPK NGTSEEPVII VTTPSSGPTT AK
//
