ID H8XWG6_MACFA Unreviewed; 264 AA.
AC H8XWG6;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=Apolipoprotein A-IV {ECO:0000256|ARBA:ARBA00041197};
DE AltName: Full=Apolipoprotein A4 {ECO:0000256|ARBA:ARBA00042591};
DE Flags: Fragment;
GN Name=APOA4 {ECO:0000313|EMBL:AEH95750.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|EMBL:AEH95750.1};
RN [1] {ECO:0000313|EMBL:AEH95750.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22197807; DOI=10.1016/j.ympev.2011.12.008;
RA Prothmann A., Laube I., Dietz J., Roos C., Mengel K., Zischler H.,
RA Herlyn H.;
RT "Sexual size dimorphism predicts rates of sequence evolution of SPerm
RT Adhesion Molecule 1 (SPAM1, also PH-20) in monkeys, but not in hominoids
RT (apes including humans).";
RL Mol. Phylogenet. Evol. 63:52-63(2012).
CC -!- FUNCTION: May have a role in chylomicrons and VLDL secretion and
CC catabolism. Required for efficient activation of lipoprotein lipase by
CC ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL
CC and chylomicrons. {ECO:0000256|ARBA:ARBA00037735}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the apolipoprotein A1/A4/E family.
CC {ECO:0000256|ARBA:ARBA00008788}.
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DR EMBL; HM485445; AEH95750.1; -; Genomic_DNA.
DR AlphaFoldDB; H8XWG6; -.
DR GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR Gene3D; 6.10.250.2890; -; 1.
DR Gene3D; 1.20.120.20; Apolipoprotein; 1.
DR InterPro; IPR000074; ApoA_E.
DR PANTHER; PTHR18976; APOLIPOPROTEIN; 1.
DR PANTHER; PTHR18976:SF1; APOLIPOPROTEIN A-IV; 1.
DR Pfam; PF01442; Apolipoprotein; 1.
DR SUPFAM; SSF58113; Apolipoprotein A-I; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; HDL {ECO:0000256|ARBA:ARBA00022850};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Lipoprotein {ECO:0000313|EMBL:AEH95750.1};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT COILED 153..184
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AEH95750.1"
FT NON_TER 264
FT /evidence="ECO:0000313|EMBL:AEH95750.1"
SQ SEQUENCE 264 AA; 30684 MW; AFA88E231785B819 CRC64;
FATELHERLA KDSEKLKEEI RKELEEVRAR LLPHANEVSQ KIGENVRELQ QRLEPYTDQL
RAQVNTQTEQ LRRQLTPYAQ RMERVLRENA DSLQTSLRPH ADQLKAKIDQ NVEELKERLT
PYADEFKVKI DQTVEELRRS LAPYAQDAQE KLNHQLEGLA FQMKKNAEEL KARISASAEE
LRQRLAPLAE DMRGNLRGNT EGLQKSLAEL GGHLDRHVEE FRLRVEPYGE NFNKALVQQM
EQLRQKLGPH AGDVEGHLSF LEKD
//
