ID   H8Y222_9NEOB            Unreviewed;        75 AA.
AC   H8Y222;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   16-MAY-2012, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Antimicrobial peptide {ECO:0000313|EMBL:AEZ53014.1};
OS   Odorrana tiannanensis (Dawei frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Odorrana.
OX   NCBI_TaxID=448113 {ECO:0000313|EMBL:AEZ53014.1};
RN   [1] {ECO:0000313|EMBL:AEZ53014.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=21963433; DOI=10.1016/j.biochi.2011.09.017;
RA   He W., Feng F., Huang Y., Guo H., Zhang S., Li Z., Liu J., Wang Y., Yu H.;
RT   "Host defense peptides in skin secretions of Odorrana tiannanensis: Proof
RT   for other survival strategy of the frog than merely anti-microbial.";
RL   Biochimie 94:649-655(2012).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JF330007; AEZ53014.1; -; mRNA.
DR   AlphaFoldDB; H8Y222; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:UniProt.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:UniProt.
DR   InterPro; IPR012521; Antimicrobial_frog_2.
DR   InterPro; IPR004275; Frog_antimicrobial_propeptide.
DR   Pfam; PF08023; Antimicrobial_2; 1.
DR   Pfam; PF03032; FSAP_sig_propep; 1.
PE   2: Evidence at transcript level;
KW   Amphibian defense peptide {ECO:0000256|ARBA:ARBA00022446};
KW   Antimicrobial {ECO:0000256|ARBA:ARBA00022529};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..75
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003617174"
FT   DOMAIN          4..41
FT                   /note="Frog antimicrobial peptide propeptide"
FT                   /evidence="ECO:0000259|Pfam:PF03032"
FT   DOMAIN          43..75
FT                   /note="Frog antimicrobial peptide brevinin-2/esculentin
FT                   type"
FT                   /evidence="ECO:0000259|Pfam:PF08023"
SQ   SEQUENCE   75 AA;  8171 MW;  4CE4B884B8A946CE CRC64;
     MLPLKKSLLL LFFLGTISLS LCQEERDADE EEGEMIEEEV KRSLLGTVKD LLIGAGKSAA
     QSVLKGLSCK LSKDC
//