ID H9AY05_ECOLX Unreviewed; 917 AA.
AC H9AY05;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=IncX type IV secretion system protein VirB4 {ECO:0000313|EMBL:AFC60920.1};
GN Name=virB4 {ECO:0000313|EMBL:AFC60920.1};
GN ORFNames=ec14_32 {ECO:0000313|EMBL:AFC60920.1};
OS Escherichia coli.
OG Plasmid pEC14_35 {ECO:0000313|EMBL:AFC60920.1}.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=562 {ECO:0000313|EMBL:AFC60920.1};
RN [1] {ECO:0000313|EMBL:AFC60920.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EC14 {ECO:0000313|EMBL:AFC60920.1};
RC PLASMID=pEC14_35 {ECO:0000313|EMBL:AFC60920.1};
RX PubMed=22470007; DOI=10.1016/j.plasmid.2012.03.001;
RA Johnson T.J., Bielak E.M., Fortini D., Hansen L.H., Hasman H., Debroy C.,
RA Nolan L.K., Carattoli A.;
RT "Expansion of the IncX plasmid family for improved identification and
RT typing of novel plasmids in drug-resistant Enterobacteriaceae.";
RL Plasmid 68:43-50(2012).
CC -!- SIMILARITY: Belongs to the TrbE/VirB4 family.
CC {ECO:0000256|ARBA:ARBA00006512}.
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DR EMBL; JN935899; AFC60920.1; -; Genomic_DNA.
DR RefSeq; WP_015059078.1; NZ_VKYF01000047.1.
DR RefSeq; YP_006953691.1; NC_019083.1.
DR AlphaFoldDB; H9AY05; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR018145; CagE_TrbE_VirB_cntrl_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR043964; P-loop_TraG.
DR InterPro; IPR007792; T4SS_VirB3/TrbD/AvhB.
DR PANTHER; PTHR30121:SF6; TYPE IV SECRETION SYSTEM PROTEIN CAGE; 1.
DR PANTHER; PTHR30121; UNCHARACTERIZED PROTEIN YJGR-RELATED; 1.
DR Pfam; PF03135; CagE_TrbE_VirB; 1.
DR Pfam; PF19044; P-loop_TraG; 1.
DR Pfam; PF05101; VirB3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plasmid {ECO:0000313|EMBL:AFC60920.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..38
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 272..474
FT /note="CagE TrbE VirB component of type IV transporter
FT system central"
FT /evidence="ECO:0000259|Pfam:PF03135"
FT DOMAIN 689..816
FT /note="TraG P-loop"
FT /evidence="ECO:0000259|Pfam:PF19044"
SQ SEQUENCE 917 AA; 104923 MW; 469E1EFA84DDAFF5 CRC64;
MSTVFKGLTR PALIRGLGVP LYPFLGMCVI CVLLGVWIHE AMYALILPGW YAIKRVTKID
ERFFDLLYLR MQIKGNPLAN KRFNAVHYAG SSYDAVDISK VDNFMKLKDQ SSLEELIPYS
SHITENLIVT KNHDLIATWQ IDGAYFECVD DADLTLLTDQ LNTLIRSFDG KPVTFYDHRI
RGKKSVQPTF KSKIPFVNRV MNDYYSSLSE SEYFENKLYL SVCYKPFSAE DKVTHFLSRK
KGNKNIFEEP INDMNEICGR LSTYLSRFHS RRLGLYEENG VVYSDQLSLF QKLLSGRWQK
VRVTNSPFYT YLGGKDVFFG NDAGQITASD HARYFRCIEI KDYFRETDAG IFDALMYLPV
EYVQTSSFTP IDKQSAIKAL DDQIDKLEMT DDAAQSLLTD LKVALDMVSS GYISFGKSHQ
TLIVYADTPE RLVKDTNIVT TTLEDLGLIV TYSTMSLGAA YFAQLPGNYT LRPRLSPISS
LNFAEMESFH NFFTGKEKGN TWGNNLITLG GSGNDVYHLN YHMTTEHQNY FGKNPTLGHT
EILGTSNVGK TVVMMAKAFA AQQFGTPESF PPERKHKKLT TVWFDKDRAA EPGIRSMGGA
YYRVKEGEPT GWNPAALPPT KRNISFMKDL VRLICSLNSE PLDDYQNRLI SDAVERLMQR
SDRSYPISKL RPLILEPDDT ETRRHGLKAR LKPWTQGEEF GWVIDNPEDT FDVDNLDVFG
IDGTEFLDNK VLSSVASFYL IYRVTMLADG RRLLIYMDEF WQWINNEAFR DFVYNKLKTA
RKLDMVLVVA TQSPDELIKS PIAAAVREQC ATHIYLANPN AKRNEYVDEL QVRELYFDKI
KAIDPLSRQF LVVKNPQRKG ESNDFAAFAR LDLGKAAYYL PVLSASKPQL ELFDEIWKEG
MKPEEWLDIY LERANLI
//